Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients

Introduction

Adaptation to changing situations can be mediated by two strategies: (1) Evaluation of a response and (2) Evaluation of outcome values in relation to objects. Previous studies indicate that response shifting is associated with a network comprising the left frontal cortex and parietal cortex connected by the superior longitudinal fascicle, whereas outcome evaluation is associated with a network consisting of the orbitofrontal cortex, amygdala and uncinate fascicle. However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems.

Methods

We analyzed stimulus response shifting and stimulus outcome shifting in two studies, one fMRI-study on healthy participants and one study on patients with MS involving structural MRI (Diffusion Tensor Imaging, Voxel Based Morphometry, Ventricular volumetry). Two tasks were used, identical in presentation but different in instruction, controlling for effects of lower level processing. In the SRS task, participants had to perform a “Go” or “NoGo” response depending on a stimulus change: if the stimulus remained the same, they had to continue with the former type of response, if it changed they had to adapt their response pattern. In the SOS task they had to perform a “Go” response only if the presented stimulus corresponded to that of an internal alternating series.

Results

fMRI findings showed that SRS is related to a bilateral parietal-premotor network. In the left hemisphere the prefrontal cortex was also involved. SOS was lateralized to the right hemisphere, particularly to the anterior temporal pole and amygdala, and the inferior parietal cortex. MS patients impaired on this task suffered from lesions in the right uncinate fascicle and showed an enlarged right frontal lateral ventricle.

Conclusion

With physically identical tasks, a functional neuronal segregation can be demonstrated for stimulus response shifting (bilateral activations with a focus in the left prefrontal cortex) and stimulus outcome shifting (right anterior temporal lobe and right supramarginal gyrus).     

Socioeconomic Status and Coronary Heart Disease Risk: The Role of Social Cognitive Factors

The aim of this study is to examine existing research on social cognitive factors that may, in part, mediate the relationship between socioeconomic status (SES) and coronary heart disease (CHD). We focus on how social status is 'carried' in the mental systems of individuals, and how these systems differentially affect CHD risk and associated behaviors. To this end, literatures documenting the association of various social cognitive factors (e.g., social comparison, perceived discrimination, and self-efficacy) with cardiovascular disease are reviewed as are literatures regarding the relationship of these factors to SES. Possible mechanisms through which social cognitions may affect health are addressed. In addition, directions for future research are discussed, and a model identifying the possible associations between social cognitive factors, SES, and coronary disease is provided.     

The sense of diachronic personal identity

In this paper, I first consider a famous objection that the standard interpretation of the Lockean account of diachronicity (i.e., one’s sense of personal identity over time) via psychological connectedness falls prey to breaks in one’s personal narrative. I argue that recent case studies show that while this critique may hold with regard to some long-term autobiographical self-knowledge (e.g., episodic memory), it carries less warrant with respect to accounts based on trait-relevant, semantic self-knowledge. The second issue I address concerns the question of diachronicity from the vantage point that there are (at least) two aspects of self—the self of psycho-physical instantiation (what I term the epistemological self) and the self of first person subjectivity (what I term the ontological self; for discussion, see Klein SB, The self and its brain, Social Cognition, 30, 474–518, 2012). Each is held to be a necessary component of selfhood, and, in interaction, they are appear jointly sufficient for a synchronic sense of self (Klein SB, The self and its brain, Social Cognition, 30, 474–518, 2012). As pertains to diachronicity, by contrast, I contend that while the epistemological self, by itself, is precariously situated to do the work required by a coherent theory of personal identity across time, the ontological self may be better positioned to take up the challenge.     

Does European citizenship breed xenophobia? European identification as a predictor of intolerance towards immigrants

The European Union is generally perceived as endorsing universalistic and multi‐cultural values. However, social identity and self‐categorization theories predict that, when certain conditions are met, a negative relation between ingroup identification and tolerance towards outgroup members should be observed. We argue that the creation of the status of ‘Citizen of the Union’ in Maastricht may contribute to meeting those conditions and therefore to increase intolerance towards resident foreigners. If that is the case, a paradoxical situation could emerge, in which people's levels of tolerance towards foreigners would contradict group values. We examined the relations between values associated with Europe, European and national identification, and tolerance towards foreigners through a survey study with a—non‐representative—sample of undergraduate French‐speaking Belgian students. Results show that Europe was generally associated with humanistic values. But they also reveal that strong European identifiers tended to express more xenophobic attitudes than weak European identifiers, whilst national identification was not related with such attitudes. Copyright © 2002 John Wiley & Sons, Ltd.     

