Behavioral treatment of insomnia in older adults: an open clinical trial comparing two interventions

Fifty-five insomniacs, 60 years or above, participated in a behavioral treatment program, comparing two interventions (sleep hygiene+stimulus control vs sleep hygiene+relaxation tape). Half of the subjects were randomized to a waiting-list condition prior to treatment. No significant changes were observed during the waiting-list period. During the treatment period however, the subjects improved on several sleep parameters, and treatment gains were maintained at a 6-month follow-up. The effects of treatment were greater for nocturnal measures (e.g. sleep onset latency and total sleep time) as compared to daytime measures (e.g. life satisfaction, daytime alertness) and not-targeted behavior (medication use). There were no differences in treatment effects for the two interventions.     

Distributed cortical networks for syntax processing: Broca's area as the common denominator

Different types of syntactic information (word category, grammatical gender) are processed at different times during word recognition. However, it is an open issue which brain systems support these processes. In the present event-related fMRI study, subjects performed either a syntactic gender decision task on German nouns (GEN), a word category decision task (WC, nouns vs. prepositions), or a physical baseline task (BASE). Reaction times in WC were faster than in GEN, supporting earlier electrophysiological results. Relative to BASE, both syntactic tasks activated the inferior tip of BA 44. In addition, BA 45 showed activation in GEN, whereas BA 47 was activated in WC. The imaging data indicate that the inferior portion of BA 44 together with type-specific prefrontal areas supports both initial word category related and later syntactic processes.     

Illusory illusions: the significance of fixation on the perception of geometrical illusions

Some well-known geometrical illusions disappear when the eyes are fixating and saccades are suppressed for a period of time. This disappearance is not accompanied by fading due to stabilisation of the retinal image. Any saccade made on purpose restores the illusion immediately. The fixation time after which some illusions disappeared was measured for four illusions and four subjects each. Effects of practice have been observed after measurements were repeated on successive days. Present theories of vision cannot readily explain the effect.     

Day treatment of patients with personality disorders: experiences from a Norwegian treatment research network

This study sought to investigate the following research questions: Are time-limited day treatment programs for patients with personality disorder (PD) effective outside resourceful university settings, and what are the overall treatment results when the program is implemented on a larger scale? Do all categories and subtypes of PDs respond favorably to such treatment? How intensive should such day treatment programs be? All patients (n = 1,244) were consecutively admitted to eight different treatment programs in the Norwegian Network of Psychotherapeutic Day Hospitals from 1993 to 2000. Altogether, 1,010 patients were diagnosed with PD. Avoidant, borderline, not otherwise specified (NOS), and paranoid PD were the most common conditions. SCID-II and MINI were used as diagnostic instruments. Outcome measures included GAF Global Assessment of Functioning, (GAF; American Psychiatric Association, 1994), SCL-90R, CIP, Quality of Life, work functioning and parasuicidal behavior, measured at admittance, discharge and 1-year follow up. The attrition rate was 24%. The number of dropouts did not improve over time. As a group, completers with PD improved significantly on all outcome variables from admittance to discharge and improvement was maintained or increased at follow up. Treatment results were best for borderline PD, cluster C patients, PD NOS and No PD, and poorer for cluster A patients. Units with a high treatment dosage did not experience better outcomes than those with a low treatment dosage (10 hours per week). Results from the University unit were not better than those from units at local hospitals or mental health centers.     

What the Liar Taught Achilles

Zeno's paradoxes of motion and the semantic paradoxes of the Liar have long been thought to have metaphorical affinities. There are, in fact, isomorphisms between variations of Zeno's paradoxes and variations of the Liar paradox in infinite-valued logic. Representing these paradoxes in dynamical systems theory reveals fractal images and provides other geometric ways of visualizing and conceptualizing the paradoxes.     

