When does measurement error in covariates impact causal effect estimates? Analytic derivations of different scenarios and an empirical illustration

The average causal treatment effect (ATE) can be estimated from observational data based on covariate adjustment. Even if all confounding covariates are observed, they might not necessarily be reliably measured and may fail to obtain an unbiased ATE estimate. Instead of fallible covariates, the respective latent covariates can be used for covariate adjustment. But is it always necessary to use latent covariates? How well do analysis of covariance (ANCOVA) or propensity score (PS) methods estimate the ATE when latent covariates are used? We first analytically delineate the conditions under which latent instead of fallible covariates are necessary to obtain the ATE. Then we empirically examine the difference between ATE estimates when adjusting for fallible or latent covariates in an applied example. We discuss the issue of fallible covariates within a stochastic theory of causal effects and analyse data of a within-study comparison with recently developed ANCOVA and PS procedures that allow for latent covariates. We show that fallible covariates do not necessarily bias ATE estimates, but point out different scenarios in which adjusting for latent covariates is required. In our empirical application, we demonstrate how latent covariates can be incorporated for ATE estimation in ANCOVA and in PS analysis.     

Genetic Counseling and Screening of Consanguineous Couples and Their Offspring: Recommendations of the National Society of Genetic Counselors

The objective of this document is to provide recommendations for genetic counseling and screening for consanguineous couples (related as second cousins or closer) and their offspring with the goals of1. providing preconception reproductive options2. improving pregnancy outcome and identifying reproductive choices3. reducing morbidity and mortality in the 1st years of life, and4. respecting psychosocial and multicultural issues.The recommendations are the opinions of a multicenter working group (the Consanguinity Working Group (CWG)) with expertise in genetic counseling, medical genetics, biochemical genetics, genetic epidemiology, pediatrics, perinatology, and public health genetics, which was convened by the National Society of Genetic Counselors (NSGC). The consensus of the CWG and NSGC reviewers is that beyond a thorough medical family history with follow-up of significant findings, no additional preconception screening is recommended for consanguineous couples. Consanguineous couples should be offered similar genetic screening as suggested for any couple of their ethnic group. During pregnancy, consanguineous couples should be offered maternal–fetal serum marker screening and high-resolution fetal ultrasonography. Newborns should be screened for impaired hearing and detection of treatable inborn errors of metabolism. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. The professional judgment of a health care provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations.     

Psychopharmacologic strategies for the treatment of aggression in juveniles

Maladaptive aggression in youth is one of the most common and troublesome reasons for referrals to child psychiatrists. It has a complex relationship with psychopathology. There are several syndromes, which are primary disturbances of clustered maladaptive aggression, most notably oppositional defiant disorder and conduct disorder. However, problems with aggression also appear in a wide range of other disturbances, such as bipolar disorder, posttraumatic stress disorder, and mood disorders. Additionally, aggression is normative, serves an adaptive purpose and can be situationally induced. These complexities need to be carefully addressed before targeting maladaptive aggression psychopharmacologically. We summarize the literature on the psychopharmacology of maladaptive aggression in youth, focusing on disorders without cognitive impairment. We delineate the subtypes of aggression which are most likely to respond to medication (reactive-affective-defensive-impulsive in their acute and chronic form) and conclude with a discussion of specific medication strategies which are supported by controlled clinical trials and clinical experience.     

The remaining few: Christian Zionists making sense of a changed ecclesiastic landscape

Using a hermeneutical method, this study seeks to understand Christian Zionism as a meaningful practice in late modern Sweden. We visited four Christian Zionist conferences where we observed, analysed the sermons, and conducted interviews. The conferences are almost entirely attended by elderly people and the style is characterized by an old-time revivalist nostalgia. Results show that Israel is seen as a key to understanding a general conflict that the informants experience in late modern Swedish society and in relation to the majority church. Supporting Israel is intertwined with support for conservative values and theology and Israel becomes a nodal point that puts the greater conflict in a new perspective: identifying with Old Testament prophecies and God’s dealings with Israel gives hope and a sense of continuity to a revivalist movement that has become out of date. In Israel, Christian Zionists connect with both the past and the future, personally and as a movement.     

