Contracting, prompting, and reinforcing substance use disorder continuing care: a randomized clinical trial.

Although continuing care is strongly related to positive treatment outcomes for substance use disorder (SUD), participation rates are low and few effective interventions are available. In a randomized clinical trial with 150 participants (97% men), 75 graduates of a residential Veterans Affairs Medical Center SUD program who received an aftercare contract, attendance prompts, and reinforcers (CPR) were compared to 75 graduates who received standard treatment (STX). Among CPR participants, 55% completed at least 3 months of aftercare, compared to 36% in STX. Similarly, CPR participants remained in treatment longer than those in STX (5.5 vs. 4.4 months). Additionally, CPR participants were more likely to be abstinent compared to STX (57% vs. 37%) after 1 year. The CPR intervention offers a practical means to improve adherence among individuals in SUD treatment.     

So that's why I don't remember: normalizing forgetting of childhood events influences false autobiographical beliefs but not memories

We investigated changes in autobiographical belief and memory ratings for childhood events, after informing individuals that forgetting childhood events is common. Participants received false prevalence information (indicating that a particular childhood event occurred frequently in the population) plus a rationale normalizing the forgetting of childhood events; false prevalence information alone; or no manipulation, for one (Study 1) or two (Study 2) unlikely childhood events. Results demonstrated that combining prevalence information and the "forgetting rationale" substantially influenced autobiographical belief ratings, whereas prevalence information alone had no impact (Study 1) or a significantly lesser impact (Study 2) on belief ratings. Prevalence information consistently impacted plausibility ratings. No changes in memory ratings were observed. These results provide further support for a nested relationship between judgements of plausibility, belief, and memory in evaluating the occurrence of autobiographical events. Furthermore, the results suggest that some purported false memory phenomena may instead reflect the development of autobiographical false beliefs in the absence of memory.     

Are we there yet? A review of gender comparisons in three behavioral journals through the 20th century

Despite overwhelming evidence that gender plays a significant role in the course of numerous psychological disorders, researchers have historically neglected to address gender similarities and differences in their research. Previous reviews of the psychological literature have indicated that personality, psychotherapy, and behavioral psychology journals have published few studies that focus on gender comparisons. The current review examined published articles in three prominent behavioral psychology journals—Behavior Therapy, Behavior Modification, and Behaviour Research and Therapy—from their inception through 2001. Raters coded each article (N = 4,635) for gender content in the title or abstract, analyses of gender differences, and discussion of gender. Overall, very few articles focused on gender content in the title, abstract, or discussion or analyzed data by gender. Implications of these results and suggestions for enhancing attention to gender comparisons are discussed.     

Attitudes Toward Fragile X Mutation Carrier Testing from Women Identified in a General Population Survey

Fragile X syndrome is primarily due to a CGG repeat expansion found in the FMR1 X-linked gene. In a previous study, we conducted focus groups with women to assess their attitudes towards fragile X carrier screening. In this follow-up study, we conducted in-depth interviews of general population reproductive-age women who were identified as carriers. We explored their attitudes toward testing for carrier status of the fragile X mutation. These women underwent screening primarily to participate in a research project rather than in search of a diagnosis for specific symptoms. As such, these women were wholly unprepared for positive carrier results. Their responses about their results and carrier screening, in many cases, were being worked out over the course of the interview itself. The most salient finding of this work is the apparent lack of relevance of carrier status to these women. Many expressed that although the information could be relevant in the future, it is not relevant at this stage of their lives in terms of family planning (either with respect to having unaffected offspring or to premature ovarian failure) and personal relationships. Although issues of abortion seemed prominent in the focus groups, we found that carrier status did not have an apparent effect on women’s attitudes about termination. We hypothesize this may be related to the fact that women had not processed their new carrier status and had not related it to previously-formed personal opinions. The findings of this work have significant implications for genetic counseling and population screening. Genetic counselors should be mindful that general population women may not recognize the immediate importance of their carrier status even when literature is provided and discussed prior to providing a sample. As part of comprehensive genetic counseling, counselors should identify the reproductive life stage of the woman receiving the new information and help her identify when this information would be more meaningful in her life. Counselors can assist in setting up a personalized road map with specific types of services that will be more applicable to the woman as her carrier status becomes more relevant.     

Enriching the environment of alphaCaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP

alphaCaMKII(T286A) mutant mice lack long-term potentiation (LTP) in the hippocampal CA1 region and are impaired in spatial learning. In situ hybridization confirms that the mutant mice show the same developmental expression of alphaCaMKII as their wild-type littermates. A simple hypothesis would suggest that if LTP is a substrate for learning, then enriching the environment should cause learning-dependent changes in wild-type mice that have LTP. Such changes would not be seen in LTP-deficient alphaCaMKII(T286A) mutants. Excitatory synaptic currents in CA1 neurons, recorded with patch clamp in brain slices, revealed that enrichment induces an increase in glutamate release probability and a decreased miniature current amplitude. Confocal microscopy also showed dendritic spine density to be reduced. However, contrary to the hypothesis above, these enrichment-induced changes occur only in the mutant mice and are not detectable in wild-type littermates. We suggest that enrichment induces alphaCaMKII-independent changes in both wild-type and mutant mice. Such changes may be subsequently reversed in wild-type animals via alphaCaMKII-dependent mechanisms, such as LTP. Reversal of plasticity has long been hypothesized to be essential for the hippocampus to maintain its role in memory processing. The inability to reverse plasticity in alphaCaMKII(T286A) mutant mice would then result in impairment of spatial learning.     

