中药注射剂有效性及“毒性”的物质基础分析

中药注射剂的有效性得到了临床用药的广泛验证,但带来的安全性（“毒性”）问题也引起业界和社会的广泛关注。本文通过分析中药注射剂和同处方的口服剂有效性和“毒性”的特点,认为中药注射剂的有效性来自于小分子物质,而大分子物质则是导致“毒性”的主要物质基础,进而提出从严监控中药注射剂中的大分子物质是提高中药注射剂的有效策略。     

有氧运动对记忆的影响及其神经生物学机制

有氧运动是氧气充足时运用大型肌肉群进行有节奏的持续运动。有氧运动可以加快工作记忆任务中的反应速度;在记忆编码前和记忆巩固阶段进行高强度有氧运动有助于提升情景记忆;高强度有氧运动可以促进内隐记忆。有氧运动可以促进神经营养因子的产生,引起长时程增强,激活海马等与记忆相关的脑区并促进神经元再生。未来可探究有氧运动开始和持续时间的影响、有氧运动强度和认知参与的影响、有氧运动对不同年龄性别群体的影响以及脑源性神经营养因子的中介作用,从而深入揭示有氧运动对记忆的影响及其神经生物学机制。     

Some boundary conditions for a word superiority effect

A word superiority effect was obtained using a fixed stimulus set, positional certainty of the critical letter, mixed trial type, and instructions to fixate the critical letter. Control experiments established that this effect was not due to lateral masking. Further experiments extended the finding of a fixed-set word superiority effect to other stimulus sets, and to lowercase and mixed-case stimuli. The mixed-case word superiority effect is inconsistent with supraletter feature models of word recognition and, instead, lends support to hierarchical codes models. It was demonstrated that an unusually wide spacing of letters can disrupt the formation of word-level codes, and that wide visual angles are not necessarily disruptive as long as normal spacing is maintained.     

The complexity of developmental predictions from dual process models

Drawing developmental predictions from dual-process theories is more complex than is commonly realized. Overly simplified predictions drawn from such models may lead to premature rejection of the dual process approach as one of many tools for understanding cognitive development. Misleading predictions can be avoided by paying attention to several cautions about the complexity of developmental extrapolations. The complexity of developmental predictions follows from the fact that overall normative responding at a given age derives from several different mental characteristics: (1) the developmental course of Type 1 processing, (2) the developmental course of Type 2 processing, (3) the acquisition of mindware usable by Type 1 processing, (4) the acquisition of mindware usable by Type 2 processing, and (5) the practicing of the mindware available to Type 2 processing to the extent that it is available to be processed in an autonomous manner. The complexity of all these interacting processes and sources of information can sometimes result in U-shaped developmental functions on some heuristics and biases tasks, making younger children look like they are responding more optimally than older children. This is particularly true when the youngest groups are ill-equipped to even understand the task and thus respond randomly. A final caution concerns terminology: The terms normative or rational should be reserved for responses and not attributed to subpersonal processes.