“Bridge to the Literature”? Third-Party Genetic Interpretation Tools and the Views of Tool Developers

Patients and health care consumers can obtain access to their “raw,” or uninterpreted, genetic data from direct-to-consumer genetic testing companies, researchers, or providers and pursue self-directed analysis via third-party interpretation tools. Yet relatively little is known about the nature of currently available interpretation tools or the motivations of tool developers. We conducted a structured content analysis of 23 third-party interpretation tool websites and supporting information, tracking features such as types of information returned, modes of generating and presenting that information, and privacy and security measures. We additionally conducted qualitative interviews with a subset of 10 tool developers. A majority of tools (16 of 23, or 70%) offer some type of health or wellness-related information, often extracted from publicly available variant annotation databases. Half of those interviewed characterized their activities as “bridging” users to the scientific literature rather than interpretation, for which they gave a variety of scientific, ethical, and regulatory justifications. The scale, heterogeneity, and complexity of information available from third-party interpretation are unprecedented. While developers aim to enlighten and empower tool users, interpretation-free “bridging” to rapidly evolving databases may instead impose burdens on genetic counselors and other health care providers asked to provide further contextualization and explanation.     

Virtual Reality and Cognitive-Behavioral Therapy for Driving Anxiety and Aggression in Veterans: A Pilot Study

Within the U.S. military, motor vehicle accidents (MVAs) are the leading cause of preventable morbidity and mortality. Prior combat exposure and anxiety symptoms are associated with risky and aggressive driving, which is responsible for over half of MVA fatalities. Therefore, interventions are needed to reduce driving anxiety and aggression in veterans in order to mitigate the public health impact of MVAs. Virtual reality exposure therapy (VRET) offers safe, controlled exposure to distressing stimuli. The current study piloted a novel virtual reality and cognitive behavioral intervention (VRET + CBT) for veterans that integrated both anxiety and anger management components. Virtual reality driving scenarios were delivered in a driving simulator and tailored for the military population. Six previously deployed veterans completed eight intervention sessions, as well as pre/post, one month follow-up and six to nine month follow-up assessments. Repeated measures ANOVAs demonstrated significant decline and large effect sizes for PTSD symptoms, driving phobia, hyperarousal in driving situations, anxiety/anger-related thoughts and behaviors, and risky driving. Hyperarousal in driving situations declined by 69%, aggressive driving declined by 29%, and risky driving declined by 21%. Treatment gains were maintained at follow-up. Recruitment, retention, immersion, simulator sickness scores, and qualitative feedback demonstrated feasibility of the intervention. Implications for future research and adaptation are discussed.     

Impulsive choice and pre‐exposure to delays: iv. effects of delay‐ and immediacy‐exposure training relative to maturational changes in impulsivity

Impulsive choice describes preference for smaller, sooner rewards over larger, later rewards. Excessive delay discounting (i.e., rapid devaluation of delayed rewards) underlies some impulsive choices, and is observed in many maladaptive behaviors (e.g., substance abuse, gambling). Interventions designed to reduce delay discounting may provide therapeutic gains. One such intervention provides rats with extended training with delayed reinforcers. When compared to a group given extended training with immediate reinforcers, delay‐exposed rats make significantly fewer impulsive choices. To what extent is this difference due to delay‐exposure training shifting preference toward self‐control or immediacy‐exposure training (the putative control group) shifting preference toward impulsivity? The current study compared the effects of delay‐ and immediacy‐exposure training to a no‐training control group and evaluated within‐subject changes in impulsive choice across 51 male Wistar rats. Delay‐exposed rats made significantly fewer impulsive choices than immediacy‐exposed and control rats. Between‐group differences in impulsive choice were not observed in the latter two groups. While delay‐exposed rats showed large, significant pre‐ to posttraining reductions in impulsive choice, immediacy‐exposed and control rats showed small reductions in impulsive choice. These results suggest that extended training with delayed reinforcers reduces impulsive choice, and that extended training with immediate reinforcers does not increase impulsive choice.     

