Do age of onset and course of illness define biologically distinct groups within atypical depression?

Illness course separates patients with atypical depression into tricyclic responders and nonresponders as does perceptual asymmetry. The authors therefore investigated whether the course-of-illness parameters would define groups within atypical depression differing in brain laterality. Patients with atypical depression were assessed for illness course and brain laterality. Two patient groups were defined, 1 with onset prior to age 20 plus a very chronic course, and a 2nd group having later onset or less chronic illness. Patients reporting early onset of very chronic dysphoria showed significantly less right-ear (left-hemisphere) accuracy and also differed in characteristic perceptual asymmetry when compared to patients with later onset or less chronicity. Course of illness may usefully define more homogeneous depressive subgroups within atypical depression.     

Social dominance and ethical ideology: the end justifies the means?

Although many social psychological researchers have tried to identify the antecedents of unethical or immoral behavior, investigators have little considered the content of ethical beliefs that associate with important personality variables such as authoritarianism (B. Altemeyer, 1981, 1996) and social dominance orientation (SDO; J. Sidanius, 1993). Previous studies suggest that authoritarianism is associated with the rejection of relativistic standards for moral actions and--to a lesser extent--the idealistic belief that moral actions should not harm others (J. W. McHoskey, 1996). In the present study, 160 New Zealand University students completed measures of SDO (J. Sidanius), Right Wing Authoritarianism (RWA, B. Altemeyer, 1981), and two subscales of ethical ideology: Relativism and Idealism (D. R. Forsyth, 1980). As expected, SDO showed a negative relationship with Idealism, a belief that actions should not harm others. But, contrary to expectations, SDO showed no consistent association with relativism, a belief that the moralities of actions are not comparable. On the basis of those findings, people with high SDO might be described as "ruthless" in their pursuit of desirable goals and are indifferent about whether the morality of different actions can be compared or even matter.     

Putting personality in social context: extraversion, emergent leadership, and the availability of rewards

The present research tested relations between extraversion and emergent leadership among men in situations that differed in potential reward availability. Four-person groups of men engaged in a Leaderless Group Discussion (LGD) task and were randomly assigned to be evaluated by an attractive female observer, an attractive male observer, or not be evaluated. Evolutionary theories suggest that impressing a female evaluator in an intrasexually competitive situation should hold greater reward potential for men than impressing either a male evaluator or no evaluator. Accordingly, more extraverted men (who are more sensitive to reward cues) should display more group leadership when being evaluated by a woman than either a man or no one. Self-and peer ratings confirmed that more extraverted men were significantly more likely to emerge as leaders, but only in the female-evaluator condition. The results are discussed in terms of the interplay between personality, situational factors, and evolutionary principles.     

Strain and gender specific effects in the forced swim test: effects of previous stress exposure

The chronic mild stress (CMS) procedure was developed in rodents to target anhedonia, the core symptom of depressive melancholia. Stress exposure has been shown to induce a variety of physiological, biochemical and behavioral alterations associated with depression, although its anhedonic consequences as indexed by either sucrose intake and preference or thresholds for brain stimulation reward are less reliably observed. In the present study, we assessed the effects of six weeks of CMS on the latter measure in two strains of male and female rats subsequently challenged with an acute psychophysical stressor, forced swimming; their behavior in the swimming cylinder was evaluated on two consecutive days. While brain stimulation reward thresholds and response rates were unchanged by CMS exposure, significant differences in forced swim behaviors were observed between male control and CMS groups. In particular, male Long Evans rats with a history of CMS showed the largest decrease in the duration of active behaviors on the second test day, a pattern less evident in the Sprague-Dawley strain of rats, or in any of the female groups. The results suggest that the effects of depressogenic manipulations are strain and gender dependent, with male Long Evans rats most susceptible, as demonstrated by the selective reduction of struggling behaviors. Inclusion of multiple measures, including the forced swim test, would provide a better understanding of the psychopathological profile engendered by chronic exposure to mild stressors and its genetic specificity.     

Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing

A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-hippocampal interactions. Acetylcholine (ACh) release, a marker of memory-related activation, was measured in the hippocampus of PTD-treated and control rats prior to, during, and after spontaneous alternation test. During behavioral testing, all animals displayed increases in ACh release. However, both the percent increase of ACh release during spontaneous alternation testing and the alternation scores were higher in control rats relative to PTD-treated rats. Thus, when rats are tested on a task with demands dependent on the hippocampus, it appears that the hippocampus is not fully activated after diencephalic damage.     

