Theory of Mind in Patients with Epilepsy: a Systematic Review and Meta-analysis

The ability to understand our own thoughts, intentions, beliefs and emotions and those of others (Theory of Mind; ToM) is a high-order social cognitive skill that is vital for social interaction and which has been found to be impaired in patients with epilepsy. Studies examining ToM in patients with epilepsy, however, have yielded inconsistent findings. The main aim of this study is to determine whether the magnitude of ToM deficits varies as a function of the site of epilepsy focus and/or the type of ToM task used. Electronic databases searches included Psychinfo, Medline/PubMed and EMBASE. Studies were included if they examined a group of patients with epilepsy and a group of healthy controls, reported original research, were published in the English language in peer reviewed journals, and used one of five empirically validated measures of ToM: False Belief, Reading the Mind in the Eyes Task (RMET), Faux-pas, Strange Stories, Cartoon ToM vignettes. Twelve studies were identified, ten included adults and two included children with epilepsy. Findings revealed marked ToM deficits in adults with focal seizures emanating from core brain regions underpinning ToM: temporal and frontal lobes (frontal lobe epilepsy, FLE; temporal lobe epilepsy, TLE), but not in adults with focal seizures outside the temporal and frontal lobes (extra-TLE/FLE). ToM deficits were also observed in children with generalised seizures (idiopathic generalised epilepsy, IGE). ToM deficits were documented across ToM tasks. In conclusion, ToM deficits represent a robust finding in adults with frontal and temporal epilepsy, but are also found in children with generalised seizures. Further research into ToM is needed, especially in children with epilepsy as early ToM may have cumulative, negative effects on development of social skills that continues into adulthood.     

A Place for Every Event and Every Event in Its Place: Memory for Locations and Activities by 4-Year-Old Children

Episodic memories are of specific events and experiences associated with particular times and places. Whereas memory for the temporal aspects of past events has been a focus of research attention, memory for the location in which events were experienced has been less fully investigated. The limited developmental research suggests that preschool-age children, in particular, may have difficulty remembering the location in which they experienced specific events. In 2 experiments, 4-year-old children engaged in 4 unique activities in 4 unique locations in and around a laboratory suite. In Experiment 1, the children had high levels of recall of the activities, the locations, and the conjunctions of activities and locations, implying that they had formed memory representations that featured activities bound in locations. In Experiment 2, we tested whether 1 element of the bound representation—the location of an activity—served as a reliable cue to recall of the other element—the activity itself. The test was positive, providing further evidence that 4-year-old children form mnemonic conjunctions of activities and locations. The results imply that important elements of episodic memory are available to young children.     

Cognitive Load Differentially Impacts Response Control in Girls and Boys with ADHD

Children with attention-deficit hyperactivity disorder (ADHD) consistently show impaired response control, including deficits in response inhibition and increased intrasubject variability (ISV) compared to typically-developing (TD) children. However, significantly less research has examined factors that may influence response control in individuals with ADHD, such as task or participant characteristics. The current study extends the literature by examining the impact of increasing cognitive demands on response control in a large sample of 81children with ADHD (40 girls) and 100 TD children (47 girls), ages 8–12 years. Participants completed a simple Go/No-Go (GNG) task with minimal cognitive demands, and a complex GNG task with increased cognitive load. Results showed that increasing cognitive load differentially impacted response control (commission error rate and tau, an ex-Gaussian measure of ISV) for girls, but not boys, with ADHD compared to same-sex TD children. Specifically, a sexually dimorphic pattern emerged such that boys with ADHD demonstrated higher commission error rate and tau on both the simple and complex GNG tasks as compared to TD boys, whereas girls with ADHD did not differ from TD girls on the simple GNG task, but showed higher commission error rate and tau on the complex GNG task. These findings suggest that task complexity influences response control in children with ADHD in a sexually dimorphic manner. The findings have substantive implications for the pathophysiology of ADHD in boys versus girls with ADHD.     

Community Research: The Lost Art of Unobtrusive Methods1

The use of unobtrusive methods, with special reference to community‐oriented research, is a lost art, despite their strong recommendation by Webb, Campbell, Schwartz, & Sechrest (1966) as means of supplementing reactive measures. The decline of unobtrusive measures seems to be related to the increased popularity and adherence to the doctrine of informed consent, the decrease in use of deception as a method, and the effort to conceptualize research subjects as cooperative participants. While the distaste for unobtrusive methods seems to reflect increased sensitivity toward ethics in research, the collection of partially reliable and partially valid knowledge continues, with considerable reliance on reactive measures.     

Social identity and the perception of history: cultural representations of Aotearoa/New Zealand

The context of intergroup relations in Aotearoa/New Zealand was investigated using perceptions of history by Maori (Polynesian‐descended) and Pakeha (European‐descended) samples from university and the general public. There was strong consensus that the Treaty of Waitangi was the most important event in New Zealand's history, but only Maori, the subordinate ethnic group, showed in‐group favouritism in their judgments regarding the Treaty. Pakeha, the dominant group, showed outgroup favouritism, and distanced themselves from past injustices using linguistic strategies. Maori students showed interest in their ethnic origins (ontogeny), rating the distant past and Polynesian history higher, and free‐recalling more events prior to European arrival than other groups; Maori in the general population shared a more similar perception of history to Pakeha. Both in‐group favouritism and ontogeny were found in sentence‐completion choices. Historical perceptions were strongly related to positions on current political issues. Results are related to social identity theory, social representations theory, and social dominance theory. Copyright © 1999 John Wiley & Sons, Ltd.     

