Atypical neuropsychological profile in a boy with 22q11.2 Deletion Syndrome.

In this article the general and specific cognitive impairments of the boy R.H. with a de novo deletion 22q11.2 are described. His full-scale IQ was 73, and he obtained only slightly better verbal than non-verbal subtest scores. Neuropsychological assessment revealed specific impairments in perceptual categorization of objects presented suboptimal, matching of unfamiliar faces, and verbal learning and memory. In contrast, he performed in accordance with his intelligence level on other visual perceptual tasks, on non-verbal learning and memory tasks, and on attention tasks. Voxel-wise statistical comparison of a high-resolution T1-weighted magnetic resonance image of R.H's brain with similar images obtained from 14 normal control children revealed as major abnormalities a reduction of the right inferior parietal and superior occipital lobe, and a bilateral reduction of deep white matter behind the inferior frontal gyrus. These cognitive impairments and MRI abnormalities are not commonly described in 22q11.2 Deletion Syndrome and may indicate a larger heterogeneity in the neurocognitive phenotype than currently evidenced. At least in this boy the microdeletion seems to have interfered with the development and functioning of particular neural subsystems, while the structure and functioning of other subsystems was left intact.     

Effects of a family literacy program on low-literate children and their parents: findings from an evaluation of the Even Start family literacy program

A randomized experiment was conducted to test the effectiveness of Even Start, a federally supported family literacy program providing early childhood education, adult education, parenting education, and joint parent-child literacy activities to children and parents from low-literate families. The evaluation of 18 Even Start projects followed 463 families for 2 years and found no statistically significant or educationally important impacts on Even Start families when they were compared with control families on child literacy outcomes, parent literacy outcomes, or parent-child interactions. The study concludes that Even Start projects were able to properly implement family literacy programs, and the observed lack of effectiveness is attributed to a combination of 2 factors: (a) a lack of full participation on the part of families and (b) instructional services that may be ineffective because of the curriculum content or the instructional approach.     

Bright light treatment has limited effect in subjects over 55 years with mild early morning awakening

31 subjects, age 55 yr. or older, suffering from mild early morning awakening were randomized to either a bright light (10,000 lux) or to a red dim light placebo condition (200 lux). Light exposure took place in the evening in the patients' homes, 60 to 30 min. before bedtime and lasted for 3 wk. The subjects kept a sleep diary for 2 wk. and wore an actigraph for 1 wk. both before treatment and at post-treatment. Of the eight sleep diary outcome variables, significant effects that could be attributed to the light treatment were only detected for time spent in bed after final morning awakening. None of the six actigraph outcome variables yielded any significant effect of the light therapy. Explanations for the limited therapeutic effects of bright light treatment obtained in the present study are discussed, such as the criteria defining early morning awakening, the selection procedure, problems with compliance, age of the sample, and the dose of light. The lack of an objective circadian marker in this study could represent a problem concerning the timing of the light exposure. Despite the limited success of bright light therapy in this study, bright light therapy should still be considered as a treatment option for early morning awakening.     

In search of "master mindreaders": are psychics superior in reading the language of the eyes?

Much of the effort to understand the brain substrate of theory of mind and empathy has involved the study of individuals with deficits in that domain, such as those on the autism spectrum. Studying individuals with presumed superior abilities in picking up social signals may yield important additional information. We predicted that psychic readers may have superior abilities and tested this by contrasting a group of 22 professional psychic readers with matched controls on a measure of theory of mind ("Reading the Mind in the Eyes" test) and a multidimensional measure of empathy [Interpersonal Reactivity Index (IRI)]. Although psychic readers were not superior in reading the language of the eyes, they were shown to have more cognitive empathy, as measured with the "Fantasy" subscale of the IRI. We discuss the merits of research involving "experts" in social cognition and propose other possible groups of "master mindreaders."     

Speaker variations influence speechreading speed for dynamic faces

We investigated the influence of task-irrelevant speaker variations on speechreading performance. In three experiments with video digitised faces presented either in dynamic, static-sequential, or static mode, participants performed speeded classifications on vowel utterances (German vowels /u/ and /i/). A Garner interference paradigm was used, in which speaker identity was task-irrelevant but could be either correlated, constant, or orthogonal to the vowel uttered. Reaction times for facial speech classifications were slowed by task-irrelevant speaker variations for dynamic stimuli. The results are discussed with reference to distributed models of face perception (Haxby et al, 2000 Trends in Cognitive Sciences 4 223-233) and the relevance of both dynamic information and speaker characteristics for speechreading.     

