Are we there yet? A review of gender comparisons in three behavioral journals through the 20th century

Despite overwhelming evidence that gender plays a significant role in the course of numerous psychological disorders, researchers have historically neglected to address gender similarities and differences in their research. Previous reviews of the psychological literature have indicated that personality, psychotherapy, and behavioral psychology journals have published few studies that focus on gender comparisons. The current review examined published articles in three prominent behavioral psychology journals—Behavior Therapy, Behavior Modification, and Behaviour Research and Therapy—from their inception through 2001. Raters coded each article (N = 4,635) for gender content in the title or abstract, analyses of gender differences, and discussion of gender. Overall, very few articles focused on gender content in the title, abstract, or discussion or analyzed data by gender. Implications of these results and suggestions for enhancing attention to gender comparisons are discussed.     

Attitudes Toward Fragile X Mutation Carrier Testing from Women Identified in a General Population Survey

Fragile X syndrome is primarily due to a CGG repeat expansion found in the FMR1 X-linked gene. In a previous study, we conducted focus groups with women to assess their attitudes towards fragile X carrier screening. In this follow-up study, we conducted in-depth interviews of general population reproductive-age women who were identified as carriers. We explored their attitudes toward testing for carrier status of the fragile X mutation. These women underwent screening primarily to participate in a research project rather than in search of a diagnosis for specific symptoms. As such, these women were wholly unprepared for positive carrier results. Their responses about their results and carrier screening, in many cases, were being worked out over the course of the interview itself. The most salient finding of this work is the apparent lack of relevance of carrier status to these women. Many expressed that although the information could be relevant in the future, it is not relevant at this stage of their lives in terms of family planning (either with respect to having unaffected offspring or to premature ovarian failure) and personal relationships. Although issues of abortion seemed prominent in the focus groups, we found that carrier status did not have an apparent effect on women’s attitudes about termination. We hypothesize this may be related to the fact that women had not processed their new carrier status and had not related it to previously-formed personal opinions. The findings of this work have significant implications for genetic counseling and population screening. Genetic counselors should be mindful that general population women may not recognize the immediate importance of their carrier status even when literature is provided and discussed prior to providing a sample. As part of comprehensive genetic counseling, counselors should identify the reproductive life stage of the woman receiving the new information and help her identify when this information would be more meaningful in her life. Counselors can assist in setting up a personalized road map with specific types of services that will be more applicable to the woman as her carrier status becomes more relevant.     

Enriching the environment of alphaCaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP

alphaCaMKII(T286A) mutant mice lack long-term potentiation (LTP) in the hippocampal CA1 region and are impaired in spatial learning. In situ hybridization confirms that the mutant mice show the same developmental expression of alphaCaMKII as their wild-type littermates. A simple hypothesis would suggest that if LTP is a substrate for learning, then enriching the environment should cause learning-dependent changes in wild-type mice that have LTP. Such changes would not be seen in LTP-deficient alphaCaMKII(T286A) mutants. Excitatory synaptic currents in CA1 neurons, recorded with patch clamp in brain slices, revealed that enrichment induces an increase in glutamate release probability and a decreased miniature current amplitude. Confocal microscopy also showed dendritic spine density to be reduced. However, contrary to the hypothesis above, these enrichment-induced changes occur only in the mutant mice and are not detectable in wild-type littermates. We suggest that enrichment induces alphaCaMKII-independent changes in both wild-type and mutant mice. Such changes may be subsequently reversed in wild-type animals via alphaCaMKII-dependent mechanisms, such as LTP. Reversal of plasticity has long been hypothesized to be essential for the hippocampus to maintain its role in memory processing. The inability to reverse plasticity in alphaCaMKII(T286A) mutant mice would then result in impairment of spatial learning.     

Impairments in trace EB conditioning by knife-cut lesions to the fornix in rabbits: reversal by galantamine

Previous work in our laboratory demonstrated that galantamine, a cholinesterase inhibitor and weak cholinergic agonist, facilitated classical trace eyeblink conditioning in healthy, young rabbits [Simon, B. B., Knuckley, B., & Powell, D. A. (2004). Galantamine facilitates acquisition of a trace-conditioned eyeblink response in healthy, young rabbits. Learning & Memory, 11(1), 116-122.]. The current study investigated the effects of galantamine (0.0 or 3.0mg/kg) in rabbits sustaining knife-cut lesions to the fimbria-fornix, a major projection pathway connecting the hippocampus to cortical and subcortical brain structures involved in the formation of long-term memories. Two experiments were conducted. Experiment one assessed the effects of knife-cut lesions to the fornix or sham surgeries on trace eyeblink (EB) conditioning. Results indicate that fornix lesions significantly retarded EB conditioning when trace parameters were employed. Experiment 2 assessed whether treatment with galantamine would reverse the deficits caused by fornix damage. Results indicate that 3.0mg/kg GAL reversed trace EB conditioning deficits in animals with fornix knife-cut lesions. These findings suggest that galantamine may provide benefit in the reversal of cognitive dysfunction following certain types of brain damage, especially damage involving hippocampal structures.     

