Fostering integrity in research: Definitions, current knowledge, and future directions

Over the last 25 years, a small but growing body of research on research behavior has slowly provided a more complete and critical understanding of research practices, particularly in the biomedical and behavioral sciences. The results of this research suggest that some earlier assumptions about irresponsible conduct are not reliable, leading to the conclusion that there is a need to change the way we think about and regulate research behavior. This paper begins with suggestions for more precise definitions of the terms "responsible conduct of research," "research ethics," and "research integrity." It then summarizes the findings presented in some of the more important studies of research behavior, looking first at levels of occurrence and then impact. Based on this summary, the paper concludes with general observations about priorities and recommendations for steps to improve the effectiveness of efforts to respond to misconduct and foster higher standards for integrity in research.     

Selective visual attention and perceptual coherence

Conscious perception of the visual world depends on neural activity at all levels of the visual system from the retina to regions of parietal and frontal cortex. Neurons in early visual areas have small spatial receptive fields (RFs) and code basic image features; neurons in later areas have large RFs and code abstract features such as behavioral relevance. This hierarchical organization presents challenges to perception: objects compete when they are presented in a single RF, and component object features are coded by anatomically distributed neuronal activity. Recent research has shown that selective attention coordinates the activity of neurons to resolve competition and link distributed object representations. We refer to this ensemble activity as a "coherence field", and propose that voluntary shifts of attention are initiated by a transient control signal that "nudges" the visual system from one coherent state to another.     

A low-cost, MR-compatible olfactometer

We present a design for an olfactometer, suitable for fMRI experiments, that can be constructed at extremely low cost. The olfactometer presents odors directly to the nose via a nasal cannula at unobtrusively low flow velocities, with no large assemblies required on or near the subject’s face. The olfactometer can be controlled manually, or by computer via a serial interface. A validation study verified that the olfactometer reliably presents odors to test subjects. Errors and response latency times decreased with increased flow rate in an orderly manner, as expected.     

Race, family interactions, and patient stabilization in schizophrenia

This study examined family interactions associated with a failure to stabilize in schizophrenia. Fifty-eight patient and parent dyads completed a problem-solving task soon after an acute episode. Stabilization was assessed over the following 6 months. African American patients' self-initiated discussions of substance use and increased anxiety during the interaction were associated with a failure to stabilize. Nonstabilization in White patients was associated with high levels of both the patients' odd thinking and the parents' criticism. White patients who were depressed during the interaction were also less likely to stabilize. Findings suggest that family relationships may play in important role in determining whether patients stabilize after an acute episode. Results also point to the importance of cultural factors in predicting patient stabilization.     

Clinical significance methods: a comparison of statistical techniques

Clinically significant change refers to meaningful change in individual patient functioning during psychotherapy. Following the operational definition of clinically significant change offered by Jacobson, Follette, and Revenstorf (1984), several alternatives have been proposed because they were thought to be either more accurate or more sensitive to detecting meaningful change. In this study, we compared five methods using a sample of 386 outpatients who underwent treatment in routine clinical practice. Differences were found between methods, suggesting that the statistical method used to calculate clinical significance has an effect on estimates of meaningful change. The Jacobson method (Jacobson & Truax, 1991) provided a moderate estimate of treatment effects and was recommended for use in outcome studies and research on clinically significant change, but future research is needed to validate this statistical method.     

The development of therapeutic alliance during psychological assessment: patient and therapist perspectives across treatment

We examined the impact of patient- and therapist-rated alliance developed during psychological assessment on the subsequent alliance measured early and late in formal psychotherapy. We hypothesized that a working alliance developed during psychological assessment conducted from a collaborative therapeutic model of assessment (TMA; Finn & Tonsager, 1992, 1997; Fischer, 1994) between the patient and therapist would carry into formal psychotherapy. We also hypothesized that alliance for those patients receiving a TMA would be significantly greater than patients receiving psychological testing as usual. To test this hypothesis, we administered the Combined Alliance Short Form-Patient Version (Hatcher & Barends, 1996) and the Combined Alliance Short Form-Therapist Version (Hatcher, 1999) to a sample of outpatients and their therapists at the end of the assessment feedback session, early, and late in psychotherapy. The hypotheses were supported as alliance scales rated at the assessment feedback session demonstrated positive and significant relationships with alliance throughout formal psychotherapy and in relation to a control group. The clinical utility and research implications of these findings are discussed.