Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Macro- and microlevel factors related to sense of community: The case of temporary neighborhoods in Israel

This study examines macro and micro factors influencing the development of sense of community (Davidson & Cotter, 1980) in two different populations (immigrants and veterans) in new temporary neighborhoods in Israel. At the macrolevel, the major factors examined were population size, population density, number of dwelling units in the site, urbanity of the area, ethnic heterogeneity, and peripheriality of the region. Three kinds of variables were examined on the microlevel: (a) personal attitudes: evaluation of the dwelling unit and satisfaction with public services; (b) social networks; and (c) sociodemographic characteristics. Data were collected from 242 immigrants from the former USSR and from 60 Israeli veterans, residing in 5 different sites. Two different patterns of predictors of sense of community emerged in the two different samples. In the veteran sample, only one macrolevel variable entered the stepwise analysis equation: the number of dwelling units in the site. In the immigrant sample, three significant microlevel factors entered the equation: evaluation of the dwelling unit, external network, and age. The data thus suggest that the major determinant factors underlying sense of community vary for different groups of people. The paper is based on a study initiated and financed by the Ministry of Housing and Construction, the Unit of Social Policy, Israel.     

Maternal stress and pituitary-adrenal manipulations during pregnancy in rats: effects on morphology and sexual behavior of male offspring.

The purpose of the present study was to determine whether the demasculinizing and feminizing effects of prenatal stress (i.e., stress applied to the mother during pregnancy) in rats reported previously are mediated by activation of the maternal pituitary-adrenal axis. Neither whole-body restraint, with or without hyperthermia, nor ACTH treatment during the last third of gestation had any reliable effect on masculine or feminine sexual behavior in male Sprague-Dawley offspring, although these treatments produced maternal pathology and evidence of maternal adrenocorticoid release. Significant littermate similarity was found for almost every morphological and behavioral measure. Failure to control for the litter variable may account for many previously reported effects of prenatal stress on sexual behavior in rats. The discrepancy between the present and earlier findings is discussed in terms of methodological and theoretical considerations.     

Attention to important versus trivial tasks and salience of fatigue-related symptoms for coronary prone individuals

The present study tested the hypothesis that individuals with the Type A coronary prone behavior pattern focus their attention more on important tasks, and less on trivial tasks than do Type B's. The study used a paradigm in which some subjects worked on math problems (important task) and rated intervening mood items (trivial task), whereas others rated mood items they were to memorize (important task) and worked on intervening math problems (trivial task). All subjects were later tested on recall of mood items. Results indicated that Type A's performed better on math problems and recalled more fatigue-related mood items when the task was important than when it was trivial; for Type B subjects, there was no difference in the number of math problems solved correctly or number of mood items recalled between important and trivial task conditions. Moreover, Type A's reported greater fatigue when mood recall was the important task than when math was the important task, whereas fatigue ratings of Type B's did not differ across these conditions. The findings suggest that Type A's suppress their attention to fatigue-related symptoms only when symptoms are not the objects of focus.     

Spacing judgments as an index of integration from context-induced relational processing: Implications for the free recall of ambiguous prose passages

The effect of information integration on the recall of ambiguous prose passages was investigated. In Experiment 1, subjects read ambiguous passages that were difficult to comprehend without titles. In judging the relative positions in the passages of pairs of test sentences, subjects performed better when they read passages headed by a suitable title than when they read untitled passages or received a title at the time of testing. In Experiment 2, subjects provided with a title at encoding also better discriminated complete old sentences from foils composed of fragments of two different old sentences than did subjects provided with no titles or with titles at the time of testing. These two tests index the degree of inter- and intrasentence information integration, respectively. Two findings indicated that integration affected free recall of an ambiguous passage. First, when the degree of integration of the passage's propositions was controlled, free recall of the passage was no different for subjects who did or did not know the passage's title at encoding. Second, inducing subjects to comprehend the passage's sentences individually, without relating them to one another, reduced free recall of the passage.     

The effects of self-exposure instructions on agoraphobic outpatients

Nineteen agoraphobic outpatients were randomly assigned to four sessions of either (1) Exposure: planning and discussion of exposure homework tasks requiring patients to enter and remain in phobic situations hitherto avoided; or (2) Control: discussion of marital, family and social difficulties and strategies for dealing with these.A small but significant effect was found at post-test and at one month follow-up in favour of the exposure condition. It is suggested that this variable should be controlled in future relevant experiments and is worth including as an inexpensive expedient of active treatment of phobias.     

Skill-set,success outcome,and mania as determinants of the illusion of control

The illusion of control, the tendency for individuals to approach chance tasks with skill-appropriate strategies, was studied. Subjects premeasured on a mania scale were classified as either high (HM) or low (LM) in mania. In the first phase of the study, HM and LM subjects performed 30 trials on either a skill (verbal associates) or chance (coin-toss) task and were given either 20, 50, or 80% success feedback. After Task 1 was completed, subjects filled out an attribution questionnaire. In the final phase of the study, subjects anticipated 30 more trials either on a skill or chance task. Subjects' predicted successes were measured. It was hypothesized that predicted successes on anticipated skill and chance tasks would be affected more by outcomes on a previous skill task than by outcomes on a previous chance task. The results for the anticipated skill task directly supported the hypothesis. On the anticipated chance task, the hypothesis was confirmed for HM subjects only. The results are discussed in terms of how previous skill experiences may induce a set to control ungovernable situations for individuals with manic reactions.     

History of psychotherapy in Russia and the Soviet Union]

Previously, articles on and contributions to the history of psychotherapy proceeded on the assumption that the most essential sources were to be found in Anglo-Saxon and German literature. Developments in other civilizations were usually treated as undeserving of consideration. It is important to note that a large amount of specialized literature on psychotherapy has been published in the Soviet Union, and this shows that a great importance is attached in that country to the treatment of nervous and mental disorders by psychological methods. A review of the writings of S. S. Korsakov and V. M. Bekhterev shows that the essential principles of group psychotherapy had been recognized by those authors already in the late nineteenth and early twentieth centuries, respectively. Results achieved by Makarenko appear valuable in the light of what we know today. The method of "collective psychotherapy", which was first described by Libch, is discussed in detail. This method is being widely used in the Soviet Union. The concern of this paper is to describe developments which have not so far been covered in our literature, thus attempting to make an addition to psychotherapeutic activity in this country.     

Author Correction: Supervaluation-Style Truth Without Supervaluations

Journal of Philosophical Logic - The original version of the article unfortunately contained a mistake. In the Acknowledgments section of the original version of the article, the grant number of...