In search of the internal structure of the processes underlying interval timing in the sub-second and the second range: A confirmatory factor analysis approach

One of the earliest accounts of duration perception by Karl von Vierordt implied a common process underlying the timing of intervals in the sub-second and the second range. To date, there are two major explanatory approaches for the timing of brief intervals: the Common Timing Hypothesis and the Distinct Timing Hypothesis. While the common timing hypothesis also proceeds from a unitary timing process, the distinct timing hypothesis suggests two dissociable, independent mechanisms for the timing of intervals in the sub-second and the second range, respectively. In the present paper, we introduce confirmatory factor analysis (CFA) to elucidate the internal structure of interval timing in the sub-second and the second range. Our results indicate that the assumption of two mechanisms underlying the processing of intervals in the second and the sub-second range might be more appropriate than the assumption of a unitary timing mechanism. In contrast to the basic assumption of the distinct timing hypothesis, however, these two timing mechanisms are closely associated with each other and share 77% of common variance. This finding suggests either a strong functional relationship between the two timing mechanisms or a hierarchically organized internal structure. Findings are discussed in the light of existing psychophysical and neurophysiological data.     

How Not to Read Philosophical Investigations: McDowell and Goldfarb on Wittgenstein on Understanding

In a recent article, John McDowell has criticised Warren Goldfarb for attributing an anti‐realist conception of linguistic understanding to Wittgenstein. 1 I argue that McDowell is right to reject Goldfarb's anti‐ realism, but does so for the wrong reasons. I show that both Goldfarb's and McDowell's interpretations are vitiated by the fact that they do not pay attention to Wittgenstein's positive claims about understanding, in particular his claim that understanding is a kind of ability. The cause of this oversight lies in their endorsement of an excessively anti‐systematic or “therapeutic” reading of Wittgenstein.     

Sexist Behavior Undermines Women’s Performance in a Job Application Situation

Can sexist behavior in a job application context threaten women and cause them to underperform on a subsequent cognitive ability test? In a simulated job interview, 46 women and 46 men -- undergraduate and graduate students from the University of Heidelberg, Germany -- were confronted with either sexist (dominant and physically close) behavior by a male interviewer or non-sexist (friendly and neutral) behavior by the same confederate. Participants then solved math items and language-related items from a German standard intelligence test. In accordance with our hypothesis, the results indicated that female participants in the sexist condition performed significantly worse on the mathematical test than female participants in the control condition. The performance of female participants on the language-related test and male participants on both the math and language-related tests did not differ by experimental condition. After the sexist job interview, women’s impaired performance, occurring on the math items only (i.e., specific to the domain in which women are negatively stereotyped), suggests an influence of psychological and interpersonal processes on seemingly objective test outcomes.     

Regulatory job stressors and their within-person relationships with ego depletion: The roles of state anxiety,self-control effort,and job autonomy

Our research aimed at disentangling the underlying processes of the adverse relationship between regulatory job stressors and ego depletion. Specifically, we analyzed whether state anxiety and self-control effort would mediate the within-person relationships of time pressure, planning and decision-making, and emotional dissonance with ego depletion. In addition, we also tested potential attenuating effects of situational job autonomy on the adverse effects of regulatory job stressors on state anxiety, self-control effort, and ego depletion. Based on an experience sampling design, we gathered a sample of 97 eldercare workers who provided data on 721 experience-sampling occasions. Multilevel moderated serial mediation analyses revealed that time pressure and emotional dissonance, but not planning and decision-making, exerted significant serial indirect effects on ego depletion via state anxiety and self-control effort. Finally, we found conditional serial indirect effects of all three regulatory job stressors on ego depletion as a function of job autonomy. Theoretical implications for scholarly understanding of coping with regulatory job stressors are discussed.     

