Misconduct in science: Controversy and progress

Conclusion It is clear that the concept of scientific misconduct continues to evolve. As always it is the goal of Science and Engineering Ethics to move the discussion forward, to encourage and facilitate discussion of the ethical issues and problems that practicing scientists and engineers encounter in the course of pursuing their professions. This collection of articles and commentaries provides a variety of perspectives that we expect will facilitate communication among and within the groups who must participate in this evolution. The opinions expressed herein are those of the author and do not necessarily reflect the policies of the Office of Research Integrity, the Department of Health and Human Services, or any other Federal agency.     

Uptake of Cardiac Screening and Genetic Testing Among Hypertrophic and Dilated Cardiomyopathy Families

Cardiomyopathy is a genetically and clinically heterogeneous, life threatening disease which affects people of all ages. Recent guidelines provide recommendations for cardiac screening and genetic testing in at-risk relatives, but the uptake and impact of these measures in the United States is unknown. This is a single institution retrospective study that characterizes the uptake of cardiac screening and genetic testing for relatives of a cohort of 57 probands with hypertrophic (HCM) and dilated cardiomyopathy (DCM) who underwent both clinical evaluation and genetic testing. Cardiac screening was indicated for 302 relatives. One hundred and seventy-three (57 %) completed cardiac screening. Forty of the 57 probands were mutation positive and genetic testing was indicated for 213 relatives. Eighty-four (39 %) completed genetic testing. The uptake of cardiac surveillance was greater than the uptake of genetic testing (p?<?0.0001) among relatives of mutation positive probands. Within the group of at-risk, asymptomatic relatives of probands, cardiac screening and genetic testing were positive in 25 % and 40 % of cases, respectively. These data demonstrate the important role and utility of cascade cardiac screening and genetic testing in the care of patients and families with HCM or DCM. The approach to cardiac screening and genetic testing should be family-specific and requires expertise in the genetics of cardiomyopathy.     

Developmental sequences in the age of onset of disruptive child behaviors

Retrospective and prospective reports of the onset of disruptive child behaviors were analyzed in a sample of clinic-referred boys. The younger boys (ages 7–9 years), compared with the older boys (ages 10–12 years), showed the highest level of disruptive behavior and, judging from mothers' reports, had the fastest progression of onsets from less serious to more serious problem behaviors. Despite some overlap, developmental sequences in problem behavior within the domains of hyperactivity/inattention, oppositional behavior, and conduct problems were similar across the two age groups. This was also the case for developmental sequences of overt or confrontive problem behaviors and covert or concealing conduct problems. Sequences of the onset of oppositional behavior and conduct problems were validated through prospective data, based on the information from mothers, teachers, and boys themselves. The implications of the findings are discussed for the formulation of developmental pathways of behavior and the analysis of causal factors.     

Functional communication training and noncontingent reinforcement in treatment of stereotypy

A 6‐year‐old boy with autism spectrum disorder engaged in automatically maintained stereotypy in the form of opening and closing doors. A functional analysis confirmed that he also emitted problem behavior that was maintained by access to stereotypy. We evaluated the separate and combined effects of functional communication training and arbitrary noncontingent reinforcement on both response classes. Results showed that the combination of functional communication training and noncontingent reinforcement was more effective at reducing stereotypy than either intervention on its own, although effects on problem behavior were unclear. These results suggest that combinations of interventions may be useful in the treatment of automatically maintained problem behavior.     

REVIEWS

Feminism and Addiction, Claudia Bepko (Ed.). New York.
Feminist Perspectives on Addictions, Nan Van Den Bergh (Ed.). New York.
Engendered Lives, Ellyn Kaschak. New York.
Seldom Seen, Rarely Heard: Women's Place in Psychology, Jams Bohan (Ed.).
Still Loved by the Sun: A Rape Survivor's Journal, Migael Scherer. New York.     

