Anandamide and memory in CD1 mice: effects of immobilization stress and of prior experience

Five sets of experiments were carried out with CD1 mice tested in a one-trial inhibitory avoidance task. In a first set, immediately posttraining administrations of the endogenous ligand for the cannabinoid CB1 receptor anandamide (arachidonylethanolamide) (3 or 6 mg/kg) dose-dependently impaired memory consolidation in mice. A lower dose (1.5 mg/kg) was ineffective. In a second set of experiments, which was carried out at the same time of the first set, preexposure of the animals to the testing apparatus decreased the effect of the drug, as compared with non-preexposed mice. In a third set of experiments, administration of anandamide (3 or 6 mg/kg) prior to the retention test did not affect the retention performance of mice given posttraining injections of either saline or anandamide. These findings indicate that the memory-impairing effects of posttraining administration of anandamide are not state-dependent. In the fourth and fifth series of experiments, carried out with non-preexposed mice, an otherwise ineffective immobilization stress (15 min) enhanced the memory-impairing effect of anandamide, and an otherwise ineffective dose of naltrexone (0.1 mg/kg) completely antagonized the effect. The results are discussed in terms of attenuation of emotionality, resulting in impaired retention, following anandamide administration, and of involvement of opioid system in the effect of this drug.     

Who owns the contour of a visual hole?

Holes are useful in the study of shape, contour curvature, and border ownership. Several authors have suggested that holes have figural or quasi-figural status. I discuss three criteria to test the evidence that holes behave more like figures than like ground: (i) holes perceived as such; (ii) similar performance for holes and figures; (iii) different performance for holes and other ground regions. Using these criteria, I review the literature and conclude that holes do not have figural status in relation to border ownership. I also argue that holes are ideal stimuli to study figure-ground organisation.     

Detection of change in shape and its relation to part structure

Using a change detection paradigm (Barenholtz, E., Cohen, E. H., Feldman, J., & Singh, M. (2003). Detection of change in shape: An advantage for concavities. Cognition, 89(1) 1-9), we measured sensitivity to the changes of shapes and in particular the difference between detecting a new convex or concave vertex. We conclude that concave vertices per se are not more salient, but changes in the sequence of convexities and concavities along a contour are salient. We argue that these changes are likely to signal a change in perceived part structure.     

Mixing costs in task shifting reflect sequential processing stages in a multicomponent task

We investigated the hypothesis that mixing costs intask shifting reflect th e sequential selection of task components (e.g., stimulus categories) during task execution. This proposition was supported by Hübner, Futterer, and Steinhauser (2001), who showed that the amount of mixing costsdepends on the number of mixed task components (e.g., stimulus level and judgment). However, their results could also be explained by a task set selection account, because task components and task sets were confounded. In Experiments 1 and 2, we compared conditions in which either the number of task sets varied and the number of mixed task components was constant or vice versa. Only the number of mixed task components was predictive for the mixing costs. In Experiment 3, we replicated the additivity of mixing costs from level a ndjudgment mixing. Our results suggest thatthe mixingcosts reflect a selection strategy in which interference is reduced in a stepwise manner.     

On attentional control as a source of residual shift costs: evidence from two-component task shifts

It is widely assumed that supervisory or attentional control plays a role only in the preparatory reconfiguration of the mental system in task shifting. The well-known fact that residual shift costs are still present even after extensive preparation is usually attributed to passive mechanisms such as cross talk. The authors question this view and suggest that attentional control is also responsible for residual shift costs. The authors hypothesize that, under shift conditions, tasks are executed in a controlled mode to guarantee reliable performance. Consequently, the control of 2 task components should require more resources than the control of only 1. A series of 4 experiments with 2-component tasks was conducted to test this hypothesis. As expected, more residual shift costs were observed when 2 components rather than 1 varied across trials. Interference effects and sequential effects could not account for these results.     

Exploration and learning in capuchin monkeys (Sapajus spp.): the role of action–outcome contingencies

Animals have a strong propensity to explore the environment. Spontaneous exploration has a great biological significance since it allows animals to discover and learn the relation between specific behaviours and their consequences. The role of the contingency between action and outcome for learning has been mainly investigated in instrumental learning settings and much less in free exploration contexts. We tested 16 capuchin monkeys (Sapajus spp.) with a mechatronic platform that allowed complex modules to be manipulated and to produce different outcomes. Experimental subjects could manipulate the modules and discover the contingencies between their own specific actions and the outcomes produced (i.e., the opening and lighting of a box). By contrast, Control subjects could operate on the modules, but the outcomes experienced were those performed by their paired Experimental subjects (“yoked-control” paradigm). In the exploration phase, in which no food reward was present, Experimental subjects spent more time on the board and manipulated the modules more than Yoked subjects. Experimental subjects outperformed Yoked subjects in the following test phase, where success required recalling the effective action so to open the box, now baited with food. These findings demonstrate that the opportunity to experience action–outcome contingencies in the absence of extrinsic rewards promotes capuchins’ exploration and facilitates learning processes. Thus, this intrinsically motivated learning represents a powerful mechanism allowing the acquisition of skills and cognitive competence that the individual can later exploit for adaptive purposes.     

Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression

Although schizophrenia is associated with impairments in social cognition, the scope and neural correlates of these disturbances are largely unknown. In this study, we investigated whether schizophrenia patients show impaired functioning of the mirror neuron system (MNS), as indexed by electroencephalographic (EEG) mu (8–13 Hz) suppression, a hypothesized biomarker of MNS activity that is sensitive to the degree of social interaction depicted in visual stimuli. A total of 32 outpatients and 26 healthy controls completed an EEG paradigm that included six action observation or execution conditions that differed in their degrees of social interaction. Participants also completed a validated empathy questionnaire. Across both groups, we found a significant linear increase in mu suppression across the conditions involving greater levels of social engagement and interaction, but no significant group or interaction effects. Patients self-reported diminished empathic concern and perspective taking, which showed some moderate relations to mu suppression levels. Thus, the schizophrenia group showed generally intact modulation of MNS functioning at the electrophysiological level, despite self-reporting empathic disturbances. The disturbances commonly seen on self-report, performance, and neuroimaging measures of mentalizing in schizophrenia may largely reflect difficulties with higher-level inferential processes about others’ emotions, rather than a basic incapacity to share in these experiences.     

Young children attribute normativity to novel actions without pedagogy or normative language

Young children interpret some acts performed by adults as normatively governed, that is, as capable of being performed either rightly or wrongly. In previous experiments, children have made this interpretation when adults introduced them to novel acts with normative language (e.g. 'this is the way it goes'), along with pedagogical cues signaling culturally important information, and with social-pragmatic marking that this action is a token of a familiar type. In the current experiment, we exposed children to novel actions with no normative language, and we systematically varied pedagogical and social-pragmatic cues in an attempt to identify which of them, if either, would lead children to normative interpretations. We found that young 3-year-old children inferred normativity without any normative language and without any pedagogical cues. The only cue they used was adult social-pragmatic marking of the action as familiar, as if it were a token of a well-known type (as opposed to performing it, as if inventing it on the spot). These results suggest that - in the absence of explicit normative language - young children interpret adult actions as normatively governed based mainly on the intentionality (perhaps signaling conventionality) with which they are performed.