Effects of Aging on Functional Connectivity of the Amygdala for Subsequent Memory of Negative Pictures: A Network Analysis of Functional Magnetic Resonance Imaging Data

ABSTRACT— Aging is associated with preserved enhancement of emotional memory, as well as with age-related reductions in memory for negative stimuli, but the neural networks underlying such alterations are not clear. We used a subsequent-memory paradigm to identify brain activity predicting enhanced emotional memory in young and older adults. Activity in the amygdala predicted enhanced emotional memory, with subsequent-memory activity greater for negative stimuli than for neutral stimuli, across age groups, a finding consistent with an overall enhancement of emotional memory. However, older adults recruited greater activity in anterior regions and less activity in posterior regions in general for negative stimuli that were subsequently remembered. Functional connectivity of the amygdala with the rest of the brain was consistent with age-related reductions in memory for negative stimuli: Older adults showed decreased functional connectivity between the amygdala and the hippocampus, but increased functional connectivity between the amygdala and dorsolateral prefrontal cortices. These findings suggest that age-related differences in the enhancement of emotional memory might reflect decreased connectivity between the amygdala and typical subsequent-memory regions, as well as the engagement of regulatory processes that inhibit emotional responses.     

APPLIED IMPLICATIONS OF REINFORCEMENT HISTORY EFFECTS

Although the influence of reinforcement history is a theoretical focus of behavior analysis, the specific behavioral effects of reinforcement history have received relatively little attention in applied research and practice. We examined the potential effects of reinforcement history by reviewing nonhuman, human operant, and applied research and interpreted the findings in relation to possible applied significance. The focus is on reinforcement history effects in the context of reinforcement schedules commonly used either to strengthen behavior (e.g., interval schedules) or commonly used to decrease behavior (e.g., extinction).     

A comparison of the effects of fimbria-fornix, hippocampal, or entorhinal cortex lesions on spatial reference and working memory in rats: short versus long postsurgical recovery period.

Using a radial maze task and different postoperative recovery periods, this experiment assessed and compared the reference and working memory performances of adult Long-Evans male rats subjected to entorhinal cortex, fimbria-fornix, and hippocampus lesions. Sham-operated rats were used as controls. In order to see whether the duration of the postsurgical recovery period would influence acquisition of the complex radial maze task, training began 1 month following surgery (Delay 1) for half the rats in each group, while for the other half training was started 6.5 months following surgery (Delay 2). The results indicated that at both recovery periods the entorhinal cortex lesions failed to affect either working or reference memory in the spatial task. Conversely, both fimbria-fornix and hippocampus lesions impaired both reference and working memory. While the reference memory deficit was generally similar in both fimbria-fornix and hippocampal lesion groups, analysis of the results for working memory indicated that at the longer delay rats with fimbria-fornix lesions were still impaired but in animals that had the hippocampus removed, working memory did not differ from that of controls. These results suggest that there was some recovery in those rats with hippocampal lesions (e.g., on the working memory task) but both hippocampal and fimbria-fornix animals were still impaired compared to controls when training was delayed 6.5 months following the operations.     

What determines the eyes’ landing position in words?

The place at which the eyes first fixate in a word during continuous reading, called thepreferred landing position(PLP), is usually located halfway between the beginning and the middle of the word. To propose a mechanism that might account for the off-center location of the PLP, six eye movement experiments were conducted using a lexical decision task (Experiment 1) and a stimulus bisection task (Experiments 2–6). The type of stimulus—linguistic (words and nonwords) versus nonlinguistic (strings of hashes, dotted lines, and solid lines)—and the stimulus presentation side (left vs. right) were manipulated. The results showed that (1) stimulus discreteness versus continuousness is an important factor in saccade computation and (2) PLP asymmetry can be explained in terms of attentional and/or oculomotor processes.     

Canadian ethnographic study of sources and definitions of theological reflection in pastoral care and counseling

What are the sources and definitions of theological reflection developed by Canadian practitioners of pastoral care and counseling? This study is part of a larger qualitative research project on theological reflection. This research reviews the literature, describes the ethnographic method, and presents the findings with a sample of 75. Main sources are sacred texts, personal experience, experiences of clients, and traditions of faith group. Definitions are meaning making, discovering the divine and discipleship with recommendations for future research listed.     

Wo steht der Jugendmaßregelvollzug in Deutschland aktuell?

With up to 67% of all young offenders suffering from mental illnesses, the question of how professional care should be arranged for them arises. The ability to detain a young offender for an indefinite period of time in a forensic psychiatric institution represents the final solution in juvenile law. This currently affects approximately 300 patients nationwide, of which there is precise data available only for patients who were detained before the age of 18. This is due to the differing nationwide organisational structures within specific forensic psychiatric institutions for adolescents. There is currently a lack of forensic psychiatric units in several federal states providing treatment for adolescents. When examining under what basis, and when the relocation of a person from a young forensic psychiatric institution into the corresponding adult one occurred, and how long specific pedagogic facilities were provided to these individuals, the differences between various adolescent forensic psychiatric institutions become apparent. This especially concerns young adolescent offenders suffering from delayed mental development.     

A role for backward transitional probabilities in word segmentation?

A number of studies have shown that people exploit transitional probabilities between successive syllables to segment a stream of artificial continuous speech into words. It is often assumed that what is actually exploited are the forward transitional probabilities (given XY, the probability that X will be followed by Y), even though the backward transitional probabilities (the probability that Y has been preceded by X) were equally informative about word structure in the languages involved in those studies. In two experiments, we showed that participants were able to learn the words from an artificial speech stream when the only available cues were the backward transitional probabilities. Learning is as good under those conditions as when the only available cues are the forward transitional probabilities. Implications for some current models of word segmentation, particularly the simple recurrent networks and PARSER models, are discussed.     

How do i know what i feel? Evidence for the role of self‐categorisation in symptom perceptions

This paper extends the self‐categorisation model of symptom appraisals to predict that individuals who believe they have a given illness will perceive concurrent symptoms relevant to that illness to be more severe when they categorise themselves as members of a group of people with that illness. These predictions are supported with opportunity samples of individuals reporting, or not reporting a common cold (Study 1, N = 60) and reporting colds or tinnitus (Study 2, N = 64). In both studies, relevant symptoms were rated as more severe when illness group memberships were salient. The methodological, theoretical and clinical implications of these findings and possible therapeutic applications of self‐categorisation theory (SCT) to symptom perceptions are discussed. Copyright © 2007 John Wiley & Sons, Ltd.     

The information content of panoramic images I: The rotational errors and the similarity of views in rectangular experimental arenas

Animals relocating a target corner in a rectangular space often make rotational errors searching not only at the target corner but also at the diagonally opposite corner. The authors tested whether view-based navigation can explain rotational errors by recording panoramic snapshots at regularly spaced locations in a rectangular box. The authors calculated the global image difference between the image at each location and the image recorded at a target location in 1 of the corners, thus creating a 2-dimensional map of image differences. The authors found the most pronounced minima of image differences at the target corner and the diagonally opposite corner--conditions favoring rotational errors. The authors confirmed these results in virtual reality simulations and showed that the relative salience of different visual cues determines whether image differences are dominated by geometry or by features. The geometry of space is thus implicitly contained in panoramic images and does not require explicit computation by a dedicated module. A testable prediction is that animals making rotational errors in rectangular spaces are guided by remembered views.