Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning

Different subregions of the rodent prefrontal cortex (PFC) mediate dissociable types of behavioral flexibility. For example, lesions of the medial or orbitofrontal (OFC) regions of the PFC impair extradimensional shifts and reversal learning, respectively, when novel stimuli are used during different phases of the task. In the present study, we assessed the effects of inactivation of the OFC on strategy set-shifting and reversal learning, using a maze based set-shifting task mediated by the medial PFC. Long–Evans rats were trained initially on a visual-cue discrimination to obtain food. On the subsequent day, rats had to shift to using a response strategy (e.g., always turn left). On Day 3 (reversal), rats were required to reverse the direction of their turn (e.g., always turn right). Infusions of the local anesthetic bupivacaine into the OFC did not impair initial visual discrimination learning, nor did it impair performance on the set-shift. In contrast, inactivation of the OFC did impair reversal learning; yet, these rats ceased using the previously acquired response rule as readily as controls. Instead, rats receiving OFC inactivations made a disproportionate number of erroneous arm entries towards the visual-cue, suggested that these animals reverted back to using the original visual-cue based strategy. These findings, in addition to previous data, further support the notion that the OFC and medial PFC play dissociable roles in reversal learning and set-shifting. Furthermore, the lack of effect of OFC inactivations on the set-shift indicates that this type of behavioral flexibility does not require cognitive operations related to reversal learning.     

Meadow voles, <Emphasis Type="Italic">Microtus pennsylvanicus</Emphasis>, have the capacity to recall the “what”, “where”, and “when” of a single past event

Some non-human animals may possess the ability to recall the “what”, “where”, and “when” of a single past event. We tested the hypothesis that male meadow voles posses the capacity to recall the “what”, “where”, and “when” of a single past event associated with mate selection in two experiments. Briefly, male voles were allowed to explore an apparatus that contained two chambers. One chamber contained a day-20 pregnant female (24 h prepartum). The other chamber contained a sexually mature female that was neither pregnant nor lactating (REF female). Twenty-four hour after the exposure, the males were placed in the same apparatus, which was empty and clean. At this time, the pregnant female would have entered postpartum estrus (PPE), a period of heightened sexual receptivity. Males initially chose and spent significantly more time investigating the chamber that originally housed the pregnant female (now a PPE female) than the chamber that originally housed the REF female. Male voles also explored an apparatus containing a chamber with a PPE female and one chamber containing a REF female. Twenty-four hour later, males were placed into an empty and clean apparatus. The males did not display an initial choice and they spent similar amounts of time investigating the chamber that originally housed the PPE female (now a lactating female) and the chamber that originally housed the REF female. The results of these and additional experiments suggest that male voles may have the capacity to recall the “what”, “where”, and “when” of a single past event, which may allow males to remember the location of females who would currently be in heightened states of sexual receptivity.     

Perfectionism and health: a mediational analysis of the roles of stress, social support and health-related behaviours

This study tested a model derived from personality theory in which perceived stress, perceived social support, health-risk and health-promotion behaviours mediate the relationship between perfectionism and perceived physical health. A sample of 538 undergraduate students completed a web-based survey assessing multi-dimensional perfectionism, perceived stress, perceived social support, health behaviours, physical health and a scale tapping elements of the five-factor model of personality. Analyses that account for the effects of traits from the five-factor model (e.g., neuroticism, conscientiousness and extraversion) indicated that socially prescribed perfectionism was associated with poorer physical health and this association was fully mediated by higher levels of perceived stress and lower levels of perceived social support. Self-oriented perfectionism was related complexly to health such that it was related to poorer health via higher levels of perceived stress, but was also related to better health via higher levels of perceived social support. Our findings illustrate the need for considering key mediators of the link between perfectionism and poor health outcomes.     

Deciphering Subjective Trajectories for Life Satisfaction Using Self‐versus‐Normative Other Discrepancies,Self‐esteem and Hope

Drawing on temporal and social comparison perspectives, we examined sources of the widespread belief that life gets better and better over time by determining how young adults evaluate their past, present and anticipated future life satisfaction (LS) relative to beliefs about normative others. We assessed whether patterns of subjective LS trajectories based on self‐versus‐normative other discrepancies varied as a function of self‐esteem and whether such patterns were accounted for by hope, encompassing goal‐related cognitions and motivations. University participants (n = 394) completed measures of their own and normative others' past, present and anticipated future LS, as well as self‐esteem and hope scales. Results from latent growth curve analyses demonstrated that high‐self‐esteem and low‐self‐esteem individuals perceived normative others' LS as progressing on a similar upward subjective temporal trajectory; however, high‐self‐esteem individuals perceived self‐improvement from past to present LS and self‐consistency from present to future LS relative to others. Low‐self‐esteem individuals perceived self‐consistency from past to present LS and self‐improvement from present to future LS relative to others. These associations were accounted for by hope. This research highlights the utility of combining temporal and social comparison perspectives for understanding how people envision their LS unfolding over time. Copyright © 2012 John Wiley & Sons, Ltd.     

