Responsiveness to Threat and Incentive in Bipolar Disorder: Relations of the BIS/BAS Scales with Symptoms

Over the past 10 years, theorists have suggested that bipolar disorder symptoms result from increases and decreases in the activity of the Behavioral Activation or Facilitation System (BAS or BFS) and the Behavioral Inhibition System (BIS). These neurobehavioral systems are thought to determine the intensity of affective and behavioral responses to incentives and threats. This study examined cross-sectional and prospective associations of self-reported BIS and BAS with mania and depression in a sample of 59 individuals diagnosed with Bipolar I disorder. Depression was tied to BIS, pointing to the importance of sensitivity to threats in depression. However, links between BIS and depression appeared state-dependent. BAS subscales did not correlate with manic symptoms in a state-dependent manner; however, BAS (total scale and reward responsiveness subscale) predicted relative intensification of manic symptoms over time. Thus, evidence suggests that BAS sensitivity may constitute a vulnerability to mania among persons diagnosed with bipolar disorder. Discussion focuses on the integrative potential of the BIS/BAS constructs for linking psychosocial and biological research on bipolar disorder.     

Infant responsiveness and maternal confidence in the neonatal period

Responsiveness in prematurely and term-born infants was studied cross-sectionally in relation to maternal confidence. Orientation and arousal were measured in 140 prematurely (mean BW 1,398 g, GA 30.1 weeks) and 75 term-born infants (mean BW 3,613 g, GA 39.3 weeks) with the Neonatal Behavioral Assessment Scales. Mothers filled out the Maternal Confidence Questionnaire and a modified version of the Parenting Stress Index. Prematurely born infants had a significantly lower level of arousal than term-born neonates. Responsiveness was not associated with maternal confidence. Lower confidence was associated with primiparity in both groups of mothers. Multiparous mothers of prematurely born infants had significantly lower levels of confidence than multiparous mothers of term-born infants. Confidence was significantly associated with stress for mothers of prematurely and term-born infants, and may be focused in follow-up after giving birth. Prematurely born infants should be examined more thoroughly in aspects of arousal at the time of discharge.     

Different types—Different rights

Drawing on a social construction theory of ownership in biological material this paper discusses which differences in biological material might motivate differences in treatment and ownership rights. The analysis covers both the perspective of the person from whom the material originates and that of the potential recipient. Seven components of bundles of rights, drawing on the analytical tradition of Tony Honoré, and their relationship to various types of biological material are investigated. To exemplify these categories the cases of a heart, a kidney, stem cells and hair are used.     

Audiovisual presentation of video-recorded stimuli at a high frame rate

A method for creating and presenting video-recorded synchronized audiovisual stimuli at a high frame rate—which would be highly useful for psychophysical studies on, for example, just-noticeable differences and gating—is presented. Methods for accomplishing this include recording audio and video separately using an exact synchronization signal, editing the recordings and finding exact synchronization points, and presenting the synchronized audiovisual stimuli with a desired frame rate on a cathode ray tube display using MATLAB and Psychophysics Toolbox 3. The methods from an empirical gating study (Moradi, Lidestam, & Rönnberg, Frontiers in Psychology 4:359, 2013) are presented as an example of the implementation of playback at 120 fps.     

LQTS Parents’ Reflections About Genetic Risk Knowledge and their Need to Know or Not to Know their Children’s Carrier Status

Long QT syndrome (LQTS) is a contributor to unexplained deaths in infants (SIDS), children, teenagers and young adults. A gene test result may allow for individual tailored treatment, but also pose a burden of knowing one’s carrier status, with no treatment recommendation. Genetic risk knowledge in the case of LQTS can promote adjustment and coping, but also fear anxiety, ambivalence and moral dilemmas. This makes it challenging to respect both the right to know and the right not to know. The purpose of this study was to explore LQTS parents’ perception of genetic knowledge, and their need to know or not to know about their children’s carrier status. Qualitative, semi structured interviews were conducted with thirteen parents of LQTS-children. Results show that parents found it important to know the result of a gene test for LQTS including their children’s carrier status. The risk was framed and incorporated into their everyday life and their life perspectives. Pertinent moral dilemmas concerned information disclosure to children and relatives. Parents thought that early and gradual disclosure to children would promote coping. Parents’ moral dilemmas were rarely addressed during encounters with healthcare providers. The participants had several suggestions for improvement in that regard.     

Body ownership affects visual perception of object size by rescaling the visual representation of external space

Size perception is most often explained by a combination of cues derived from the visual system. However, this traditional cue approach neglects the role of the observer’s body beyond mere visual comparison. In a previous study, we used a full-body illusion to show that objects appear larger and farther away when participants experience a small artificial body as their own and that objects appear smaller and closer when they assume ownership of a large artificial body (“Barbie-doll illusion”; van der Hoort, Guterstam, & Ehrsson, PLoS ONE, 6(5), e20195, 2011). The first aim of the present study was to test the hypothesis that this own-body-size effect is distinct from the role of the seen body as a direct familiar-size cue. To this end, we developed a novel setup that allowed for occlusion of the artificial body during the presentation of test objects. Our results demonstrate that the feeling of ownership of an artificial body can alter the perceived sizes of objects without the need for a visible body. Second, we demonstrate that fixation shifts do not contribute to the own-body-size effect. Third, we show that the effect exists in both peri-personal space and distant extra-personal space. Finally, through a meta-analysis, we demonstrate that the own-body-size effect is independent of and adds to the classical visual familiar-size cue effect. Our results suggest that, by changing body size, the entire spatial layout rescales and new objects are now perceived according to this rescaling, without the need to see the body.     

Updating working memory in aircraft noise and speech noise causes different fMRI activations

The present study used fMRI/BOLD neuroimaging to investigate how visual‐verbal working memory is updated when exposed to three different background‐noise conditions: speech noise, aircraft noise and silence. The number‐updating task that was used can distinguish between “substitution processes,” which involve adding new items to the working memory representation and suppressing old items, and “exclusion processes,” which involve rejecting new items and maintaining an intact memory set. The current findings supported the findings of a previous study by showing that substitution activated the dorsolateral prefrontal cortex, the posterior medial frontal cortex and the parietal lobes, whereas exclusion activated the anterior medial frontal cortex. Moreover, the prefrontal cortex was activated more by substitution processes when exposed to background speech than when exposed to aircraft noise. These results indicate that (a) the prefrontal cortex plays a special role when task‐irrelevant materials should be denied access to working memory and (b) that, when compensating for different types of noise, either different cognitive mechanisms are involved or those cognitive mechanisms that are involved are involved to different degrees.