Limits to doubt

Supported by Ian Hacking’s concept of “intervention,” and Charles Taylor’s concept of “intentionality,” this article argues that doubting is acting, and that doubting is therefore subject to the same demands of responsibility as any other action. The argument is developed by using medical practice as a test-case. The central suggestion is that the demand of acting responsibly limits doubt in medicine. The article focuses on two such limitations to doubt. Firstly, the article argues that it is irresponsible to doubt that our actions can harm other people. Secondly, the article argues that it is irresponsible not to strive for coherence between our utterances of doubt and our other actions. Incoherence here can cause “cultural impoverishment.” In a larger context this article also argues that medicine can enrich our epistemology, because medical knowledge displays important traits of knowledge that are downplayed in traditional epistemology derived from mathematics and physics. In particular, medicine makes it possible to get the relation between ethics and epistemology into sharper focus. The endpoint in medical epistemology is “responsible action,” and not certainty in and of itself.     

The role of collective identification in social movement participation: a panel study in the context of the German gay movement

The authors conducted a panel study with two points of measurement throughout a 12-month interval in the context of the German gay movement to test the predictive power of collective identification in subsequent actual social movement participation. Regression analyses including cross-lagged panel analyses clearly confirmed the hypothesized unique predictive value of identification with a formal social movement organization above and beyond the role the collective, normative, and reward motives traditionally considered in social movement research. Of the three motives, the normative motive was particularly predictive. Moreover, data from an additional telephone follow-up (3 years after the initial measurement) suggests that when the conflict with political opponents becomes particularly fierce, identification with the broader recruitment category, which was previously ineffective as a unique predictor, can politicize to such an extent that it also becomes a strong predictor of participation.     

Phase-locking and amplitude modulations of EEG alpha: Two measures reflect different cognitive processes in a working memory task

It has been demonstrated in numerous experiments that oscillatory EEG responses in the alpha frequency band (8-12 Hz) increase with memory load during the retention interval in working memory tasks. However, the findings diverge with respect to which measurement of alpha activity is influenced by memory processes. Here, we differentiate between evoked and total alpha activity in order to separate effects of phase-locking and amplitude modulation. We present data from a delayed-matching-to-sample task (S1-S2 paradigm) for which we compared EEG alpha responses between a perception and a memory condition. Increased total alpha activity was found in the retention interval for the memory as compared to the perception condition. Evoked alpha activity, however, did not differentiate between memory and perception conditions but, instead, was increased for the more complex condition of processing non-Kanizsa figures as compared to Kanizsa figures. Thus, our results demonstrate a functional differentiation between evoked and total alpha activity. While alpha phase locking seemed to be influenced mainly by task complexity, alpha amplitude clearly reflected memory demands in our paradigm.     

Bottom-up influences on working memory: behavioral and electrophysiological distraction varies with distractor strength

The present study investigates bottom-up effects serving the optimal balance between focusing attention on relevant information and distractibility by potentially significant events outside the focus of attention. We tested whether distraction, indicated by behavioral and event-related brain potential (ERP) measures, varies with the strength of task-irrelevant deviances. Twenty subjects performed a tone-duration discrimination task (200 or 400 ms sinusoidal tones presented equiprobably). The stimuli were presented with frequent standard (p = 0.84; 1000 Hz) or infrequent deviant (p = 0.16) pitch. These task-irrelevant pitch changes consisted in a frequency increase/decrease of 1%, 3%, 5%, or 10%. Each of them resulted in prolonged reaction times (RT) in the duration discrimination task and elicited the MMN, P3a, and RON components of the ERP. Importantly, these measures did increase as a function of pitch deviance. Separating the individual trials on the 1% deviation level into trials with and without RT prolongation, i.e., behavioral distraction effect, revealed that both subgroups had similar MMN, but P3a and RON were confined to the trials with RT prolongation. Results are interpreted within a model relating preattentive deviance detection, distraction, and working memory.     

"It's not my fault--but only I can change it": counterfactual and prefactual thoughts of managers

In testing for the self-serving bias in performance evaluation, the authors propose that comparing managers' counterfactual and prefactual thoughts about subordinates' performance is more conclusive than the attributional approach and also offers practical advantages. In a study with 120 managers, a 4-way interaction of subordinate performance, temporal perspective, direction, and reference confirmed the predicted pattern. Managers' thoughts about how a weak performance could have been enhanced had external references, but thoughts about how such a performance could be enhanced in the future focused on the leader. This asymmetry was only observed for weak performance. Results are discussed with regard to biases in leaders' performance evaluations and to how counter- and prefactual thoughts could be used for leadership research and practice.