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161.
Hofmann SG 《Behaviour research and therapy》2007,45(9):1987-2001
Combining an effective psychological treatment with conventional anxiolytic medication is typically not more effective than unimodal therapy for treating anxiety disorders. However, recent advances in the neuroscience of fear reduction have led to novel approaches for combining psychological therapy and pharmacological agents. Exposure-based treatments in humans partly rely on extinction to reduce the fear response in anxiety disorders. Animal studies have shown that D-cycloserine (DCS), a partial agonist at the glycine recognition site of the glutamatergic N-methyl-D-aspartate receptor facilitates extinction learning. Similarly, recent human trials have shown that DCS enhances fear reduction during exposure therapy of some anxiety disorders. This article discusses the biological and psychological mechanisms of extinction learning and the therapeutic value of DCS as an augmentation strategy for exposure therapy. Areas of future research will be identified. 相似文献
162.
Page Anderson Elana Zimand Stefan K. Schmertz Mirtha Ferrer 《Cognitive and behavioral practice》2007,14(2):198-207
This study describes the use of a cognitive-behavioral computer-administered self-help program with minimal therapist contact for public speaking anxiety. Participants (N = 10) with social phobia, as measured by a structured clinical interview, completed the self-help program in an open clinical trial. The program was delivered via a CD-ROM during individual sessions at an outpatient clinic, including 4 sessions of psychoeducation/cognitive therapy and 4 sessions of exposure therapy using a virtual audience presented on a computer screen. A therapist was available in another room to answer questions and to debrief for up to 10 minutes after each session. Participants completed standardized self-report questionnaires assessing social anxiety at pretreatment, posttreatment, and 3-month follow-up. Participants also completed measures of computer usability. Results showed decreases on all self-report measures of social anxiety from pre- to posttreatment, which were maintained at follow-up (n = 8). Participants also reported that they were satisfied with treatment, that they felt improved after treatment, and that the computer program was user-friendly. This study provides preliminary evidence that a computer-administered cognitive-behavioral-based program that includes minimal therapist contact may reduce public speaking anxiety and suggests that further research with a controlled design is needed. 相似文献
163.
In a particular success for translational research agendas, characterization of the neuronal circuits underlying fear extinction, and basic research in animal extinction paradigms, has led to intervention studies examining the use of D-cycloserine (DCS) to enhance therapeutic learning from exposure-based cognitive-behavioral therapy (CBT). In this article, we review these intervention studies, and discuss DCS augmentation of CBT relative to more traditional combination-treatment strategies in the treatment of anxiety disorders. We offer an accounting, based on evidence for internal context effects, of current limitations in the combination of antidepressant or benzodiazepine medications with CBT and discuss the advantages of isolated-dosing strategies with DCS relative to these limitations. This strategy is contrasted with the chronic-dosing applications of DCS for schizophrenia and Alzheimer's disease, and future directions for isolated-dosing strategies are discussed. 相似文献
164.
A scale to measure attitudes towards seeking psychological help was developed (Beliefs About Psychological Services [BAPS]) and evaluated. This scale was based on items gathered from students, colleagues, and the authors when asked about common positive and negative attitudes toward psychologists and their services. Items were also based on the Fischer and Turner (1970) Attitudes Toward Seeking Professional Psychological Services (ATSPPH) measure. Three studies are reported describing the construction and evaluation of the psychometric properties of the BAPS. The BAPS is an 18-item measure consisting of three subscales: Intent, Stigma Tolerance, and Expertness. Support was found for the reliability and validity of the measure. 相似文献
165.
Previous research suggests that movements are represented early in practice in visual-spatial coordinates/codes, which are effector independent, and later in practice in motor coordinates/codes (e.g., joint angles, activation patterns), which are effector dependent. In the present experiments, the task was to reproduce 1.3 s patterns of elbow flexions and extensions. An inter-manual transfer paradigm was used in Experiment 1 and an inter-manual practice paradigm was used in Experiment 2. The present results clearly indicated a strong advantage of effector transfer when the motor coordinates available during acquisition were reinstated (Experiment 1) and demonstrate that inter-manual practice with the same motor coordinates results in enhanced retention performance relative to transfer and practice where the same visual-spatial coordinates are used. These results demonstrate that the more effective movement code (motor or visual-spatial) is dependent on the movement sequence characteristics (e.g., difficulty, number of elements, and mode of control [preplanned or on-line]). These results are also interesting because they indicate, contrary to previous findings with more complex movement sequences, that an effective motor code can be developed relatively early in practice for rapid movement sequences. 相似文献
166.