Understanding metaphor: A relational frame perspective

The current article presents a basic functional-analytic interpretation of metaphor. This work involves an extension of Skinner's (1957) interpretation of metaphor using relational frame theory (RFT). A basic RFT interpretation of a particular metaphor is outlined, according to which the metaphor acquires its psychological effects when formal stimulus dimensions are contacted via the derivation of arbitrary stimulus relations. This interpretation sees the metaphor as involving four elements: (a) establishing two separate equivalence relations, (b) deriving an equivalence relation between these relations, (c) discriminating a formal relation via this equivalence-equivalence relation, and (d) a transformation of functions on the basis of the formal relation discriminated in the third element. In the second half of the paper, a number of important issues with regard to the RFT interpretation of metaphor are addressed.     

Phonologically related lexical repetition disorder: a case study

Errors of repetition in aphasia are most often nonword substitutions. Phonologically related lexical errors, or formal errors, are real-word substitutions that overlap with target words in sound. In the present research we present the case of an aphasic patient, MMB, who produced an unusually high rate of formal paraphasias in repetition. Six experiments were conducted to investigate the combination of impairments contributing to MMB's pattern of repetition and to test the predictions made by two theories of formal errors. MMB's formal errors in repetition were influenced by target frequency, but not by target length or imageability. Formal errors tended to be more frequent than their targets and showed greatest phonological overlap with targets at initial consonant. These findings provided partial support for Martin and Saffran's fully interactive spreading activation account of formal errors and did not support Blanken's phonological interactive encoding account. In Experiment 6, the effect on repetition of increasing auditory verbal short-term memory (AVSTM) demands was examined using a paired word repetition experiment. Under these conditions, MMB produced semantic paraphasias for the first time, providing strong support for the Martin-Saffran hypothesis that phonologically related, and semantic, lexical repetition disorders lie on a continuum of severity moderated by the degree of AVSTM impairment.     

A neuron doctrine in the philosophy of neuroscience

Many neuroscientists and philosophers endorse a view about the explanatory reach of neuroscience (which we will call the neuron doctrine) to the effect that the framework for understanding the mind will be developed by neuroscience; or, as we will put it, that a successful theory of the mind will be solely neuroscientific. It is a consequence of this view that the sciences of the mind that cannot be expressed by means of neuroscientific concepts alone count as indirect sciences that will be discarded as neuroscience matures. This consequence is what makes the doctrine substantive, indeed, radical. We ask, first, what the neuron doctrine means and, second, whether it is true. In answer to the first question, we distinguish two versions of the doctrine. One version, the trivial neuron doctrine, turns out to be uncontroversial but unsubstantive because it fails to have the consequence that the nonneuroscientific sciences of the mind will eventually be discarded. A second version, the radical neuron doctrine, does have this consequence, but, unlike the first doctrine, is highly controversial. We argue that the neuron doctrine appears to be both substantive and uncontroversial only as a result of a conflation of these two versions. We then consider whether the radical doctrine is true. We present and evaluate three arguments for it, based either on general scientific and philosophical considerations or on the details of neuroscience itself, arguing that all three fail. We conclude that the evidence fails to support the radical neuron doctrine.     

Corporal Punishment by American Parents: National Data on Prevalence, Chronicity, Severity, and Duration, in Relation to Child and Family Characteristics

We present data on corporal punishment (CP) by a nationally representative sample of 991 American parents interviewed in 1995. Six types of CP were examined: slaps on the hand or leg, spanking on the buttocks, pinching, shaking, hitting on the buttocks with a belt or paddle, and slapping in the face. The overall prevalence rate (the percentage of parents using any of these types of CP during the previous year) was 35% for infants and reached a peak of 94% at ages 3 and 4. Despite rapid decline after age 5, just over half of American parents hit children at age 12, a third at age 14, and 13% at age 17. Analysis of chronicity found that parents who hit teenage children did so an average of about six times during the year. Severity, as measured by hitting the child with a belt or paddle, was greatest for children age 5–12 (28% of such children). CP was more prevalent among African American and low socioeconomic status parents, in the South, for boys, and by mothers. The pervasiveness of CP reported in this article, and the harmful side effects of CP shown by recent longitudinal research, indicates a need for psychology and sociology textbooks to reverse the current tendency to almost ignore CP and instead treat it as a major aspect of the socialization experience of American children; and for developmental psychologists to be cognizant of the likelihood that parents are using CP far more often than even advocates of CP recommend, and to inform parents about the risks involved.     

Predictors of therapeutic response to treatments for depression: a review of electrophysiologic and dichotic listening studies

There are few clinical or biologic predictors of response to treatments for depression. This article reviews growing evidence that electrophysiologic and neurocognitive measures of brain function may be of value as predictors of therapeutic response to antidepressants. Initial studies using dichotic listening, quantitative electroencephalography, or event-related brain potential measures have found differences between treatment responsive and nonresponsive subgroups of depressed patients. The neurophysiologic basis for these differences and the potential clinical utility of electrophysiologic and dichotic predictors of treatment outcome remain to be determined in future studies.