Knowledge of sex-role stereotypes in children aged 3 to 5

When do children begin acquiring adult sex-role stereotypes? This study examined the sex-stereotypic knowledge of four groups of young children: 3.0–3.5, 3.5–4.0, 4.0–4.5, and 4.5–5.0 years old. To assess the development of their knowledge, the same children were retested six months later. Evidence of sex-stereotyping appeared at 3.5 years and increased both across the different age groups and within the same children as they aged. The children's knowledge encompassed both feminine and masculine traits, and was related to general intellectual development. These results are interpreted as supporting cognitive-developmental theories that children learn sex-role stereotypes as structural rules for organizing and understanding behaviors present in their social environment.Thanks are due to Diane Bulow, Grace Horsman, Barbara Kutner, Joan Strutts, and the other teachers for aiding our access to children enrolled in their centers. Moira Davidson, Beth Kaplan, Keith Miller, Suzanna Nam, Dan Birecree, Sara Corse, Jim Gilbert, Jean Merenda, Anna Steiner, and Steve Tannenbaum served graciously as testers.     

Just banter? Friendship,teasing and experimental aggression in adolescent peer networks

Aggressive behaviour serves many useful social functions, yet can also have damaging consequences. In line with evidence showing adolescent development in social cognitive abilities, we hypothesized that the use of aggression would become more sophisticated with age. We investigated adolescent aggression towards peers using an experimental, hypothetical aggression paradigm, the hot sauce paradigm, in a school‐based social network setting. Participants (N = 162 aged 11–17, 98 male) indicated which strength of imaginary hot sauce they would allocate to each of their classmates. A Social Network Questionnaire quantified participants’ perceived dyadic social tie strength with each classmate, and the incidence of mutual or unilateral dyadic real‐world aggression (e.g. teasing). Participants allocated weaker hot sauce to peers with whom they reported strong, positive social ties and an absence of self‐reported unilateral real‐world aggression. With increasing cross‐sectional age, there was a decrease in the impact of social tie strength and an increase in the extent to which hot sauce allocation was predicted by self‐reported mutual real‐world aggression. This pattern of findings is consistent with young (vs. late) adolescent use of experimental, hypothetical Hot Sauce aggression to reflect real‐world animosity, while late adolescents’ behaviour is more subtle. These findings extend our understanding of the dyadic social context of adolescent aggressive behaviour using a novel experimental aggression paradigm.     

Long Term Child-Centered Play Therapy Effects on Academic Achievement with Normal Functioning Children

This follow up study with 23 normal functioning 1st graders examined the long-term effectiveness of Child-Centered Play Therapy (CCPT) on academic achievement. Through the use of a one-way repeated measures analysis of variance, researchers examined the use of CCPT from pre-intervention to mid-intervention (16 sessions) to post-intervention (26 sessions). Results indicated that children who participated in 26 sessions of CCPT demonstrated statistically significant improvement on the Early Achievement Composite as measured on the Young Children’s Achievement Test (YCAT), along with increases in the Reading, Mathematics, and Spoken Language subscales. Participants showed statistically consistent improvement in academic scores of the full duration of the study. Overall, the findings imply that CCPT as a long term method can support academic achievement in the school system with normal functioning 1st grade students. The outcome suggests long term CCPT is an intervention for elementary/primary school counselors to use with children who have emotional or academic needs. The findings open the door for school counselors or outside professionals to use play therapy with children in the school system as a way of providing academic support and thereby promoting the field of play therapy in the school system.     

Testing the generality of the zoom-lens model: Evidence for visual-pathway specific effects of attended-region size on perception

There are volumes of information available to process in visual scenes. Visual spatial attention is a critically important selection mechanism that prevents these volumes from overwhelming our visual system’s limited-capacity processing resources. We were interested in understanding the effect of the size of the attended area on visual perception. The prevailing model of attended-region size across cognition, perception, and neuroscience is the zoom-lens model. This model stipulates that the magnitude of perceptual processing enhancement is inversely related to the size of the attended region, such that a narrow attended-region facilitates greater perceptual enhancement than a wider region. Yet visual processing is subserved by two major visual pathways (magnocellular and parvocellular) that operate with a degree of independence in early visual processing and encode contrasting visual information. Historically, testing of the zoom-lens has used measures of spatial acuity ideally suited to parvocellular processing. This, therefore, raises questions about the generality of the zoom-lens model to different aspects of visual perception. We found that while a narrow attended-region facilitated spatial acuity and the perception of high spatial frequency targets, it had no impact on either temporal acuity or the perception of low spatial frequency targets. This pattern also held up when targets were not presented centrally. This supports the notion that visual attended-region size has dissociable effects on magnocellular versus parvocellular mediated visual processing.