Recommendations for standardized human pedigree nomenclature

The construction of an accurate family pedigree is a fundamental component of a clinical genetic evaluation and of human genetic research. Previous surveys of genetic counselors and human genetic publications have demonstrated significant inconsistencies in the usage of common pedigree symbols representing situations such as pregnancy, termination of pregnancy, miscarriage, and adoption, as well as less common scenarios such as pregnancies conceived through assisted reproductive technologies. The Pedigree Standardization Task Force (PSTF) was organized through the Professional Issues Committee of the National Society of Genetic Counselors, to establish recommendations for universal standards in human pedigree nomenclature. Nomenclature was chosen based on current usage, consistency among symbols, computer compatibility, and the adaptability of symbols to reflect the rapid technical advances in human genetics. Preliminary recommendations were presented for review at three national meetings of human genetic professionals and sent to >100 human genetic professionals for review. On the basis of this review process, the recommendations of the PSTF for standardized human pedigree nomenclature are presented here. By incorporating these recommendations into medical genetics professional training programs, board examinations, genetic publications, and pedigree software, the adoption of uniform pedigree nomenclature can begin. Usage of standardized pedigree nomenclature will reduce the chances for incorrect interpretation of patient and family medical and genetic information. It may also improve the quality of patient care provided by genetic professionals and facilitate communication between researchers involved with genetic family studies.Reprinted with permission from theAmerican Journal of Human Genetics 56:745–752, 1995, The University of Chicago Press. © 1995 by The American Society of Human Genetics. All rights reserved.     

Mental rotation and handedness: differences in object-based and egocentric transformations

This study investigates mental rotation performance of right- and left-handers in object-based and egocentric mental rotation tasks using human body stimuli with an outstretched arm in front and back view. Previous literature suggests that right-handers show a slightly better mental rotation performance than left-handers. 42 participants, 14 left-handers and 28 right-handers, completed a mental rotation task with object-based and egocentric transformation of a human figure which was displayed either in front or back view. The main result was a three-way interaction between the factors “kind of transformation”, “handedness” and “view” in a way, that right-handers show significantly faster reaction times then left-handers in front view object-based transformations because of the additional in-depth rotation for front view stimuli. This difference disappeared in egocentric tasks due to the modification of onés own perspective to solve the task. The results of this study show that right-handers not generally outperform left-handers in mental rotation tasks but only if more cognitive resources are needed.     

The curious case of spillover: Does it tell us much about saccade timing in reading?

In completing daily activities, the eyes make a series of saccades by gazing at stimuli in succession. The duration of gaze on each stimulus has been used to infer how the initiation of a saccade is timed relative to the underlying mental processing. In reading, gaze dwells longer on a word that occurs infrequently in English text (low frequency) than on a more frequent word (high frequency), but also on the following word, which is referred to as spillover. Accounts of spillover attribute it to mechanisms of lexical access. A low-frequency word n is assumed to delay the onset of cognitive processing of word n+1 more than it delays the saccade to n+1, leaving more processing to be done on n+1 once it is fixated. We tested this assumption by having participants perform a series of speeded lexical decisions on a linear array of letter strings spaced 5° apart, using low- and high-frequency words to vary the lexical difficulty. Lexical decision adds a response selection stage that is absent in reading, which should eliminate differential effects on saccades and cognitive processing. Nonetheless, we found the typical pattern of lengthened gaze duration and spillover for low-frequency words, with effects that were consistent in magnitude with those seen in studies of reading. These data challenge existing accounts of spillover and argue against the idea that reading has a unique interaction with oculomotor control. Instead, the similarity of our gaze patterns to those of reading suggests a common pattern of saccade initiation across tasks.     

Electrophysiological correlates of encoding and retrieving emotional events

This study examined the impact of emotional content on encoding and retrieval processes. Event-related potentials were recorded in a source recognition memory task. During encoding, a posterior positivity for positive and negative pictures (250-450 ms) that presumably reflects attentional capturing of emotionally valenced stimuli was found. Additionally, positive events, which were also rated as less arousing than negative events, gave rise to anterior and posterior slow wave activity as compared with neutral and negative events and also showed enhanced recognition memory. It is assumed that positive low-arousing events enter controlled and elaborated encoding processes that are beneficial for recognition memory performance. The high arousal of negative events may interfere with controlled encoding mechanisms and attenuate item recognition and the quality of remembering. Moreover, topographically distinct late posterior negativities were obtained for the retrieval of the context features location and time that support the view that this component reflects processes in service of reconstructing the study episode by binding together contextual details with an item and that varies with the kind of episodic detail to be retrieved.     

