Increased eating in rats deprived of running

Daily food intake in rats was temporarily reduced by the introduction of an activity wheel and temporarily increased by the subsequent removal of the wheel. When this outcome is coupled with the positive relation between food deprivation and running—and food deprivation is seen as a loss of eating rather than as a physiological state—there is the suggestion that the total behavior output of the organism may be regulated as such. Specifically, when the rat is deprived of a behavior that recurrently comprises a large part of its total daily activity, an increase may occur in some other behavior.     

Punishment of SΔ responding of humans in conditional matching to sample by time-out

Human subjects were intermittently reinforced with money for performing correctly on a conditional matching-to-sample task. The matching performance was examined as a function of a) the duration of Time-Outs (TOs) which followed every incorrect response and b) the frequency (FR value) with which TOs followed incorrect responses. The matching accuracy increased with longer TOs and decreased with less frequent presentation of TOs.     

Effects of deprivation upon counting and timing in rats

Two procedures were used in an investigation of the effects of deprivation upon counting and timing. Under the first procedure, fixed minimum interval (FMI), the rat received liquid reinforcement every time it pressed bar B after having waited a minimum of 5 sec following a press on bar A. Under the second procedure, fixed consecutive number (FCN), reinforcement was delivered every time the rat pressed bar B following a run of at least four consecutive responses on bar A.

Water deprivation was varied over a set of values ranging from 4 to 56 hr. Deprivation had almost no effect on the waiting time in the FMI procedure, or on the number of responses per run in the FCN procedure. With both procedures, increasing deprivation shortened the pause between reinforcement and the next response. In the FCN procedure, the speed with which the runs were executed increased with increasing deprivation, although the number of responses in these runs was relatively unaffected.

     

Generalization gradients of inhibition following auditory discrimination learning

A more direct method than the usual ones for obtaining inhibitory gradients requires that the dimension of the nonreinforced stimulus selected for testing be orthogonal to the dimensions of the reinforced stimulus. In that case, the test points along the inhibitory gradient are equally distant from the reinforced stimulus. An attempt was made to realize this condition by obtaining inhibitory gradients along the frequency dimension of a pure tone after discrimination training in which the nonreinforced stimulus was a pure tone (or tones), and the reinforced stimulus was either white noise or the absence of a tone. The results showed that some degree of specific inhibitory control was exerted by the frequency of the tone, although the gradients were broad and shallow in slope.

A further experiment was conducted to see whether the modification of an excitatory gradient resulting from training to discriminate neighboring tones could arise from a simple interaction of inhibitory and excitatory gradients. The results indicated that it could not, since discrimination training produced a concentration of responding in the vicinity of the reinforced stimulus which cannot be derived from any plausible gradient of inhibition.

     

A simple histological technique for localizing electrode tracks and lesions within the brain.

Histological procedures are necessary in brain stimulation or lesion work to determine the neural area which has been stimulated or damaged. Preparation of brain tissue often involves embedding and staining techniques that require specialized training, and the expense of a technician and a large assortment of special apparatus and supplies. In addition, the results of such techniques are unavailable for at least several days. A photographic method, which requires little special skill and a minimal amount of apparatus, is described here. Results can be available within minutes after the subject is sacrificed. This method has been shown to be adequate for the gross determination of lesion boundaries and electrode or cannula tip loci in brains of rats, cats, and squirrel monkeys.     

Several methods for teaching serial position sequences to monkeys

Three keys were available for monkeys to press. The objective was to teach the animals to press the keys in sequences up to 10 members in length. With fading procedures, a light that cued the correct key at a given serial member of the sequence faded out slightly each time the animal selected it, and became slightly brighter after the animal made an error at that sequence member. The correct keys were faded out, starting from the end of the sequence and proceeding toward the beginning. With control procedures, the cue lights were turned off suddenly, rather than being faded gradually. In almost every instance, the animals learned a longer series of unlighted key positions with the fading procedures than they did when each key-light was turned off suddenly. Also, requiring the animals to press a series of keys cued by lights before they could reach the sequence members they were to learn hampered them in learning the later serial members. By using several different sequences, it was possible to replicate these findings within the individual animal.     

An inexpensive electro-fistular swivel for negative feedback control of self-stimulation

A swivel was developed for concurrent intraorganismic fluid injection and intracranial electrical stimulation of the unrestrained rat. Effects of various intragastric injections on bar-pressing maintained by electrical stimulation of the hypothalamus were studied. In some subjects, intragastric injections of either water or milk decreased the rate of responding. This decrease resulted from pauses in responding rather than from decreases in the local rates of responding. The decrement in responding occurred at a lower gastric volume during milk injection than during water injection. In other subjects, however, neither water, milk, nor 32% sucrose injections affected the rate of self-stimulation.