脊柱侧弯手术治疗进展

随着医学技术的发展,脊柱侧弯的治疗方法也在不断的进步。针对其治疗方法的改变,提出以下思考和分析：（1）脊柱侧弯的治疗方法遵循着螺旋式上升,曲折式前进的发展过程;（2）运用适度原则和最优化原则,为患者制定个体化治疗方案;（3）运用运动发展的眼光即动态性原则来观察和解决脊柱侧弯手术治疗中存在的问题。     

缺血性脑血管病的血管内治疗热点

缺血性脑血管疾病的血管内治疗目前已成为脑血管病治疗研究的热点之一,并以其微创的理念、较好的疗效得到广泛认可,本文重点介绍缺血性脑血管病中支架辅助狭窄扩张、动静脉介入溶栓以及静脉窦血栓形成的发展现状以及存在的问题,并对介入技术在缺血性脑血管病中应用的未来发展方向,作了简要回顾和展望。     

基于机体反馈调控保护扭转肿瘤治疗思路

肿瘤的临床治疗经过漫长积极探索研究,中西医疗效均未取得成就性突破,本文穿越时空隧道,基于人类亿万年适应环境生存生物进化历程形成的精细反馈调控保护视角,循证机体实施反馈调控保护顽强延续生命依据,结合肿瘤病理生理机制,剖析肿瘤形成原因,追溯肿瘤临床治疗误区,扭转肿瘤治疗思路,引领肿瘤治疗新路径。     

冠脉介入治疗时期氯吡格雷抵抗的认识与思考——抓住本质，全面获益

急性冠脉综合征已步入药物洗脱支架进行血运重建的时期,双联抗血小板治疗是接受PCI治疗的常规手段。临床发现部分患者不能从氯吡格雷治疗中获益,存在氯吡格雷抵抗的现象。笔者就氯吡格雷抵抗的发生机制、临床意义及治疗对策进行描述,反映相关研究的趋势和方向,为未来更优化抗血小板治疗提出一种策略。     

《乾》卦爻辞与周文王克商方略

《乾》卦爻辞的思想与周文王克商的整体战略有许多契合之处,如:“潜龙勿用”,与文王根据实力采取战略守势;“见龙在田”,与文王对西土方国的团结怀柔;“夕惕若厉”,与文王小心翼翼地臣事段商王朝;“或跃在渊”,与文王对大邑商发动战略进攻;“飞龙在天”,与文王谋划灭商的战略决战;“亢龙有悔”,与文王认识到攻取之道不可久用;“群龙无首”,与文王设计从武功向文治的战略转移等,皆有相通相合的地方.《乾》卦爻辞与文王克商方略之间的诸多契合表明,殷周之际王朝更迭的沧桑巨变,深刻地影响了《乾》卦爻辞的撰作.其中,文王克商的方略及其过程,应是《乾》卦最为重要的思想渊源之一.     

信任及其对公共财物两难博弈中合作行为影响

社会两难的行为动机研究认为,害怕和贪婪是人们选择不合作的原因。信任的心理学研究为社会两难的合作行为提供了另一种观点,即害怕被利用的背后实际上体现了博弈者对对方的信任的缺失。鉴于传统社会两难范式存在难以区分信任和合作两个因素的问题,本研究设计了“信任一合作”二阶段模拟实验,通过操作重复信托博弈中的信息反馈,研究虚拟多人信托博弈中初始信任和基于经验的信任对随后的公共财物两难博弈中合作行为的影响,结果发现：（1）初始信任对基于经验的信任的建立具有一定的积极影响,但是它对合作行为的作用远不如随后的基于经验的信任;（2）基于经验的信任水平高的被试在随后的公共财物两难博弈中也表现出较高的合作行为。     

意识锚定加工对潜在锚定加工的影响

潜在锚定效应是指阈限下的启动锚定数字导致的锚定效应现象。本研究通过2个实验探讨了意识锚定加工对潜在锚定加工的影响。实验一考察了意识层面的外在锚对潜在锚定效应产生的影响,实验二则进一步探讨了意识层面的自发锚对潜在锚定效应的影响。实验一发现,在不存在外在锚时高锚与低锚的估计有显著性差异;实验二发现,在不存在自发锚时高锚与低锚的估计有显著性差异。研究结果表明,外在锚定加工和自发锚定加工的效应都强于潜在锚定加工。     

The difficult mountain: enriched composition in adjective–noun phrases

When readers need to go beyond the straightforward compositional meaning of a sentence (i.e., when enriched composition is required), costly additional processing is the norm. However, this conclusion is based entirely on research that has looked at enriched composition between two phrases or within the verb phrase (e.g., the verb and its complement in . . . started the book . . .) where there is a discrepancy between the semantic expectations of the verb and the semantics of the noun. We carried out an eye-tracking experiment investigating enriched composition within a single noun phrase, as in the difficult mountain. As compared with adjective–noun phrases that allow a straightforward compositional interpretation (the difficult exercise), the coerced phrases were more difficult to process. These results indicate that coercion effects can be found in the absence of a typing violation and within a single noun phrase.     

The tail-elicited tail withdrawal reflex of Aplysia is mediated centrally at tail sensory-motor synapses and exhibits sensitization across multiple temporal domains

The defensive withdrawal reflexes of Aplysia californica have provided powerful behavioral systems for studying the cellular and molecular basis of memory formation. Among these reflexes the tail-elicited tail withdrawal reflex (T-TWR) has been especially useful. In vitro studies examining the monosynaptic circuit for the T-TWR, the tail sensory-motor (SN-MN) synapses, have identified the induction requirements and molecular basis of different temporal phases of synaptic facilitation that underlie sensitization in this system. They have also permitted more recent studies elucidating the role of synaptic and nuclear signaling during synaptic facilitation. Here we report the development of a novel, compartmentalized semi-intact T-TWR preparation that allows examination of the unique contributions of processing in the SN somatic compartment (the pleural ganglion) and the SN-MN synaptic compartment (the pedal ganglion) during the induction of sensitization. Using this preparation we find that the T-TWR is mediated entirely by central connections in the synaptic compartment. Moreover, the reflex is stably expressed for at least 24 h, and can be modified by tail shocks that induce sensitization across multiple temporal domains, as well as direct application of the modulatory neurotransmitter serotonin. This preparation now provides an experimentally powerful system in which to directly examine the unique and combined roles of synaptic and nuclear signaling in different temporal domains of memory formation.     

Frontal pole cortex: encoding ends at the end of the endbrain

Considerable neuroimaging research in humans indicates that the frontal pole cortex (FPC), also known as Brodmann area 10, contributes to many aspects of cognition. Despite these findings, however, its fundamental function and mechanism remain unclear. Recent neurophysiological results from the FPC of monkeys have implications about both. Neurons in the FPC seem to encode chosen goals at feedback time and nothing else. Goals, the places and objects that serve as targets for action, come in many forms and arise from many cognitive processes. The FPC's signal, although surprisingly simple for neurons at the apex of a prefrontal hierarchy, could promote learning about which kinds of goals and goal-generating processes produce particular costs and benefits, thereby improving future choices.