ACTH 4-9 analog can retard spatial alternation learning in brain damaged and normal rats

Thirty adult male hooded rats (Long-Evans strain) were assigned randomly to one of three lesion groups (n = 10) and prepared with medial frontal, posterior parietal, or sham neocortical injuries. Following a recovery interval of 10-12 days, access to water was limited to 30 min per day and the rats were shaped to traverse a T-maze for a reward of sweetened water. After a pretraining criterion was attained, osmotic minipumps (Alzet 2002) were installed subcutaneously. The minipumps delivered chronically for the next 14 to 15 days either 0 or 1.2 micrograms of ACTH 4-9 dissolved in bacteriostatic saline per day while the rats were trained on a reinforced spatial alternation task. Analysis of the number of errors made to a criterion of at least 80% correct alternations in two consecutive training sessions, or a ceiling of 62 errors (attained by two rats with parietal lesions), revealed that learning was impaired in the rats with parietal injuries. Contrary to our hypothesis, animals receiving ACTH 4-9 committed more errors than their counterparts receiving only saline.     

Context effects in stroop-like word and picture processing

Presents a series of 6 experiments in which Stroop-like effects were generated by modally pure color-color, picture-picture, and word-word stimuli instead of the usual modally mixed color-word or picture-word stimuli. Naming, reading, and categorization tasks were applied. The Stroop inhibition was preserved with these stimuli but unexpectedly showed a semantic gradient only in the naming and not in the reading task. Word categorizing was slower and more interference prone than picture categorizing. These and other results can be captured by a model with two main assumptions: (a) semantic memory and the lexicon are separate, and (b) words have privileged access to the lexicon, whereas pictures and colors have privileged access to the semantic network. Such a model is developed and put to an initial test.     

Video-task assessment of learning and memory in macaques (Macaca mulatta): effects of stimulus movement on performance

Effects of stimulus movement on learning, transfer, matching, and short-term memory performance were assessed with 2 monkeys using a video-task paradigm in which the animals responded to computer-generated images by manipulating a joystick. Performance on tests of learning set, transfer index, matching to sample, and delayed matching to sample in the video-task paradigm was comparable to that obtained in previous investigations using the Wisconsin General Testing Apparatus. Additionally, learning, transfer, and matching were reliably and significantly better when the stimuli or discriminanda moved than when the stimuli were stationary. External manipulations such as stimulus movement may increase attention to the demands of a task, which in turn should increase the efficiency of learning. These findings have implications for the investigation of learning in other populations, as well as for the application of the video-task paradigm to comparative study.     

Attenuation of amphetamine-stereotypy by mesostriatal dopamine depletion enhances plasma corticosterone: implications for stereotypy as a coping response

The relationship between amphetamine-induced stereotyped behavior and a neuroendocrine index of arousal, plasma corticosterone (CCS), was investigated. 6-Hydroxydopamine lesions of the caudate-putamen, which produced dopamine depletions of 60%, blocked stereotypy and prolonged the elevation in corticosterone associated with d-amphetamine treatment (5 mg/kg). Similar dopamine depleting lesions of the nucleus accumbens, which attenuated the locomotor, but not the stereotypic, response to AMPH did not have this effect on CCS. This pattern of results supports the hypothesis that stereotypy has a coping function which may serve to alter arousal and further suggests important differences between the nigrostriatal and mesolimbic dopamine projections in modulating the responsiveness of the neuroendocrine system. These results have implications for understanding the function of behavioral stereotypies common to a number of psychopathological conditions, including schizophrenia and childhood autism.     

Effects of attentional focusing on pain perception

Two experiments were conducted to examine the hypothesized differential effectiveness of two attentional focusing strategies in pain perception. In the first experiment, subjects (72 male college students) rated their levels of pain after being exposed to either low- or high-intensity pressure stimulation for 75 s. Subjects were instructed to use either an external or internal focus of attention during the pain induction. Results revealed that external focusing was more effective for coping than internal focusing across both levels of stimulus intensity. The second experiment was a replication of the first, and featured bolstered internal focusing and stimulus intensity manipulations. Results showed that high-intensity stimulation produced higher pain ratings than did low-intensity stimulation for subjects in the internal focusing conditions, but not for those in the external focusing conditions. The findings support the power of distraction strategies for dealing with short-term pain with a rapid onset. Theoretical implications are discussed.The authors thank Darwyn E. Linder and Daniel M. Landers for their help in development of this research. The authors are also indebted to Sarah Colley, Jona Davis, Nanci Neuberger, and Rebecca Roberts for their assistance in data collection.     