Recalling a floor routine: the effects of skill and age on memory for order

Two studies were conducted to examine gymnasts' memory capabilities in relation to skill level (high and low) and age level (6–8 years and 14–16 years). The first experiment consisted of two trials performed 7 days apart. In the first trial, gymnasts were briefly exposed to a twelve‐element floor routine, and were then required to perform the routine in the same serial order. One week later they were again briefly presented the same sequence, but with the fifth and seventh elements missing. The task was to perform the sequence in order, including the missing elements. The second study involved three trials that were conducted on the same day. A ten‐element sequence was briefly presented on the first trial followed by an immediate test of that sequence. One hour later, participants were asked to perform the sequence again (delayed test). An hour following that, the sequence was again presented with two elements missing. The sequence had to be performed with the missing elements. The results indicate that serial position accuracy of a gymnastic floor routine improves with both age and experience, and that the older experienced gymnasts outperformed all the other gymnasts on all phases of the experiments. These results are interpreted within the Ericsson and Kintsch (1995) theory of Long‐term Working Memory. Copyright © 1999 John Wiley & Sons, Ltd.     

Do emotion-induced blindness and the attentional blink share underlying mechanisms? An event-related potential study of emotionally-arousing words

When two targets are presented within approximately 500 ms of each other in the context of rapid serial visual presentation (RSVP), participants’ ability to report the second target is reduced compared to when the targets are presented further apart in time. This phenomenon is known as the attentional blink (AB). The AB is increased in magnitude when the first target is emotionally arousing. Emotionally arousing stimuli can also capture attention and create an AB-like effect even when these stimuli are presented as to-be-ignored distractor items in a single-target RSVP task. This phenomenon is known as emotion-induced blindness (EIB). The phenomenological similarity in the behavioral results associated with the AB with an emotional T1 and EIB suggest that these effects may result from similar underlying mechanisms – a hypothesis that we tested using event-related electrical brain potentials (ERPs). Behavioral results replicated those reported previously, demonstrating an enhanced AB following an emotionally arousing target and a clear EIB effect. In both paradigms highly arousing taboo/sexual words resulted in an increased early posterior negativity (EPN) component that has been suggested to represent early semantic activation and selection for further processing in working memory. In both paradigms taboo/sexual words also produced an increased late positive potential (LPP) component that has been suggested to represent consolidation of a stimulus in working memory. Therefore, ERP results provide evidence that the EIB and emotion-enhanced AB effects share a common underlying mechanism.     

Integrated cross-network connectivity of amygdala,insula, and subgenual cingulate associated with facial emotion perception in healthy controls and remitted major depressive disorder

Emotion perception deficits could be due to disrupted connectivity of key nodes in the salience and emotion network (SEN), including the amygdala, subgenual anterior cingulate cortex (sgACC), and insula. We examined SEN resting-state (rs-)fMRI connectivity in rMDD in relation to Facial Emotion Perception Test (FEPT) performance. Fifty-two medication-free people ages 18 to 23 years participated. Twenty-seven had major depressive disorder (MDD) in remission (rMDD, 10 males), as MDD is associated with emotion perception deficits and alterations in rsfMRI. Twenty-five healthy controls (10 males) also participated. Participants completed the FEPT during fMRI, in addition to an 8-minute eyes-open resting-state scan. Seed regions of interest were defined in the amygdala, anterior insula and sgACC. Multiple regression analyses co-varied diagnostic group, sex and movement parameters. Emotion perception accuracy was positively associated with connectivity between amygdala seeds and regions primarily in the SEN and cognitive control network (CCN), and also the default mode network (DMN). Accuracy was also positively associated with connectivity between the sgACC seeds and other SEN regions, and the DMN, particularly for the right sgACC. Connectivity negatively associated with emotion perception was mostly with regions outside of these three networks, other than the left insula and part of the DMN. This study is the first to our knowledge to demonstrate relationships between facial emotion processing and resting-state connectivity with SEN nodes and between SEN nodes and regions located within other neural networks.     

A novel indirect method for capturing involuntary musical imagery under varying cognitive load

Involuntary musical imagery (INMI), i.e the internal experience of a repetitive musical fragment, is one of the most ubiquitous forms of spontaneous cognition. Findings regarding the relationship between INMI and cognitive load are conflicting. In the present study, 200 participants watched and evaluated two non-dialogue, music-only film trailers. Subsequently, they either closed their eyes for 5 min (baseline), or engaged in one of three dot tasks of varying challenge and attentional demand (low, medium, and high cognitive load). Finally, they completed a novel “Mind Activity Questionnaire”, which allows for indirect INMI sampling rather than direct questioning. The same questionnaire was completed 24 hours later. Overall, a significant negative linear trend was found. At baseline, 65% of people reported experiencing INMI. This rate decreased to 32.5% in the low load condition with further reductions observed in the medium and high conditions, which did not differ significantly from each other. INMI frequency and duration followed the same pattern as the induction rates. In the 24-hour follow-up, 21% of participants reported INMI experiences. This study supports the hypothesis that INMI occurrence, frequency, and duration relate to spare cognitive capacity and demonstrates an ecologically valid laboratory paradigm for covertly inducing and documenting INMI experiences.