Impairments in trace EB conditioning by knife-cut lesions to the fornix in rabbits: reversal by galantamine

Previous work in our laboratory demonstrated that galantamine, a cholinesterase inhibitor and weak cholinergic agonist, facilitated classical trace eyeblink conditioning in healthy, young rabbits [Simon, B. B., Knuckley, B., & Powell, D. A. (2004). Galantamine facilitates acquisition of a trace-conditioned eyeblink response in healthy, young rabbits. Learning & Memory, 11(1), 116-122.]. The current study investigated the effects of galantamine (0.0 or 3.0mg/kg) in rabbits sustaining knife-cut lesions to the fimbria-fornix, a major projection pathway connecting the hippocampus to cortical and subcortical brain structures involved in the formation of long-term memories. Two experiments were conducted. Experiment one assessed the effects of knife-cut lesions to the fornix or sham surgeries on trace eyeblink (EB) conditioning. Results indicate that fornix lesions significantly retarded EB conditioning when trace parameters were employed. Experiment 2 assessed whether treatment with galantamine would reverse the deficits caused by fornix damage. Results indicate that 3.0mg/kg GAL reversed trace EB conditioning deficits in animals with fornix knife-cut lesions. These findings suggest that galantamine may provide benefit in the reversal of cognitive dysfunction following certain types of brain damage, especially damage involving hippocampal structures.     

Norm-Narrowing and Self- and Other-Perceived Aggression in Early-Adolescent Same-Sex and Mixed-Sex Cliques

We examined the relations between group context and self- and other-perceptions of aggressive behavior in an ethnically-diverse sample of 168 male and female grade 7 adolescents. We used self- and peer-reports of aggression in high- and average-aggressive mixed-sex and same-sex cliques to examine whether group members would assimilate their self-report of aggression to the aggression report of their peers by way of perceived homophily or, conversely, engage in contrast and see their level of aggression as comparatively low in the face of high-aggression peers. Among boys in mixed-sex groups, comparison with highly-aggressive others resulted in a self-perception of lower levels of aggression than those perceived by their peers. Conversely, girls in mixed-sex groups reported their own levels of aggression to be higher than those perceived by their peers. We interpret these findings in terms of the notion of “norm narrowing”: rather than being set by the larger social environment, such as the school, norms are more narrowly determined within one's immediate peer group.     

“Am I Still a Virgin?”: What Counts as Sex in 20 years of <Emphasis Type="Italic">Seventeen</Emphasis>

In this paper, I analyze what counts as sex using a qualitative content analysis of the sexuality and health advice columns in Seventeen from 1982 to 2001. These columns are a useful source for identifying adolescent sexual norms including what counts as sex. Previous sex research often assumed that sex meant penile–vaginal intercourse and was the cause of virginity loss. Thus, I use virginity-related key terms (e.g., virgin, sex) to identify the sexuality and health advice columns pertinent to this project. These columns illustrate how multiple sexual acts can cause virginity loss; however, Seventeen remains ambiguous in its discussion of what counts as sex. Letter writers are concerned with what sexual acts they can participate in and still remain virgins and what act defines virginity loss. My analysis reveals that the columns reinforce heteronormativity by telling readers virginity is lost only through penile–vaginal intercourse. Additionally, Seventeen supports the sexual double standard by placing the responsibility of sexual behavior solely on female adolescents rather than on them and their partners.     

Debiasing of Pessimistic Judgments Associated with Anxiety: A Test of the Availability Heuristic

This investigation directly tested the Consider-An-Alternative debiasing procedure and the reduction of pessimistic threat-related judgments associated with anxiety. Two separate generation interventions were included to test the availability heuristic as a possible explanation of the debiasing effect. Participants were randomly assigned to one of three interventions and probability estimates of future threat-related events were completed in a repeated measures experimental design. Level of trait anxiety was measured to assign participants to “normal” and highly anxious groups. The data were analyzed in a 3 × 2 × 2 mixed factorial repeated measures ANOVA. The results found that only the short debiasing intervention showed a significant reduction of pessimistic judgments in comparison to the control group. The results were interpreted as supporting the availability heuristic as an explanation of the debiasing effect. Further analysis also suggested that the content of recall may be as important to the debiasing effect as ease of recall.     

Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder

Classical fear-conditioning is central to many etiologic accounts of panic disorder (PD), but few lab-based conditioning studies in PD have been conducted. One conditioning perspective proposes associative-learning deficits characterized by deficient safety learning among PD patients. The current study of PD assesses acquisition and retention of discriminative aversive conditioning using a fear-potentiated startle paradigm. This paradigm was chosen for its specific capacity to independently assess safety- and danger learning in the service of characterizing putative anomalies in each type of learning among those with PD. Though no group difference in fear-potentiated startle was found at retention, acquisition results demonstrate impaired discriminative learning among PD patients as indexed by measures of conditioned startle-potentiation to learned safety and danger cues. Importantly, this discrimination deficit was driven by enhanced startle-potentiation to the learned safety cue rather than aberrant reactivity to the danger cue. Consistent with this finding, PD patients relative to healthy individuals reported higher expectancies of dangerous outcomes in the presence of the safety cue, but equal danger expectancies during exposure to the danger cue. Such results link PD to impaired discrimination learning, reflecting elevated fear responding to learned safety cues.