Aversiveness of denatonium saccharide and quinine in grasshopper mice Onychomys leukogaster

The responses toward denatonium saccharide and quinine by three rodent species differ from those exhibited by humans. This study measured the relative aversiveness of these two compounds in grasshopper mice (Onychomys leucogaster) to determine if this species responded similarly to or differently from these other rodents. In a choice test, the mice clearly preferred quinine over denatonium saccharide at concentrations of 1/10,000 and 1/50,000, but only marginally preferred quinine at a concentration of 1/1000. When denatonium or quinine was paired with toxicosis, both suppressed drinking at concentrations from 1/10,000 to 1/50,000, but only denatonium suppressed drinking at 1/100,000. Neither compound suppressed drinking at 1 part in million. Grasshopper mice perceived denatonium saccharide as more aversive than quinine in both experiments. Such a response resembled the behavior of humans more than that of the other three rodents previously tested.     

Smoking, body weight, and their effects on smoking behavior: a comprehensive review of the literature

This article provides a comprehensive review of the research on smoking and body weight. The relationships between smoking and body weight are evaluated in 70 cross-sectional and longitudinal investigations. The mechanisms responsible for differences in body weight are discussed, the weight-related issues that promote smoking behavior are reviewed, methods for reducing postcessation weight gain are summarized, and future research directions are proposed. A proposed working research model for studying the relationship between smoking, energy balance, and weight gain is offered. It is concluded that smoking and body weight relationships are closely related and pose significant challenges for smoking researchers.     

Negative afterimages and the McCollough effect

Four experiments were conducted to test earlier claims about the relationship between the negative afterimage and the McCollough effect. The first claim (Hansel & Mahmud, 1978) is that long-lasting afterimages occur when induced by the same alternating-stimulus procedure as that used to induce the McCollough effect. The second claim (Murch & Hirsch, 1972) is that afterimages can themselves induce McCollough effects if they are induced and paired sequentially with grating patterns. In testing these claims, a reliable computer-controlled color-cancellation technique developed earlier was used to measure the apparent color of both afterimages and McCollough effects objectively. No support was found for the first claim following alternative presentation of two homogeneously colored regions for total periods of 5 min (Experiment 1) and 20 min (Experiment 2). The second claim was fully supported: After an induction period of 7.3 min, a McCollough effect occurred for a red-vertical pairing but not for a green-horizontal pairing (Experiment 3); but after an induction period of 20 min, McCollough effects occurred strongly for both pairings (Experiment 4). The theoretical implications of these outcomes are considered in the context of recent theories of color and pattern processing in the visual system.     

Development of perceived adolescent relationship scale

The purpose of the present study was to develop an easily administered scale to assess adolescents' perceptions of both their own social competence and social participation in relationships. Six items were used to generate two factors that accounted for about 68% of the variance.     

Instructional and probability manipulations of bias in multiletter matching

Ratcliff (1985) performed fits of his diffusion model to the results of multiletter-matching experiments conducted by Ratcliff and Hacker (1981) and Proctor, Rao, and Hurst (1984), in which bias to respond "same" or "different" was manipulated by instructions and probabilities, respectively. The fits showed that both bias manipulations affected settings of a goodness-of-match criterion, whereas instructions also affected sensitivity. Evaluations of the experimental procedures and of Ratcliff's model-fitting procedures were performed in the present study. Three experiments showed that instructions and probabilities had similar effects, regardless of whether the different pairs were blocked or randomized according to the number of mismatching positions. The most salient feature of the results--that "same" reaction times were traded off more than were "different" reaction times, with no corresponding asymmetry in the error rates--was evident in all situations. The evaluation of Ratcliff's model-fitting procedures indicated that the apparent influence of instructions on sensitivity likely is an artifact of unequal variance for the sets of same and different pairs. Moreover, the effects of bias can be explained in terms of settings of response criteria, rather than of the goodness-of-match criterion, as in Ratcliff's fits.