Body image, shape, and volumetric assessments using 3D whole body laser scanning and 2D digital photography in females with a diagnosed eating disorder: preliminary novel findings

We piloted three-dimensional (3D) body scanning in eating disorder (ED) patients. Assessments of 22 ED patients (including nine anorexia nervosa (AN) patients, 12 bulimia nervosa (BN) patients, and one patient with eating disorder not otherwise specified) and 22 matched controls are presented. Volunteers underwent visual screening, two-dimensional (2D) digital photography to assess perception and dissatisfaction (via computerized image distortion), and adjunctive 3D full-body scanning. Patients and controls perceived themselves as bigger than their true shape (except in the chest region for controls and anorexia patients). All participants wished to be smaller across all body regions. Patients had poorer veridical perception and greater dissatisfaction than controls. Perception was generally poorer and dissatisfaction greater in bulimia compared with anorexia patients. 3D-volume:2D-area relationships showed that anorexia cases had least tissue on the torso and most on the arms and legs relative to frontal area. The engagement of patients with the scanning process suggests a validation study is viable. This would enable mental constructs of body image to be aligned with segmental volume of body areas, overcoming limitations, and errors associated with 2D instruments restricted to frontal (coronal) shapes. These novel data could inform the design of clinical trials in adjunctive treatments for eating disorders.     

Effects of validity screening items on adolescent survey data

In 2 studies, we examined the use of validity screening items in adolescent survey data. In each study, adolescent respondents were asked whether they were telling the truth and paying attention in answering survey questions. In Study 1 (N = 7,801), the prevalence rates of student risk behaviors were significantly lower after inappropriate (invalid) responders were screened out of the sample. In addition, confirmatory and multigroup factor analyses demonstrated significant differences between the factor structures of school climate scales with valid versus invalid responders. In Study 2, student perceptions of school climate were correlated with teacher perceptions in 291 schools. A bootstrap resampling procedure compared the correlations obtained with valid versus invalid responding students in each school and found that valid responders had more positive views of school conditions and produced higher correlations with teacher perceptions. These findings support the value of validity screening items in improving the quality of adolescent survey data.     

Oculomotor inhibition of return: How soon is it “recoded” into spatiotopic coordinates?

When, in relation to the execution of an eye movement, does the recoding of visual information from retinotopic to spatiotopic coordinates happen? Two laboratories seeking to answer this question using oculomotor inhibition of return (IOR) have generated different answers: Math?t and Theeuwes (Psychological Science 21:1793?C1798, 2010) found evidence for the initial coding of IOR to be retinotopic, while Pertzov, Zohary, and Avidan (Journal of Neuroscience 30:8882?C8887, 2010) found evidence for spatiotopic IOR at even shorter postsaccadic intervals than were tested by Math?t and Theeuwes (Psychological Science 21:1793?C1798, 2010). To resolve this discrepancy, we conducted two experiments that combined the methods of the previous two studies while testing as early as possible. We found early spatiotopic IOR in both experiments, suggesting that visual events, including prior fixations, are typically coded into an abstract, allocentric representation of space either before or during eye movements. This type of coding enables IOR to encourage orienting toward novelty and, consequently, to perform the role of a foraging facilitator.     

Bridging the gap on Facebook: assessing intergroup contact and its effects for intergroup relations

In line with Allport's contact hypothesis, previous research showed that direct intergroup contact can reduce prejudices. However, establishing face-to-face contact is not always feasible. We postulate that Facebook-groups are a setting where direct and observed intergroup contact can develop, reducing prejudices and increasing mutual acceptance. Analyzing the comments of nine Facebook-groups with the destructive and constructive conflict scale, our results indicated that the expression of prejudices decreased and that of mutual acceptance increased over time, both for in- and outgroup members of the Facebook-groups. Only the expression of less prejudices, but not that of more mutual acceptance was predicted by intergroup contact. The influence of group-based motivations on the engagement in intergroup contact is discussed, and the overall findings are integrated in Steele and Brown's process model of media practices.