Stefan Kaufmann 《Journal of Philosophical Logic》2009,38(1):1-53
The fact that the standard probabilistic calculus does not define probabilities for sentences with embedded conditionals is
a fundamental problem for the probabilistic theory of conditionals. Several authors have explored ways to assign probabilities
to such sentences, but those proposals have come under criticism for making counterintuitive predictions. This paper examines
the source of the problematic predictions and proposes an amendment which corrects them in a principled way. The account brings
intuitions about counterfactual conditionals to bear on the interpretation of indicatives and relies on the notion of causal
(in)dependence. 相似文献
167.
The radial arm maze is one of the most commonly used tests for assessing working memory in laboratory animals. However, to date, there exists no quantitative method of estimating working memory capacity from performance on this task. Here, we present a mathematical model of performance on the radial arm maze from which we can derive estimates of capacity. We derive explicit results for the two most commonly used measures of performance as functions of number of arms in the maze and memory capacity, assuming a uniform random search. We simulate random non-uniform search strategies. Comparing our model to previous experiments, we show that our model predicts a working memory capacity in the range of 3-9 at the level of performance observed in these experiments. This estimate is within the typical estimate of human working memory capacity. Performance of rats on large mazes (e.g. 48 arms) has been used as evidence that the working memory capacity of rats may be significantly larger than that of humans. We report that memory capacity in the range 3-9 is sufficient to explain the performance of rats in very large radial mazes. Furthermore, when we simulate non-uniform random search strategies observed in the experiments, the resulting estimates do not differ significantly from those assuming a uniform random search. We conclude that a list-based model of working memory with modest capacity is more powerful than previously expected. 相似文献
168.
Maurex L Zaboli G Wiens S Asberg M Leopardi R Ohman A 《Scandinavian journal of psychology》2009,50(1):5-10
The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior. 相似文献
169.
Stefan G. Hofmann Sanna Heering Alice T. Sawyer Anu Asnaani 《Behaviour research and therapy》2009,47(5):389-394
It has been suggested that reappraisal strategies are more effective than suppression strategies for regulating emotions. Recently, proponents of the acceptance-based behavior therapy movement have further emphasized the importance of acceptance-based emotion regulation techniques. In order to directly compare these different emotion regulation strategies, 202 volunteers were asked to give an impromptu speech in front of a video camera. Participants were randomly assigned to one of three groups. The Reappraisal group was instructed to regulate their anxious arousal by reappraising the situation; the Suppression group was asked to suppress their anxious behaviors; and the Acceptance group was instructed to accept their anxiety. As expected, the Suppression group showed a greater increase in heart rate from baseline than the Reappraisal and Acceptance groups. Moreover, the Suppression group reported more anxiety than the Reappraisal group. However, the Acceptance and Suppression groups did not differ in their subjective anxiety response. These results suggest that both reappraising and accepting anxiety is more effective for moderating the physiological arousal than suppressing anxiety. However, reappraising is more effective for moderating the subjective feeling of anxiety than attempts to suppress or accept it. 相似文献
170.
Stefanie Kehrer Antje Kraft Kerstin Irlbacher Stefan P. Koch Herbert Hagendorf Norbert Kathmann Stephan A. Brandt 《Psychological research》2009,73(6):751-761
Event-related potentials were measured to investigate the role of visual spatial attention mechanisms in conflict processing.
We suggested that a more difficult target selection leads to stronger attentional top-down control, thereby reducing the effects
of arising conflicts. This hypothesis was tested by varying the selection difficulty in a location negative priming (NP) paradigm.
The difficult task resulted in prolonged responses as compared to the easy task. A behavioral NP effect was only evident in
the easy task. Psychophysiologically the easy task was associated with reduced parietal N1, enhanced frontocentral N2 and
N2pc components and a prolonged P3 latency for the conflict as compared to the control condition. The N2pc effect was also
obvious in the difficult task. Additionally frontocentral N2 amplitudes increased and latencies of N2pc and P3 were delayed
compared to the easy task. The differences at frontocentral and parietal electrodes are consistent with previous studies ascribing
activity in the prefrontal and parietal cortex as the source of top-down attentional control. Thus, we propose that stronger
cognitive control is involved in the difficult task, resulting in a reduced behavioral NP conflict. 相似文献