Remote Odor Memory in Alzheimer's Disease: Deficits as Measured by Familiarity

Deficit in olfaction and remote nonolfactory memory in Alzheimer's disease (AD) motivated the present study of remote memory for odors and faces, operationally defined as rated familiarity, in patients with AD and controls. Uncommon engineering symbols were rated for familiarity to ensure task comprehension. Results showed that patients with AD rate odors, but not faces, as significantly less familiar than do controls, which is indicative of deficit in remote odor memory. Follow-up testing 1 year later again showed this result. Poor odor-detection sensitivity in patients, with AD, but lack of significant correspondence between sensitivity and familiarity, suggests an existing but limited effect of sensitivity on familiarity. The findings provide further evidence that olfaction may be a useful modality for early identification of AD.     

Expression of Fos and Jun Proteins Following Passive Avoidance Training in the Day-Old Chick

It has been shown previously that the immediate-early genes, c-fos and c-jun mRNA are induced in the 1-day-old chick forebrain after one-trial passive avoidance training in which chicks learn to avoid pecking at a bitter-tasting bead. Here, we have studied the expression of their proteins using antibodies to Fos and Jun. Western blotting disclosed two immunoreactive bands for the anti-Fos antibody (47 and 54 kD) and two immunoreactive bands for the anti-Jun antibody (39 and 54 kD). Two hours post-training there was an increase in the number of Fos-positive stained nuclei in right intermediate medial hyperstriatum ventrale (IMHV) (P<0.01), left IMHV (P<0.05), right lobus parolfactorius (LPO) (P<0.025) and left LPO (P<0.05) of birds trained on the bitter bead compared with controls that had pecked a water-coated bead. Staining for Jun protein was significantly greater in the right LPO of trained chicks (P<0.01). Other forebrain regions showed no increase over quiet control levels. The findings are discussed in the context of the cascade of events involved in passive avoidance memory consolidation in the day-old chick.     

Risk of sexual revictimization: A theoretical model

Survivors of child sexual abuse suffer serious short- and long-term psychological consequences. Sexual revictimization as an adult is one of the consequences that has been reported. At present, there is no theoretical model identifying the risk factors that result in child sexual abuse survivors being at greater risk of experiencing an adult sexual assault. The proposed model is designed to integrate existing research, stimulate further empirical work, and eventually aid in the development of a program to prevent revictimization. The variables hypothesized to play a mediating role in the pathway to revictimization include: severe psychological symptoms as a consequence of the child sexual abuse, poor coping styles, an insecure attachment style, hyperfemininity, delinquent behavior, drug use, and high risk sexual behavior.     

Comorbidity of Hyperactivity-Impulsivity-Inattention and Conduct Problems: Risk Factors in Social, Affective, and Academic Domains

Children showing a comorbid behavior pattern of hyperactivity-impulsivity-inattention and conduct problems (HIA + CP) were contrasted to children having only an internalizing and externalizing behavior pattern (I + E) and matched controls. Children displaying the HIA + CP behavior pattern were at greater risk on a number of outcome measures in social and academic domains beginning in Grade 3 and continuing into Grade 4. The most marked differences among the three groups were found on peer measures of rejection and friendship and teacher ratings of social skills. On average, almost two-thirds of the HIA + CP group were rejected by their peers compared to one-third of the I + E group and only 12.5% controls. Over 70% of the HIA + CP group had no reciprocated friendships from Grade 3 to Grade 4 compared to less than half of the I + E group and approximately one-fourth of controls. Contrary to much theorizing in the literature, the HIA + CP and I + E groups showed average levels of academic self-concept and did not differ from controls in on measures of social self-concept and academic self-concept and general self-esteem. These findings were interpreted in light of positive illusory biases and the established link between aggressive behavior and egotism. The current article offers partial support for Lynam's (1996) notion of the fledgling psychopath.     