Vienna Indeterminism: Mach,Boltzmann, Exner

The present paper studies a specific way of addressing the question whether the laws involving the basic constituents of nature are statistical. While most German physicists, above all Planck, treated the issues of determinism and causality within a Kantian framework, the tradition which I call Vienna Indeterminism began from Mach’s reinterpretation of causality as functional dependence. This severed the bond between causality and realism because one could no longer avail oneself of a priori categories as a criterion for empirical reality. Hence, an independent reality criterion had to be sought, a problem which all three physicists to be studied solved in different ways that were mainly conditioned by their different concepts of probability. In order to prevent a dissipation of intuited facts, Mach had to resort to a principle of unique determination as his reality criterion, especially when discussing the Principle of Least Action. Giving theories more independence, Boltzmann understood atomism as property reduction to precisely defined theoretical entities and their interactions. While this served as a relative reality criterion, he also advocated a constructivist one because atomism was already implied by our finitary reasoning power. Finally, Exner contemplated the idea that all apparently deterministic laws are only a macroscopic limit of an irreducible indeterminism, because by adopting the frequency interpretation, observable collectives could be considered as the real basic entities. This revised version was published online in June 2006 with corrections to the Cover Date.     

Measurement of visual aftereffects and inferences about binocular mechanisms in human vision

There is conflicting evidence concerning the characteristics of binocular channels in the human visual system with respect to the existence of a 'pure' binocular channel that responds only to simultaneous stimulation of both eyes. Four experiments were conducted to resolve these discrepancies and to evaluate the evidence for the existence of such an exclusive binocular channel. In the first three studies, tilt aftereffects were measured after monocular adaptation. The relative sizes of the direct, interocularly transferred, and binocular aftereffects were not influenced by the configuration of the adapting pattern (experiment 1), or by the eye used for adaptation (experiment 2). There were also consistent interobserver differences in the relative sizes of the aftereffect seen after monocular adaptation (experiment 3). Taken together, these data raise questions about the appropriateness of a monocular adaptation paradigm for evaluating the presence of a pure binocular channel in observers with normal binocular vision. In experiment 4, in which the paradigm of alternating monocular adaptation was used, data were obtained that are consistent with the presence of a pure binocular channel.     

Pharmacological dissociation of memory: anisomycin, a protein synthesis inhibitor, and leupeptin, a protease inhibitor, block different learning tasks

Inhibition of protein synthesis by anisomycin for a short duration impairs memory of a one-trial inhibitory avoidance task in rats. Memory of escape conditioning involving eight trials is disrupted only if the duration of protein synthesis is prolonged by repeated injections. In marked contrast, olfactory memory of rats trained on two odor discriminations is not affected by anisomycin even if the duration of inhibition is prolonged and the number of trials is reduced to a minimum. In previous work, leupeptin, a thiol proteinase inhibitor, was shown to impair olfactory discrimination learning, but left inhibitory and avoidance conditioning intact. Together, these results provide a pharmacological double dissociation of memory, and suggest that the same chemistries, or mixtures of chemistries, may not be involved in all types of memory.     

Grandiose-Manipulative,Callous-Unemotional,and Daring-Impulsive: the Prediction of Psychopathic Traits in Adolescence and their Outcomes in Adulthood

There has been much debate about how to measure psychopathic traits in adolescence. One of the main issues is whether one should focus on callous-unemotional (CU) traits alone, or CU traits in combination with Grandiose-Manipulative (GM) and Daring-Impulsive (DI) traits. The current study first investigates the extent to which youth who are high on CU traits are also high on GM and DI traits. In addition, the study investigates if being high on both CU and GM, and high on both CU and DI, identify groups that are particularly characterized by past and future impairments. To investigate this, data from the Cambridge Study in Delinquent Development (CSDD) was analyzed. The CSDD is a prospective longitudinal study of 411 English boys spanning over 50 years. The information available at age 12–14 was coded on the Antisocial Process Screening Device (APSD). Childhood risk factors were measured at age 8–10 and later life outcomes were measured at age 32. The results indicate that being high on CU in combination with DI delineates a clinically interesting group who are characterized by high childhood risk and poorer adult life outcomes. The same applied to the high CU/high GM group, but to a lesser extent.