Clinical considerations for the treatment of body dysmorphic disorder with cognitive-behavioral therapy

Although cognitive behavior therapy has been found to be very effective in the treatment of body dysmorphic disorder (BDD), there still remain a number of challenges that clinicians face in the treatment of individuals with BDD. In this article, we discuss issues related to comorbid depression, suicidality, substance use disorders, personality disorders as well as the role of early life experiences, delusional intensity of beliefs, and motivation to change. The aim of this review is to provide a treatment aid to clinicians by offering specific recommendations for improved care based on the available literature as well as our clinical experience.     

The mechanism of priming: episodic retrieval or priming of pop-out?

Previous studies indicate that priming affects attentional processes, facilitating processes of target detection and selection on repetition trials. However, the results are so far compatible with two different attentional views that propose entirely different mechanisms to account for priming. The priming of pop-out hypothesis explains priming by feature weighting processes that lead to more frequent selections of nontarget items on switch trials. According to the episodic retrieval account, switch trials conversely lead to temporal delays in retrieving priority rules that specify the target. The results from two eye tracking experiments clearly favour the priming of pop-out hypothesis: Switching the target and nontarget features leads to more frequent selection of nontargets, without affecting the time-course of saccades to a great extent. The results from two more control experiments demonstrate that the same results can be obtained in a visual search task that allows only covert attention shifts. This indicates that eye movements can reliably indicate covert attention shifts in visual search.     

Growing up Faster, Feeling Older: Hardship in Childhood and Adolescence

We examine whether hardship while growing up shapes subjective age identity, as well as three types of experiences through which it may occur. Drawing on data from the National Longitudinal Study of Adolescent Health, we find that hardship in several domains during childhood and adolescence is associated with feeling relatively older and self-identifying as an adult in the late teens and twenties. Specifically, young people who as adolescents felt unsafe in their schools or neighborhoods, witnessed or were victims of violence, had fewer economic resources in the household, and lived in certain family structures, reported older subjective ages (by one or both measures). We find no evidence that hardship's association with subjective age is mediated by work responsibilities in adolescence or by anticipating a very curtailed life span, but entering adult roles earlier mediates or partially mediates many of these relationships.     

A feature-weighting account of priming in conjunction search

Previous research on the priming effect in conjunction search has shown that repeating the target and distractor features across displays speeds mean response times but does not improve search efficiency: Repetitions do not reduce the set size effect—that is, the effect of the number of distractor items—but only modulate the intercept of the search function. In the present study, we investigated whether priming modulates search efficiency when a conjunctively defined target randomly changes between red and green. The results from an eyetracking experiment show that repeating the target across trials reduced the set size effect and, thus, did enhance search efficiency. Moreover, the probability of selecting the target as the first item in the display was higher when the target—distractor displays were repeated across trials than when they changed. Finally, red distractors were selected more frequently than green distractors when the previous target had been red (and vice versa). Taken together, these results indicate that priming in conjunction search modulates processes concerned with guiding attention to the target, by assigning more attentional weight to features sharing the previous target’s color.     

The relation between subitizable symbolic and non‐symbolic number processing over the kindergarten school year

A long‐standing debate in the field of numerical cognition concerns the degree to which symbolic and non‐symbolic processing are related over the course of development. Of particular interest is the possibility that this link depends on the range of quantities in question. Behavioral and neuroimaging research with adults suggests that symbolic and non‐symbolic quantities may be processed more similarly within, relative to outside of, the subitizing range. However, it remains unclear whether this unique link exists in young children at the outset of formal education. Further, no study has yet taken numerical size into account when investigating the longitudinal influence of these skills. To address these questions, we investigated the relation between symbolic and non‐symbolic processing inside versus outside the subitizing range, both cross‐sectionally and longitudinally, in 540 kindergarteners. Cross‐sectionally, we found a consistently stronger relation between symbolic and non‐symbolic number processing within versus outside the subitizing range at both the beginning and end of kindergarten. We also show evidence for a bidirectional relation over the course of kindergarten between formats within the subitizing range, and a unidirectional relation (symbolic → non‐symbolic) for quantities outside of the subitizing range. These findings extend current theories on symbolic and non‐symbolic magnitude development by suggesting that non‐symbolic processing may in fact play a role in the development of symbolic number abilities, but that this influence may be limited to quantities within the subitizing range.