Effects of a post-hospitalization group health education programme for patients with coronary heart disease

Abstract

Effects of a post-hospitolization group health education programme for patients with coronary heart disease. A health education programme was offered to groups of coronary heart patients and their partners after discharge from hospital. A randomized pre-test post-test control group design was used to evaluate the effects of this experimental intervention. The health education programme was offered to 109 coronary heart patients in groups of between five and eight patients together with their partners in addition to standard medical care and physical training. A control group of 108 patients received only standard medical care and physical training.

The intervention consisted of eight weekly two-hour group health education sessions and one follow-up session. All sessions focused on the promotion of healthy habits and the reduction of adverse psychosocial consequences of the incident.

In the short term (about four months after the incident) the health education programme showed statistically significant intervention effects on knowledge about coronary heart diseases, smoking cessation, healthy eating habits and the number of consultations with the family physician, but no effects on emotional distress. In the long term (one year after the incident) there was only a significant intervention effect on smoking cessation.

These results suggest that the effects of the programme are modest, especially in terms of maintenance of behavioural change. As a consequence, it is suggested that the programme should not be offered to all coronary patients during cardiac rehabilitation, but only to those who can be expected to profit most from it.     

The Job Demand-Control-Social Support Model and Wellness/Health Outcomes: A European Study

The EUROTEACH study which is reported here, comprised 2796 secondary school teachers from 13 European countries. The study firstly aimed at testing an extended Job Demand-Control-Social support (JDCS) model and checking its gender specificity. While this study failed to provide evidence for the buffer hypothesis derived from the JDCS-model, the strain hypothesis was mostly supported. Additional job conditions tested in this study proved to be important predictors of the outcome variables (emotional exhaustion, depersonalisation, personal accomplishment, somatic complaints and job satisfaction) and standard of living indicators also added explained variance in these outcomes. The study proved that the JDCS model cannot be called a male model. Secondly the study looked at the comparability of 3 European regions (South, West, East). Apart from important regional differences in job conditions, standard of living indicators and outcomes, the most important finding is that the JDCS model explains most variance in outcome variables in Western Europe, and the least in Eastern Europe, and thus seems to suffer from a Western bias.     

SOCIAL SHARING IN ANTICIPATION OF CARDIAC SURGERY: WHO TALKS MORE AND WHY

This study presents the stress and sharing model, which was developed in order to predict the extent to which patients anticipating cardiac surgery, share their emotions. The model hypothesizes that preoperative sharing of emotions mediated by need, is positively related to surgery-related stress measured independently, and in comparison to the roommates. The model was tested for surgery-related and surgery-unrelated feelings. One hundred and fifty-seven Greek patients participated in the study. The variables included in the model were measured daily, using self-reports. Results show a good fit of the model only for surgery-related feelings (χ²=4.688, p=0.321). The study shows that patients anticipating surgery share their emotions in the same way as patients recovering from stressful or traumatic events. Stressed patients experience the need to focus on the threat (verbally) and not to be ‘distracted’ by talking about irrelevant topics. These findings have important implications for the design of preparatory interventions for surgical patients.     

Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making

Research on the neural basis that underlies decision making in humans has revealed that these processes are mediated by distributed neural networks that incorporate different regions of the frontal lobes, the amygdala, the ventral striatum, and the dopamine system. In the present article, we review recent studies in rodents investigating the contribution of these systems to different forms of cost-benefit decision making and focus on evaluations related to delays, effort, or risks associated with certain rewards. Anatomically distinct regions of the medial and orbital prefrontal cortex make dissociable contributions to different forms of decision making, although lesions of these regions can induce variable effects, depending on the type of tasks used to assess these functions. The basolateral amygdala and the nucleus accumbens play a more fundamental role in these evaluations, helping an organism overcome different costs to obtain better rewards. Dopamine activity biases behavior toward more costly yet larger rewards, although abnormal increases in dopamine transmission can exert opposing actions on different types of decision making. The fact that similar neural circuits are recruited to solve these types of problems in both humans and animals suggests that animal models of decision making will prove useful in elucidating the mechanisms mediating these processes.