Is the cerebellum a smith predictor?

The motor system may use internal predictive models of the motor apparatus to achieve better control than would be possible by negative feedback. Several theories have proposed that the cerebellum may form these predictive representations. In this article, we review these theories and try to unify them by reference to an engineering control model known as a Smith Predictor. We suggest that the cerebellum forms two types of internal model. One model is a forward predictive model of the motor apparatus (e.g., limb and muscle), providing a rapid prediction of the sensory consequences of each movement. The second model is of the time delays in the control loop (due to receptor and effector delays, axonal conductances, and cognitive processing delays). This model delays a copy of the rapid prediction so that it can be compared in temporal register with actual sensory feedback from the movement. The result of this comparison is used both to correct for errors in performance and as a training signal to learn the first model. We discuss evidence that the cerebellum could form both of these models and suggest that the cerebellum may hold at least two separate Smith Predictors. One, in the lateral cerebellum, would predict the movement outcome in visual, egocentric, or peripersonal coordinates. Another, in the intermediate cerebellum, would predict the consequences in motor coordinates. Generalization of the Smith Predictor theory is discussed in light of cerebellar involvement in nonmotor control systems, including autonomic functions and cognition.     

The "REST" program: a new treatment system for the oppositional defiant adolescent

This study compared the REST (Real Economy System for Teens) program with traditional talk therapy in the treatment of oppositional defiant adolescents. The REST program uses rules for five target behaviors: room care, personal hygiene, completion of chores, abusiveness, and safety violations. Objective measures and subjective parental ratings were taken. Twenty-five adolescents were assigned to each therapy group. In the REST program the adolescent was provided with only food and shelter. The adolescent had to earn money through the REST allowance program to pay for everything else. Earning the allowance was made contingent upon compliance with all rules for the five target behaviors. The results showed significantly greater improvement on all target behaviors for the REST program than for traditional therapy. In addition, parents of adolescents in the REST group reported that their adolescents seemed happier, more relaxed, and closer to them.     

Stress-induced Fos-like Immunoreactivity in the Pons and the Medulla Oblongata of Rats

Immunoreactivity of the immediate early gene c-fos was used to investigate changes in the activity of brainstem neurons in response to acute stressors like immobilization, formalin-induced pain, cold exposure, hemorrhage and insulin-induced hypoglycemia. Different stressors induced Fos-like immunoreactivity in different pontine and medullary neurons. A single, 3 hour immobilization was found to be a very strong stimulus that activated brainstem catecholaminergic (tyrosine hydroxylase-immunopositive) neurons and cells in the raphe and certain pontine tegmental nuclei, as well as in the reticular formation. Pain, induced by a subcutaneous injection of formalin was also effective on catecholamine-synthesizing neurons and on others cells in the nucleus of the solitary tract. Cold exposure activated cells mainly in the sensory spinal trigeminal and parabrachial nuclei and in the so-called "pontine thermoregulatory area". Moderate Fos-like immunoreactivity was induced by a hypotonic (25%) hemorrhage in medullary catecholaminergic neurons, the nucleus of the solitary tract and the Barrington nucleus. Among stressful stimuli used, insulin-induced hypoglycemia elicited the smallest Fos activation in the lower brainstem. The present observations indicate that different stressors may use different neuronal pathways in the central organization of the stress response.     

The conversion of Paul

This essay extrapolates from recent psychological data on the phenomena of guilt and splitting to possible implications for the understanding of the experience of the Apostle Paul.     

Fetal brain tissue transplants reduce visual deficits in adult rats with bilateral lesions of the occipital cortex

Fetal brain tissue from the occipital or the frontal cortex was implanted into the damaged occipital cortex of adult rats. The animals receiving grafts of embryonic frontal cortex showed partial restoration of brightness discrimination while recipients given homologous implants of occipital cortex were as impaired as those animals with lesions alone. Neither frontal nor occipital grafts aided in the performance of a pattern discrimination problem; both groups of brain-damaged animals were unable to learn the task. Nonetheless, both groups of animals had viable and enlarged grafts with similar neuronal and glial profiles.     

Predictability,controllability, and inoculation against learned helplessness

Nondepressed human subjects were divided into seven groups. On a series of discrimination problems, a helplessness group received insoluble problems, a solvable group received contingent feedback, and a no treatment control group received no feedback. For two other groups insoluble problems were preceded by success feedback on a different task presented according to a fixed ratio (FR) or variable ratio (VR) schedule of reinforcement. Two control groups received either FR or VR schedules of success but were not examined on the discrimination problems. All groups were tested for escape/avoidance performance on a human shuttle box. Both FR and VR schedules produced an inoculation against learned helplessness; escape performance by the helplessness group was significantly worse than that of FR and VR inoculation groups. These latter groups performed similar to the solvable and three control groups. Significantly worse than that of FR and VR inoculation groups. These latter groups performed similar to the solvable and three control groups. Significantly fewer subjects in the VR inoculation group exhibited avoidance responses than their counterparts in the FR inoculation group. despite similar escape performance. The findings indicate that learned helplessness can be prevented in humans and suggest different sources of interference produced by unpredictable and uncontrollable events.     

The interrelationships and reliability of a multilevel behavior-based assessment package for distressed couples

Twenty-six couples interested in improving their marital relationships participated in a multi-level behavior based assessment battery. The measures included self-reported, self-monitored, and observed components, all of which were examined for their interrelationships. Test-retest reliability was carried out with six of the couples. Self-reported measures, self-monitored pleasing behaviors, observed positive nonverbal and some negative verbal interactions were found to be consistent. In general, the various levels of measurement were found to be significantly related to each other. Some of the findings were applied to coercion and reciprocity formulations of marital interactions.