Family Therapy with Couples and Individuals with Parkinson’s Disease

Family therapists are increasingly called upon to work with individuals and families with medical issues, but often do not have sufficient background on the issue to be most helpful. The purpose of this paper is to help family therapists understand Parkinson’s Disease (PD) and its impact on the individual and his or her family. PD is the second most prevalent neurodegenerative disorder in the United States, following Alzheimer’s disease (Hirtz et al., Neurology 68:326–337, 2007). According to the Parkinson’s Disease Foundation, approximately 60,000 individuals are diagnosed with PD every year, and approximately one million Americans are currently living with PD. In this paper, we provide an overview of PD based on research and the second author’s many years of providing services for individuals with PD, as well as offer specific recommendations for providing family therapy using narrative, solution-focused and emotionally focused therapy based on the first author’s work as a family therapist with individuals, groups, and couples dealing with PD.     

Non‐Bayesian Noun Generalization in 3‐ to 5‐Year‐Old Children: Probing the Role of Prior Knowledge in the Suspicious Coincidence Effect

It is unclear how children learn labels for multiple overlapping categories such as “Labrador,” “dog,” and “animal.” Xu and Tenenbaum (2007a) suggested that learners infer correct meanings with the help of Bayesian inference. They instantiated these claims in a Bayesian model, which they tested with preschoolers and adults. Here, we report data testing a developmental prediction of the Bayesian model—that more knowledge should lead to narrower category inferences when presented with multiple subordinate exemplars. Two experiments did not support this prediction. Children with more category knowledge showed broader generalization when presented with multiple subordinate exemplars, compared to less knowledgeable children and adults. This implies a U‐shaped developmental trend. The Bayesian model was not able to account for these data, even with inputs that reflected the similarity judgments of children. We discuss implications for the Bayesian model, including a combined Bayesian/morphological knowledge account that could explain the demonstrated U‐shaped trend.     

Task-irrelevant visual motion and flicker attenuate the attentional blink

Our reduced ability to correctly report two sequentially presented targets is seen in the robust effect known as the attentional blink (AB; Raymond, Shapiro, & Arnell, 1992). One recent report (Olivers & Nieuwenhuis, 2005) strikingly reveals the AB to be virtually abolished when non-task-demanding music occurs in the background. The authors suggest that a diffuse attentional state is the mediating factor. Here, we seek to broaden the finding’s generality by determining if task-irrelevant visual motion and flicker also attenuate the AB. In our experiments, the AB task was presented together with a background field of moving dots that could moveaway from ortoward the central AB task, or flicker. In the control condition, the dots remained static. The AB was attenuated—though to different degrees—in all experimental conditions, but not in the static condition. Our findings add to the generality of the previous conclusions, and we emphasize an account based on the overallocation of attention.     

Heterogeneity in verbal memory: a marker of preclinical Alzheimer's disease?

Demonstrations of memory changes in those at risk for Alzheimer's disease by the presence of the APOE e4 allele have been inconsistent to date. The present study went beyond traditional analyses of central tendency (i.e., group differences on mean test scores) and also conducted distribution analyses to search for subtle cognitive differences in subgroups of normal-functioning elderly persons with the APOE e4 genotype. The results of the study revealed that (a) the e4 and non-e4 groups failed to differ in terms of their mean scores on tests of memory and verbal skills; and (b) relative to the non-e4 group, the e4 subjects had significantly greater heterogeneity of variance on the memory measures but not on fundamental verbal skills. Logistic regression analyses indicated that the discrepancy in scores on the memory measures was a significant predictor of genotype group membership (82% correct classification rate). Implications of these findings for the detection of a preclinical phase of AD are discussed.     

Resampling probability values for differences between two independent indices of ordinal variation and consensus

A permutation method is presented to calculate resampling probability values for differences between two independent indices of ordinal variation and consensus.     

Exact and resampling probability values for measures associated with ordered r by c contingency tables

Permutation procedures to compute exact and resampling probability values associated with measures of association for ordered r x c contingency tables are described. Comparisons with asymptotic probability values demonstrated that exact and resampling permutation procedures were preferred for sparse contingency tables.     

A measure of effect size for r x c contingency tables

Goodman and Kruskal's tau measure of categorical association is advanced as a replacement for conventional measures of effect size for r x c contingency tables. Goodman and Kruskal's tau is an asymmetric measure of categorical association which is based entirely on the observed data and possesses a clear interpretation in terms of proportional reduction in error. Comparisons with conventional measures of effect size based on chi-squared such as Pearson's phi2, Tschuprow's T2, and Cramer's V2 demonstrate the advantages of employing tau as a measure of effect size.     

Connectivity among semantic associates: an fMRI study of semantic priming

Semantic priming refers to a reduction in the reaction time to identify or make a judgment about a stimulus that has been immediately preceded by a semantically related word or picture and is thought to result from a partial overlap in the semantic associates of the two words. A semantic priming lexical decision task using spoken words was presented in event-related fMRI and behavioral paradigms. Word pairs varied in terms of semantic relatedness and the connectivity between associates. Thirteen right-handed subjects underwent fMRI imaging and 10 additional subjects were tested in a behavioral version of the semantic priming task. It was hypothesized priming would be greatest, reaction time fastest, and cortical activation reduced the most for related word pairs of high connectivity, followed by related word pairs of low connectivity, and then by unrelated word pairs. Behavioral and fMRI results confirmed these predictions. fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing.