The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

Analgesic and opioid involvement in the shock-elicited activity and escape deficits produced by inescapable shock

Three experiments examined the involvement of analgesic processes and endogenous opioids in the production of the shuttlebox escape acquisition and unconditioned activity deficits which follow exposure to inescapable shock. Experiment 1 found that the opiate antagonist naltrexone administered before the inescapable shock session interfered with the shuttlebox escape acquisition deficit which would normally follow. Experiment 2 found naltrexone to completely prevent the unconditioned activity deficit. The final experiment revealed that dexamethasone, a synthetic glucocorticoid which abolishes the analgesia produced by inescapable shock, reversed the activity deficit. These results indicate that endogenous opioids may be involved in the production of both the escape acquisition and activity deficits. They also suggest that the analgesia produced by these opioids may participate in the mediation of the activity deficit, even though analgesia is not involved in producing the shuttlebox acquisition deficit.     

The relation between proximity and brightness similarity in dot patterns

The Gestalt studies demonstrated the tendency to visually organize dots on the basis of similarity, proximity, and global properties such as closure, good continuation, and symmetry. The particular organization imposed on a collection of dots is thus determined by many factors, some local, some global. We discuss computational reasons for expecting the initial stages of grouping to be achieved by processes with purely local support. In the case of dot patterns, the expectation is that neighboring dots are grouped as a function of proximity and similarity of contrast, by processes that are independent of the overall organization and the various global factors. We describe experiments that suggest a purely local relationship between proximity and brightness similarity in perceptual grouping.     

Evidence against visual integration across saccadic eye movements

One of the classic problems in perception concerns how we perceive a stable, continuous visual world even though we view it via a temporally discontinuous series of eye movements. Previous investigators have suggested that our perception of a stable visual environment is due to anintegrative visual buffer, a special memory store capable of fusing the visual contents of successive fixations according to their environmental coordinates. In this paper, three experiments are reported that attempted to demonstrate the existence of an integrative visual buffer. The experimental procedure required subjects to mentally fuse two halves of a dot matrix presented in the same spatial region of a display, but separated by an eye movement so that each half was viewed only during one fixation. Thus, subjects had to integrate packets of visual information that had the same environmental coordinates, but different retinal coordinates. No evidence was found in any experiment for the fusion of visual information from successive fixations in memory, leaving the status of the integrative visual buffer in serious doubt.     

Differences in temporal appearance associated with activity in the chromatic and achromatic systems

The temporal appearances of spatially coincident increments that activate the chromatic or achromatic system are different. Whereas near-threshold stimuli that are detected by the chromatic system appear to come on gradually, increments detected by the achromatic system appear to flash or step on. This difference in perception is consistent with previous reports that show differences in the temporal properties of the two systems.     

An Apple II package for computer-assisted telephone interviewing

This paper describes an Apple II (an Apple-compatible) microcomputer package for a computer-assisted telephone interviewing (CATI) system. This system generates random telephone numbers within any number of exchanges that the user supplies, automatically dials the telephone, prompts the interviewer with each question, and records and permanently saves each response. It also provides a printed copy of the collected data by frequency of response in each question category. The Apple II CATI package is readily available, inexpensive, and easy to program in the BASIC language.     

Parameter estimation in latent trait models

Latent trait models for binary responses to a set of test items are considered from the point of view of estimating latent trait parameters=( ₁, , _n ) and item parameters=( ₁, , _k ), where _j may be vector valued. With considered a random sample from a prior distribution with parameter, the estimation of (, ) is studied under the theory of the EM algorithm. An example and computational details are presented for the Rasch model.This work was supported by Contract No. N00014-81-K-0265, Modification No. P00002, from Personnel and Training Research Programs, Psychological Sciences Division, Office of Naval Research. The authors wish to thank an anonymous reviewer for several valuable suggestions.