“Am I Still a Virgin?”: What Counts as Sex in 20 years of <Emphasis Type="Italic">Seventeen</Emphasis>

In this paper, I analyze what counts as sex using a qualitative content analysis of the sexuality and health advice columns in Seventeen from 1982 to 2001. These columns are a useful source for identifying adolescent sexual norms including what counts as sex. Previous sex research often assumed that sex meant penile–vaginal intercourse and was the cause of virginity loss. Thus, I use virginity-related key terms (e.g., virgin, sex) to identify the sexuality and health advice columns pertinent to this project. These columns illustrate how multiple sexual acts can cause virginity loss; however, Seventeen remains ambiguous in its discussion of what counts as sex. Letter writers are concerned with what sexual acts they can participate in and still remain virgins and what act defines virginity loss. My analysis reveals that the columns reinforce heteronormativity by telling readers virginity is lost only through penile–vaginal intercourse. Additionally, Seventeen supports the sexual double standard by placing the responsibility of sexual behavior solely on female adolescents rather than on them and their partners.     

Debiasing of Pessimistic Judgments Associated with Anxiety: A Test of the Availability Heuristic

This investigation directly tested the Consider-An-Alternative debiasing procedure and the reduction of pessimistic threat-related judgments associated with anxiety. Two separate generation interventions were included to test the availability heuristic as a possible explanation of the debiasing effect. Participants were randomly assigned to one of three interventions and probability estimates of future threat-related events were completed in a repeated measures experimental design. Level of trait anxiety was measured to assign participants to “normal” and highly anxious groups. The data were analyzed in a 3 × 2 × 2 mixed factorial repeated measures ANOVA. The results found that only the short debiasing intervention showed a significant reduction of pessimistic judgments in comparison to the control group. The results were interpreted as supporting the availability heuristic as an explanation of the debiasing effect. Further analysis also suggested that the content of recall may be as important to the debiasing effect as ease of recall.     

Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder

Classical fear-conditioning is central to many etiologic accounts of panic disorder (PD), but few lab-based conditioning studies in PD have been conducted. One conditioning perspective proposes associative-learning deficits characterized by deficient safety learning among PD patients. The current study of PD assesses acquisition and retention of discriminative aversive conditioning using a fear-potentiated startle paradigm. This paradigm was chosen for its specific capacity to independently assess safety- and danger learning in the service of characterizing putative anomalies in each type of learning among those with PD. Though no group difference in fear-potentiated startle was found at retention, acquisition results demonstrate impaired discriminative learning among PD patients as indexed by measures of conditioned startle-potentiation to learned safety and danger cues. Importantly, this discrimination deficit was driven by enhanced startle-potentiation to the learned safety cue rather than aberrant reactivity to the danger cue. Consistent with this finding, PD patients relative to healthy individuals reported higher expectancies of dangerous outcomes in the presence of the safety cue, but equal danger expectancies during exposure to the danger cue. Such results link PD to impaired discrimination learning, reflecting elevated fear responding to learned safety cues.     

The Role of Depression, Shame-Proneness, and Guilt-Proneness in Predicting Criticism of Relatives Towards People With Bipolar Disorder

Expressed emotion (EE) has been associated with poor patient outcomes in many different psychiatric disorders. Given its robust association with relapse, EE has become a major target of family psychoeducational interventions. Most psychoeducational interventions to date have failed to change EE levels among families of those with bipolar disorder. Better intervention strategies, then, may depend on an increased understanding of the predictors of EE. Although EE has traditionally included many facets, criticism appears to be the most robust predictor of outcome within bipolar disorder. The present study tested three primary predictors of criticism among family members of people with bipolar disorder: shame-proneness, guilt-proneness, and depression. Depressive symptoms were significantly associated with EE. Discussion focuses on limitations and implications of the study and suggestions for future research.     

Loneliness,Interpersonal Distrust,and Alexithymia in University Students1

Loneliness has been linked to emotional knowledge and interpersonal distrust, but it is unknown whether it is mediated or moderated by these variables. Using self‐report measures, the relationship between loneliness, interpersonal distrust, and alexithymia was investigated in undergraduate students (N = 224). Analyses showed a direct relationship between alexithymia and social, family, and romantic loneliness. We also found that interpersonal distrust partly mediates this relationship, and that alexithymia and interpersonal distrust interacted to predict social and family loneliness. These findings suggest that links between the different facets of alexithymia, interpersonal distrust, and loneliness are complex and multifaceted, and they are discussed with regard to interventions for young adults.     

Early-Onset Bipolar Spectrum Disorders: Diagnostic Issues

Since the mid 1990s, early-onset bipolar spectrum disorders (BPSDs) have received increased attention in both the popular press and scholarly press. Rates of diagnosis of BPSD in children and adolescents have increased in inpatient, outpatient, and primary care settings. BPSDs remain difficult to diagnose, particularly in youth. The current diagnostic system makes few modifications to accommodate children and adolescents. Researchers in this area have developed specific BPSD definitions that affect the generalizability of their findings to all youth with BPSD. Despite knowledge gains from the research, BPSDs are still difficult to diagnose because clinicians must: (1) consider the impact of the child’s developmental level on symptom presentation (e.g., normative behavior prevalence, environmental limitations on youth behavior, pubertal status, irritability, symptom duration); (2) weigh associated impairment and course of illness (e.g., neurocognitive functioning, failing to meet full DSM criteria, future impairment); and (3) make decisions about appropriate assessment (differentiating BPSD from medical illnesses, medications, drug use, or other psychiatric diagnoses that might better account for symptoms; comorbid disorders; informant characteristics and assessment measures to use). Research findings concerning these challenges and relevant recommendations are offered. Areas for further research to guide clinicians’ assessment of children with early-onset BPSD are highlighted. Principal Investigators and Coinvestigators of Longitudinal Assessment of Manic Symptoms (LAMS) Group are listed in Appendix.