Pathogen spectrum in bacterial meningitis in childhood and subsequent therapeutic strategy

In a total of 223 children over one month old suffering from purulent meningitis, there was a predominance (n = 96) of meningococci over hemophilus influenzae (n = 68) and pneumococci (n = 59). Crucial to therapeutic strategy for purulent meningitis is early diagnosis, in our laboratory covering both liquor and blood cultures. Initial therapy has to take account of these three chief causal agents. We have not as yet observed any resistance to penicillin from meningococci or pneumococci, and none of the liquor-cultivated hemophilus influenzae stock has been resistant to ampicillin. In the first two years of life, initial therapy for bacterial meningitis should include ampicillin, a liberal (300-400 mg/kg KM/d) dosage continuing to be important after the onset of improvement. In view of the lack of resistance of the causal agents cultivated, we had hitherto no cell to deploy modern cephalosporins in cases of bacterial meningitis in children.     

Hemispheric specialization for speech opposed,by contralateral noise

Twenty right-handed Ss listened to a dichotic tape in which one of six consonant-vowel syllables was paired with a burst of white noise on each trial. Eight blocks of 40 trials were presented, with the syllables within a block presented to, the same ear. On each trial, Ss decided if/ ba/ was presented. Mean RT to right-ear items was 440.0 msec, while mean left-ear RT was 453.6 msec. Responses indicating the presence of /ba/ were made significantly more quickly than responses indicating its absence, with no significant interaction of ear and type of decision. This study demonstrated a right-ear advantage in the perception of spoken syllables when noise is presented to the opposite ear. An interpretation of the RT differences between ears in terms of callosal transmission time is discussed, and implications of this study for the perceptual origins of the ear advantage effect are considered.     

The relationship between psychological test results and EEG patterns in healthy children

222 children (112 girls and 110 boys) aged 5–16 years with different types of EEG pattern, selected according to well defined normal criteria in order to exclude cerebral lesion elements, were investigated by current child-psychiatric diagnostic methods, including the Wechsler Intelligence Scale for children (WISC), which gave a mean IQ of 116.5. With two so-called tests of organicity (Bender Gestalt Test and Benton's Revised Visual Retention Test) poor performances indicating brain damage were shown in 22% and 24% of the children respectively. Various EEG patterns showed few significant correlations with the test variables. According to clinical judgement "slight symptoms of cerebral dysfunction" was found in some children, but no correlation appeared between such symptoms and poor performance in the psychological tests. The high frequency of defective scores in the Bender and Benton tests in this selected material of healthy children means that these tests cannot be used in clinical work for diagnosing brain injury in individual children. Nor can they be used to throw light on the clinical significance of the different EEG variables studied.     

Perceptual boundedness and perceptual support in conceptual development.

A theoretical framework for describing the role of perceptual information in early conceptual development is presented. In the main section of the article, a general operationalization of perceptual boundedness is introduced, 3 causes of this limitation are identified, the conditions under which infants and children seem to be perceptually bound are formulated, and the mechanisms by which this limitation declines are described. Traditional claims that young children are perceptually bound, as well as contemporary objections to these claims, are often based on the assumption that perceptual information is generally unveridical or insufficient. Recent doubts about this assumption are evaluated in the final section of the article. It is concluded that although realist arguments are untenable, there are limited forms of perceptual support for conceptual development.     

Vulnerability of skeletal and autonomic manifestations of memory in the rat to electroconvulsive shock.

A series of experiments was performed to probe the phenomenon of sparing of memory by electroconvulsive shock (ECS) when amnesia is assessed by autonomic indices. Differential vulnerability of memory as indexed by skeletal and autonomic responses was determined to be a function of a higher threshold to disruption for autonomically indexed memories. Autonomic responses spared by ECS were found to reflect underlying memory rather than artifact produced by nonassociative factors arising from the interaction of conditioned stimulus (CS), unconditioned stimulus (US), and ECS. Furthermore, retrograde amnesia gradients of different slopes were observed with skeletal and autonomic measures. Two interpretations of these phenomena are discussed. One hypothesis suggests that individual components of a memory are consolidated at different rates, whereas the other concerns the differentail sensitivity of various measures in assessing memory.     

Publishers Note

Publishers Note

Publishers Note     

Parameters affecting gap detection in the rat

The present research used a startle amplitude reduction paradigm to investigate the ability of the rat’s auditory system to track rapidly changing acoustic transients. Specifically examined was the ability of brief gaps in otherwise continuous noise to reduce the amplitude of a subsequently elicited acoustic startle reflex. The duration of the gap, time between gap offsetand startle elicitation (the interstimulus interval or ISI), and rise-fall characteristics of the gap were systematically varied. Consistent with previous research, gaps reliably reduced startle amplitude. Gaps 2 msec long were reliably detected, and a 50-msec ISI resulted in the greatest amplitude reduction. Gaps presented at short ISIs produced amplitude reduction that followed a different time course than did gaps presented at longer ISIs. These results may reflect differences in the length oftime available for the processing of the stimulus and may involve two different processes.     

The relation between syllable number and visual complexity in the acquisition of word meanings

Four experiments were conducted to explore the correlation between syllable number and visual complexity in the acquisition of novel words. In the first experiment, adult English speakers invented nonsense words as names for random polygons differing in visual complexity. Visually simple polygons received names containing fewer syllables than visually complex polygons did. In addition, analyses of English word-object pairings indicated that a significant correlation between syllable number and visual complexity exists in the English lexicon. In Experiments 2 and 3, adult English speakers matched monosyllabic novel words more often than trisyllabic novel words with visually simple objects, whereas trisyllabic matches were more common for visually complex objects. Experiment 4 replicated these findings with children, indicating that the assumption of a correlation between word and visual complexity exists during the period of intense vocabulary growth. Although the actual correlation between syllable number and visual complexity is small, other posited constraints on word meaning are also limited in strength. However, an increasing number of small, language-specific word-meaning correlations are being uncovered. Given the documented ability of speakers to detect and use these subtle correlations, we argue that a more fruitful approach to word-meaning acquisition would forgo the search for a few broad, powerful word-meaning constraints, and we attempt to uncover individually weak, but perhaps jointly powerful word-meaning correspondences.