Nordenfelt's Theory of Disability

This paper is an attempt to provide a critical evaluation of the theory of disability put forward by Lennart Nordenfelt. The paper is in five sections. The first sets out the main elements of Nordenfelt's theory. The second section elaborates the theory further, identifies a tension in the theory, and three kinds of problems for it. The tension derives from Nordenfelt's attempt to respect two important but conflicting constraints on a theory of health. The problems derive from characterisation of the goals of persons; the difficulty which Nordenfelt has in respecting the plausible view that there is a distinction between illness and disability; and the presence in the theory of other strongly counter-intuitive implications. In section three a defence of Nordenfelt is attempted from within the resources available within his own theory. This defence seeks to exploit his distinctions between a person who is ill and one who is generally disabled and that between first- and second-order disabilities. However, it is concluded that there are insufficient resources within Nordenfelt's theory to fend off the criticisms developed in section two. The fourth section of the paper attempts a defence of Nordenfelt. It is claimed that introduction of the concept of capacity helps to explain differences between problem cases in the theory. Finally, it is shown that at least two important constraints on any theory of disability emerge from the preceding discussion.     

MULTICOMPONENT INTERVENTION FOR AGITATED BEHAVIOR IN A PERSON WITH ALZHEIMER'S DISEASE

We evaluated a multicomponent intervention for agitated behavior in a man with probable Alzheimer's disease. Hypotheses about variables controlling his agitated behavior guided intervention design. Based on staff interviews, direct observations, and brief experimental probes, intervention components were chosen to increase rate of reinforcement and decrease aversive aspects of his job. Intervention reduced agitated behavior without disrupting his work rate.     

SCHEDULE EFFECTS OF NONCONTINGENT REINFORCEMENT ON ATTENTION-MAINTAINED DESTRUCTIVE BEHAVIOR IN IDENTICAL QUADRUPLETS

Noncontingent reinforcement (NCR), a response-independent schedule for the delivery of reinforcement, has been found to be effective in reducing behavior when the reinforcer delivered is responsible for behavioral maintenance. In this study, dense and lean schedules of response-independent attention were compared to determine whether it is necessary to begin with a dense schedule before fading to a lean schedule, or whether treatment would be as effective using a lean schedule at the outset. The subjects were 5-year-old identical quadruplets diagnosed with mental retardation and pervasive developmental disorder who displayed destructive behavior that was maintained by social attention. NCR was selected partially because it is not very labor intensive and could be implemented by a single mother simultaneously with all 4 children. Using a combination multielement and multiple baseline design, it was found that (a) a dense schedule of response-independent reinforcement (i.e., fixed-time 10 s) resulted in immediate and dramatic reductions in destructive behavior with no evidence of an extinction burst, and (b) an equivalent reduction in destructive behavior was achieved with a lean schedule of response-independent reinforcement (fixed-time 5 min) only after a systematic fading procedure was implemented. The findings suggest that the effectiveness of NCR may be dependent on the use of a dense schedule initially, and that systematic fading can increase the effectiveness of a lean schedule.     

Predicting the Outcomes of Disputes: Consequences for Disputant Reactions to Procedures and Outcomes1

Third parties in dispute settings often make predictions to disputants regarding the likely outcome of their dispute at arbitration. However, virtually no research has examined the impact of predictions on disputant satisfaction with dispute resolution procedures and outcomes. One explanation for the lack of attention to this variable may be that current theorizing regarding dispute resolution procedures is too narrowly stated to incorporate this procedural variation. Theories about predictability from nondispute settings are used to generate hypotheses regarding the consequences of such outcome prediction. In a laboratory setting, disputants prepared arguments in anticipation of an arbitration hearing. Prior to the arbitrator's decision, the experimenter read the disputants' arguments and made a prediction regarding the arbitrator's decision. Their arguments were then presented to an arbitrator who imposed a binding decision. Dependent measures include the disputants' anxiety while awaiting the arbitrator's decision, and their postdecision satisfaction with dispute resolution procedures and outcomes. Internal analyses support the hypothesis that outcome prediction has benefits for disputants' predecision coping, ratings of procedural fairness, and satisfaction judgments. Also, as hypothesized, correct predictions produced greater postdecision satisfaction with outcomes and decision-makers than did incorrect predictions.     

Word frequency and list composition effects in associative recognition and recall

The effects of list composition and word frequency on cued recall, associative recognition, and item recognition were examined in three experiments For pure-frequency lists, cued recall and associative recognition show better performance on common high-frequency (HF) words than on rare low-frequency (LF) words. Item recognition, however, shows an advantage for LF words. In mixed lists, consisting of half HF and half LF words, the HF advantage in cued recall disappeared; however, the word frequency effects in item and associative recognition were unchanged. These results are inconsistent with explanations based on differential attention or co-rehearsal of KF and LF words. However, the results are consistent with list strength results which show that recognition is insensitive to strength-based list composition, but that recall is sensitive to list composition.