Perceived Rejection in Personality Psychopathology: The Role of Attachment and Gender

Prior research suggests that individuals with higher rates of personality psychopathology are more likely to endorse insecure attachment patterns which can lead to stronger reactions towards perceived rejection. This study investigated how attachment style and gender moderate the strength of the association between personality psychopathology and reactions to perceived rejection. To examine the role of attachment and gender in the relationship between personality psychopathology and reactions to perceived rejection, an undergraduate sample of 150 students, as well as an Amazon Mechanical Turk (MTurk) sample of 278 individuals, completed various personality and attachment self-report measures and watched video clips addressing rejection from parents, peers, and romantic partners. Multivariate analyses of variance and moderation effects suggested that attachment patterns inconsistently moderate maladaptive reactions to rejection, and that gender moderates the relationship between personality psychopathology and externalizing reactions to rejection. Specifically, men with more pronounced Antagonism and Psychoticism trait facets demonstrated a higher propensity towards externalizing and internalizing reactions to rejection than women in these domains.

     

The anaphase promoting complex is required for memory function in mice

Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the APC/C is essential for cell cycle progression it is also expressed in postmitotic neurons where it has been implicated with axonal outgrowth and neuronal survival. In this study we addressed the role of APC/C in learning and memory function by generating mice that lack the essential subunit APC2 from excitatory neurons of the adult forebrain. Those animals are viable but exhibit a severe impairment in the ability to extinct fear memories, a process critical for the treatment of anxiety diseases such as phobia or post-traumatic stress disorder. Since deregulated protein degradation and APC/C activity has been implicated with neurodegeneration we also analyzed the effect of Apc2 deletion in a mouse model for Alzheimer's disease. In our experimental setting loss of APC2 form principle forebrain neurons did not affect the course of pathology in an Alzheimer's disease mouse model. In conclusion, our data provides genetic evidence that APC/C activity in the adult forebrain is required for cognitive function.     

Insulin receptor substrate 2 is a negative regulator of memory formation

Insulin has been shown to impact on learning and memory in both humans and animals, but the downstream signaling mechanisms involved are poorly characterized. Insulin receptor substrate-2 (Irs2) is an adaptor protein that couples activation of insulin- and insulin-like growth factor-1 receptors to downstream signaling pathways. Here, we have deleted Irs2, either in the whole brain or selectively in the forebrain, using the nestin Cre- or D6 Cre-deleter mouse lines, respectively. We show that brain- and forebrain-specific Irs2 knockout mice have enhanced hippocampal spatial reference memory. Furthermore, NesCreIrs2KO mice have enhanced spatial working memory and contextual- and cued-fear memory. Deletion of Irs2 in the brain also increases PSD-95 expression and the density of dendritic spines in hippocampal area CA1, possibly reflecting an increase in the number of excitatory synapses per neuron in the hippocampus that can become activated during memory formation. This increase in activated excitatory synapses might underlie the improved hippocampal memory formation observed in NesCreIrs2KO mice. Overall, these results suggest that Irs2 acts as a negative regulator on memory formation by restricting dendritic spine generation.     

Coherence and Reliability: The Case of Overlapping Testimonies

A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) among testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in scenarios of equivalent testimonies (Olsson and Schubert 2007; Schubert, to appear). My aim is to investigate which coherence measures turn out to be reliability conducive in the more general scenario where the testimonies do not have to be equivalent. It is shown that four measures are reliability conducive in the present scenario, all of which are ordinally equivalent to the Shogenji measure. I take that to be an argument for the Shogenji measure being a fruitful explication of coherence.     

Knowing your own mate value: sex-specific personality effects on the accuracy of expected mate choices

Knowing one's mate value (mate-value accuracy) is an important element in reproductive success. We investigated within- and between-sex differences in this ability in a real-life speed-dating event. A total of 190 men and 192 women filled out a personality questionnaire and participated in speed-dating sessions. Immediately after each date, participants recorded who they would choose as mates and who they expected would choose them. In line with evolutionarily informed hypotheses, results indicated that sociosexually unrestricted men and more agreeable women showed greater mate-value accuracy than sociosexually restricted men and less agreeable women, respectively. These results have important implications for understanding mating behavior and perhaps the origin of sex differences in personality.