Test-Taker Reactions to the Selection Process: Effects of Outcome Favorability, Explanations, and Voice on Fairness Perceptions

This study examined the effects of providing an explanation and voice on fairness perceptions and reactions of test takers under favorable and unfavorable selection decisions. Participants took either a cognitive ability test or an overt integrity test in a simulated selection situation. Then, the voice manipulation was introduced. Participants were informed of the hiring decision with or without an explanation. Results showed that type of test had effects on procedural fairness perceptions such that these reactions were more positive when a cognitive ability test was used. The results of voice and explanation manipulations on fairness perceptions indicated that providing an explanation had a positive effect on perceptions but, surprisingly, face-validity perceptions were less favorable when participants had voice opportunity.     

From autonomy to heteronomy (and back): The enaction of social life

The term “social cognition” can be construed in different ways. On the one hand, it can refer to the cognitive faculties involved in social activities, defined simply as situations where two or more individuals interact. On this view, social systems would consist of interactions between autonomous individuals; these interactions form higher-level autonomous domains not reducible to individual actions. A contrasting, alternative view is based on a much stronger theoretical definition of a truly social domain, which is always defined by a set of structural norms; moreover, these social structures are not only a set of constraints, but actually constitute the possibility of enacting worlds that would just not exist without them. This view emphasises the heteronomy of individuals who abide by norms that are impersonal, culturally inherited and to a large extent independent of the individuals. Human beings are socialised through and through; consequently, all human cognition is social cognition. The article argues for this second position. Finally, it appears that fully blown autonomy actually requires heteronomy. It is the acceptance of the constraints of social structures that enables individuals to enter new realms of common meaningfulness. The emergence of social life marks a crucial step in the evolution of cognition; so that at some evolutionary point human cognition cannot but be social cognition.     

Proactive coping, gratitude, and posttraumatic stress disorder in college women

This study investigated relationships among proactive coping, positive emotions, and posttraumatic stress disorder (PTSD) symptom severity for 182 undergraduate women with trauma histories. Participants were administered the Life Events Checklist (LEC), PTSD Checklist, Proactive Coping Inventory, Proactive Attitude Scale, General Perceived Self-Efficacy Scale, and measures of posttrauma gratitude and emotional growth. An Exploratory Factor Analysis (EFA) with proactive coping, proactive attitude, and self-efficacy items indicated a one-factor solution. The proactive coping style factor and posttrauma gratitude were independently negatively associated with current PTSD symptom level, above and beyond the effects of trauma severity, trauma history, and time elapsed since the trauma. The implications of these results for future research and understanding of the development of PTSD and its treatment are discussed.     

Mental Health Professionals' Perceptions of Women's Experiences of Family Violence

This study explored perceptions of 92 mental health professionals regarding violent families. They were asked to answer the questions on the Family Environment Scale as they thought women who lived in homes where they and their children were physically and/or psychologically abused would respond. Their scores were compared to those of 28 mothers in battered women's shelters. They differed significantly in their perceptions of violent family dynamics with regard to levels of cohesion, expressiveness, independence, intellectual-cultural orientation, active-recreational emphasis, and moral-religious emphasis. They believed the women to have lower levels on these constructs than the women actually reported. Implications suggest that mental health professionals could be more aware of the dynamics of violent families in order to efficiently uncover the violence during therapy sessions and provide appropriate services.     

Estimating the causal effect of randomization versus treatment preference in a doubly randomized preference trial

Although randomized studies have high internal validity, generalizability of the estimated causal effect from randomized clinical trials to real-world clinical or educational practice may be limited. We consider the implication of randomized assignment to treatment, as compared with choice of preferred treatment as it occurs in real-world conditions. Compliance, engagement, or motivation may be better with a preferred treatment, and this can complicate the generalizability of results from randomized trials. The doubly randomized preference trial (DRPT) is a hybrid randomized and nonrandomized design that allows for estimation of the causal effect of randomization versus treatment preference. In the DRPT, individuals are first randomized to either randomized assignment or choice assignment. Those in the randomized assignment group are then randomized to treatment or control, and those in the choice group receive their preference of treatment versus control. Using the potential outcomes framework, we apply the algebra of conditional independence to show how the DRPT can be used to derive an unbiased estimate of the causal effect of randomization versus preference for each of the treatment and comparison conditions. Also, we show how these results can be implemented using full matching on the propensity score. The methodology is illustrated with a DRPT of introductory psychology students who were randomized to randomized assignment or preference of mathematics versus vocabulary training. We found a small to moderate benefit of preference versus randomization with respect to the mathematics outcome for those who received mathematics training.