Heterogeneity in Verbal Memory: A Marker of Preclinical Alzheimer's Disease?

ABSTRACT

Demonstrations of memory changes in those at risk for Alzheimer's disease by the presence of the APOE e4 allele have been inconsistent to date. The present study went beyond traditional analyses of central tendency (i.e., group differences on mean test scores) and also conducted distribution analyses to search for subtle cognitive differences in subgroups of normal-functioning elderly persons with the APOE e4 genotype. The results of the study revealed that (a) the e4 and non-e4 groups failed to differ in terms of their mean scores on tests of memory and verbal skills; and (b) relative to the non-e4 group, the e4 subjects had significantly greater heterogeneity of variance on the memory measures but not on fundamental verbal skills. Logistic regression analyses indicated that the discrepancy in scores on the memory measures was a significant predictor of genotype group membership (82% correct classification rate). Implications of these findings for the detection of a preclinical phase of AD are discussed.     

The procreative asymmetry and the impossibility of elusive permission

Philosophical Studies - This paper develops a form of moral actualism that can explain the procreative asymmetry. Along the way, it defends and explains the attractive asymmetry: the claim...     

Associations between Stress,Psychosomatic Complaints,and Parental Criticism among Affluent Adolescent Girls

A growing body of research has shown that adolescent girls in the context of affluence face a series of unique pressures that may increase social-emotional problems. Little research, however, has examined associations between perceived stress and psychosomatic complaints among privileged youth. In the present study, we investigated the relationships between stress, psychosomatic complaints, and parental criticism in a sample of preadolescent and adolescent girls (n?=?218) from selective, private schools. Using OLS regression analyses, cross-sectional and longitudinal associations were evident between perceived stress and psychosomatic complaints, with increases in stress associated with increases in psychosomatic problems. Parental criticism was also examined as a predictor of girls’ psychosomatic complaints and stress levels. Results indicated that parental criticism was significantly and positively associated with psychosomatic problems in cross-sectional models and that perceived stress levels mediated this association. Additional analyses demonstrated that the relationship between psychosomatic complaints and stress may be bidirectional. Taken together, results from this exploratory study suggest that girls in the context of affluence may also experience psychosomatic complaints, in addition to social-emotional problems.     

The Laruellean Clinamen: François Laruelle and French Atomism

According to François Laruelle, French thought has been unduly influenced by corpuscular or atomist thinking, yet Laruelle has himself employed key atomist terms—in particular, that of the clinamen or swerve—in framing his own style of thought. This essay looks at this tension between atomism and anti-atomism in Laruelle’s thought, taking the measure of his contribution to a larger stream of postwar French thinking about the relevance and stakes of ancient atomism. Its contention is that Laruelle subtly but really outlines a quantum theoretical resumption of ancient atomist philosophy—one that deserves closer attention and comparative study in the larger context of French philosophical interest in the atomists. A first section of the paper briefly describes Laruelle’s general project, along with his claim that he differs from his contemporaries because he uniquely escapes the dangers of what he calls corpuscular thought. A second section addresses the apparent tension between Laruelle’s claim to produce a non-corpuscular thinking and his consistent recent use of the atomist image of the clinamen, ultimately arguing that Laruelle sides with the clinamen against two forms of corpuscularity supposedly avoided by the clinamen itself but nonetheless usefully embodied in atomist thought. The final section of the paper draws up in preliminary terms a comparison between Laruelle’s understanding of his relationship to atomism and that of his contemporaries, focusing in particular on Alain Badiou.