Misgendering and Its Moral Contestability

In this article, I consider the harms inflicted upon transgender persons through “misgendering,” that is, such deployments of gender terms that diminish transgender persons' self‐respect, limit the discursive resources at their disposal to define their own gender, and cause them microaggressive psychological harms. Such deployments are morally contestable, that is, they can be challenged on ethical or political grounds. Two characterizations of “woman” proposed in the feminist literature are critiqued from this perspective. When we consider what would happen to transgender women upon the broad implementation of these characterizations within transgender women's social context, we discover that they suffer from two defects: they either exclude at least some transgender women, or else they implicitly foster hierarchies among women, marginalizing transgender women in particular. In conclusion, I claim that the moral contestability of gender‐term deployments acts as a stimulus to regularly consider the provisionality and revisability of our deployments of the term “woman.”     

Borderline personality disorder features predict negative outcomes 2 years later

In a sample of 351 young adults, the authors assessed whether borderline personality disorder (BPD) features prospectively predicted negative outcomes (poorer academic achievement and social maladjustment) over the subsequent 2 years, over and above gender and both Axis I and Axis II psychopathology. Borderline traits were significantly related to these outcomes, with impulsivity and affective instability the most highly associated. The present findings suggest that the impulsivity and affective instability associated with BPD leads to impairment in relating well with others, in meeting social role obligations, and in academic or occupational achievement. Therefore, these may be especially important features to target in interventions for BPD.     

Temporal dynamics of anxiety-related attentional bias: is affective context a missing piece of the puzzle?

Previous research has demonstrated that anxious individuals attend to negative emotional information at the expense of other information. This is commonly referred to as attentional bias. The field has historically conceived of this process as relatively static; however, research by [Zvielli, A., Bernstein, A., &; Koster, E. H. W. (2014). Dynamics of attentional bias to threat in anxious adults: Bias towards and/or away? PLoS ONE, 9(8), e104025; Zvielli, A., Bernstein, A., &; Koster, E. H. W. (2015). Temporal dynamics of attentional bias. Clinical Psychological Science, 3(5), 772–788.], and others, challenges this assumption by demonstrating considerable temporal variability in attentional bias amongst anxious individuals. Still, the mechanisms driving these temporal dynamics are less well known. Using a modified dot-probe task, the present study examined the impact of two relevant contextual variables- affective valence and trial repetition. Affective context was instantiated by the presentation of negative versus neutral pictures before each trial, while repetition context was achieved via the presentation of the valenced pictures in either a blocked- or mixed-trial design. Results indicate that individuals with higher trait-anxiety levels were significantly more influenced by blocked presentations of negative affective information, leading to greater temporal fluctuations in attentional bias. Furthermore, our findings provide additional evidence that attentional bias is best conceptualised as dynamic and variable, and that an individual’s affective experience is one factor that regulates attentional bias dynamics. Implications relating to theoretical and methodological factors are discussed.     

Constructing Difference: Lego® Set Narratives Promote Stereotypic Gender Roles and Play

LEGO® construction sets are a staple in many children’s lives. Given worldwide distribution, generations of children have grown up playing with these brightly colored, interlocking plastic bricks. Historically marketed to all children, the LEGO® Group has begun targeting male and female consumers differentially with the introduction of product lines such as LEGO® City and LEGO® Friends. Although the packaging, marketing, brick colors, and characters have changed, little is known about whether these product series encourage differences in the way boys and girls play. This content analysis compared the play narratives of sets marketed to boys (LEGO® City) and girls (LEGO® Friends). Our analysis found distinct gendered messages that encourage boys to enact various skilled professions, heroism, and expertise, whereas girls are encouraged to focus on having hobbies, being domestic, caring for others, socializing, being amateurs, and appreciating and striving for beauty. Although LEGO® City and Friends sets offer opportunities for construction, they also promote stereotyped gender roles for enacting femininity and masculinity in play. Parents, educators, and practitioners often focus on the educational affordances of LEGO® construction. We recommend that they also consider the other lessons, both explicit and implicit, being taught through gender-specific LEGO® sets.