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Demonstrations of memory changes in those at risk for Alzheimer's disease by the presence of the APOE e4 allele have been inconsistent to date. The present study went beyond traditional analyses of central tendency (i.e., group differences on mean test scores) and also conducted distribution analyses to search for subtle cognitive differences in subgroups of normal-functioning elderly persons with the APOE e4 genotype. The results of the study revealed that (a) the e4 and non-e4 groups failed to differ in terms of their mean scores on tests of memory and verbal skills; and (b) relative to the non-e4 group, the e4 subjects had significantly greater heterogeneity of variance on the memory measures but not on fundamental verbal skills. Logistic regression analyses indicated that the discrepancy in scores on the memory measures was a significant predictor of genotype group membership (82% correct classification rate). Implications of these findings for the detection of a preclinical phase of AD are discussed.  相似文献   
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Connectivity among semantic associates: an fMRI study of semantic priming   总被引:1,自引:0,他引:1  
Semantic priming refers to a reduction in the reaction time to identify or make a judgment about a stimulus that has been immediately preceded by a semantically related word or picture and is thought to result from a partial overlap in the semantic associates of the two words. A semantic priming lexical decision task using spoken words was presented in event-related fMRI and behavioral paradigms. Word pairs varied in terms of semantic relatedness and the connectivity between associates. Thirteen right-handed subjects underwent fMRI imaging and 10 additional subjects were tested in a behavioral version of the semantic priming task. It was hypothesized priming would be greatest, reaction time fastest, and cortical activation reduced the most for related word pairs of high connectivity, followed by related word pairs of low connectivity, and then by unrelated word pairs. Behavioral and fMRI results confirmed these predictions. fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing.  相似文献   
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The present study investigated the relationship between imagery use, leisure-time exercise, and exercise self-efficacy within a diverse range of exercisers. One hundred and sixty-two participants (Mage = 23.84; SD = 7.09; 97 female, 65 male) completed the Exercise Imagery Inventory (EII; Giacobbi, Hausenblas, &; Penfield, 2005 Giacobbi, P. R., Hausenblas, H. A. and Penfield, R. D. 2005. Further refinements in the measurement of exercise imagery: The Exercise Imagery Inventory. Measurement in Physical Education and Exercise Science, 9: 251266. [Taylor &; Francis Online] [Google Scholar]), the Leisure-Time Exercise Questionnaire (Godin &; Shepherd, 1985 Godin, G. and Shepard, R. J. 1985. A simple method to assess exercise behavior in the community. Canadian Journal of Applied Sport Science, 10: 141146. [PubMed] [Google Scholar]), and an exercise self-efficacy scale (Rodgers &; Sullivan, 2001 Rodgers, W. M., Munroe, K. and Hall, C. 2001. Relations among exercise imagery, self-efficacy, exercise behavior, and intentions. Imagination, Cognition, and Personality, 21: 5565.  [Google Scholar]) directly following an exercise session. The EII was also modified to include two rating scales of visual and kinesthetic imagery ability. Separate hierarchical multiple regression analyses determined that appearance-health imagery significantly predicted exercise behavior and coping efficacy, and technique imagery significantly predicted task efficacy (all p < .001). Furthermore, exercisers’ abilities to create appearance-health images moderated the relationship between imagery frequency and leisure-time exercise, coping efficacy, and scheduling efficacy (all p < .05). These findings suggest that appearance-health and technique imagery may lead to an increase in exercise behavior and self-efficacy beliefs.  相似文献   
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The development of programmed, actuarial interpretation of personality tests, especially the MMPI, is discussed. The presentation seeks to present a synoptic overview of the topic, including its more important trends, apparent present status, and possible consequences. Several commercially available systems are described, and an example of the output of each of three of them, in interpreting the same MMPI protocol, is presented for comparative illustration.  相似文献   
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This study examines the effects of self-control and social bonds on delinquent behavior in a nationally representative sample. It is proposed that both self-control and social bonds affect delinquency and that the effects of these factors interact with each other. These hypotheses were tested in a regression model controlling for race, gender, delinquent association, and illegitimate opportunity. As predicted, low self-control is positively related to juvenile delinquency while social bonds are negatively related to delinquency. Some of the interaction terms between self-control and social bonds significantly impact delinquency, suggesting that the effects of self-control and social control are interdependent.  相似文献   
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We identified the information used to anticipate throw direction in handball. In two experiments, we examined how anticipation performance is affected when the information from one of five body areas (right arm, shoulders, hips, trunk, or total throw side) was either neutralized or decoupled from the motion of other body segments. In the first experiment, performance was significantly reduced when information from the throwing arm was neutralized, irrespective of skill levels. Skilled participants were negatively affected when the shoulders, hips, and trunk were neutralized, whereas less-skilled participants showed trends toward improvement under identical conditions. In the second experiment, partially disrupting relative motion via decoupling was not enough to reduce the anticipation performance among skilled participants to chance levels, whereas less-skilled participants lost their ability to anticipate in three conditions. Our findings suggest that skilled and less-skilled participants employ different information extraction strategies, yet information from the throwing arm is critical to anticipation for both groups. The two experiments suggest that relative motion mediated by both the absolute displacement trajectories of individual marker locations and their relative timings are important in informing anticipation, irrespective of skill level.  相似文献   
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International seminarians seeking an education at academic institutions located in the United States often face a host of learning challenges. Seminary faculty that teach in these institutions are often confronted with a need to adjust their teaching methods to facilitate learning by international students. This essay outlines specific strategies to facilitate academic success of international seminarians by offering specific teaching methods for faculty and learning strategies for international students. Topics include training faculty in how to respond to diverse learning styles, expanding learning environments beyond the classroom, methods for enhancing student participation, and development of assignments. Strategies for student success include developing skills in how to improve note taking, critical reading, and writing.  相似文献   
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