Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism

We previously showed that a systemic administration of the selective non-peptide neurokinin-1-receptor (NK-1-R) antagonist SR140333 increases hippocampal acetylcholine levels and facilitates long term memory. In the present study, we investigated whether systemic SR140333 has beneficial effects on episodic-like memory for unique experiences. Rats received either no injection, a vehicle injection or SR140333 at doses of 1, 3 and 9 mg/kg (i.p.) prior to the acquisition of an object memory for what, where and when. In line with previous results, untreated rats showed episodic-like memory, while vehicle-injected rats were impaired. A low dose of 1mg/kg SR140333 reinstated episodic-like memory. This result might be related to the effects of SR140333 on hippocampal cholinergic transmission and/or on the stress-response elicited by the injection procedure. Higher doses of SR140333 (3 and 9 mg/kg) induced psychomotor effects, including stereotypic behaviors and arched posture. Since NK-1-R antagonists have anxiolytic and promestic properties and induce hippocampal acetylcholine release at lower doses, they might be effective in the alleviation of the cognitive deficits and increased anxiety seen in early stages of Alzheimer's disease.     

The role of cultural and spiritual expressions in affirming a sense of self,place, and purpose among young urban,Indigenous Australians

This article sets out to discuss the impact that urban living has had on the lives of young Indigenous people. It will seek to discover some of the problems that occur when there is a meeting of two cultures, in this case the Indigenous culture of Australian Aboriginal people and the mainstream culture that has been derived largely from west European traditions which, in turn, was born out of Western Christian perspectives. As well, it will explore the challenges faced by minority groups who live in pluralist contexts when they attempt to hand on their ways to their young people, in particular, the difficulties faced by urban Indigenous Australians who try to ensure that their young people will develop knowledge about their cultural and spiritual heritage. Finally it will examine how the rights of young Indigenous people need to be protected so that they can continue to develop their particular identity and at the same time take their place with pride and integrity in the pluralist social context that defines Australia today.

Many Australians understand that Aboriginal people have a special respect for nature. The identity we have with the land is sacred and unique. Many people are beginning to understand this more. Also there are many Australians who appreciate that Aboriginal people have a very strong sense of community. All persons matter. All of us belong and there are many more Australians who understand that we are people who celebrate together.

What I want you to know about is another special quality of my people. I believe it is most important. It is our most unique gift. It is perhaps the greatest gift we can give to our fellow Australians. In our language it is the quality called dadirri. It is inner, deep listening and quiet, still awareness.

Dadirri recognizes the deep spring inside us. We call on it and it calls to us. This is the gift that Australia is thirsting for. It is something like what you call ‘contemplation’. (Ungunmerr, 2003 Ungunmerr, Miriam‐Rose. 2003. “Dadirri—The spring within”. In Dadirri: the spring within—the spiritual art of the Aboriginal people from Australia’s Daly River region, Edited by: Farrelly, E. vii–ix. Darwin, NT, , Australia: Terry Knight and Associates.  [Google Scholar])     

Retro-cue benefits in working memory without sustained focal attention

In working memory (WM) tasks, performance can be boosted by directing attention to one memory object: When a retro-cue in the retention interval indicates which object will be tested, responding is faster and more accurate (the retro-cue benefit). We tested whether the retro-cue benefit in WM depends on sustained attention to the cued object by inserting an attention-demanding interruption task between the retro-cue and the memory test. In the first experiment, the interruption task required participants to shift their visual attention away from the cued representation and to a visual classification task on colors. In the second and third experiments, the interruption task required participants to shift their focal attention within WM: Attention was directed away from the cued representation by probing another representation from the memory array prior to probing the cued object. The retro-cue benefit was not attenuated by shifts of perceptual attention or by shifts of attention within WM. We concluded that sustained attention is not needed to maintain the cued representation in a state of heightened accessibility.     

A Systematic Review of Psychiatric and Psychosocial Comorbidities of Genetic Generalised Epilepsies (GGE)

Psychiatric disorders and associated poor psychosocial outcomes are recognised to be a common sequelae of epilepsy. The extent to which this is true of genetic generalised epilepsies (GGE), particularly syndromes other than juvenile myoclonic epilepsy (JME) is unclear. This systematic review synthesises findings regarding psychiatric and associated comorbidities in adults and children with GGE. Systematic review yielded 34 peer-reviewed studies of psychiatric and psychosocial outcomes in adults and children with GGE. Clinically significant psychiatric comorbidity was reported in over half of all children and up to a third of all adults with GGE. There was no evidence to support the presence of personality traits specific to JME or other syndromes; rather rates mirrored community samples. A small number of studies report poor psychosocial outcomes in GGE, however the interpretation of these findings is limited by paucity of healthy comparison groups. Some evidence suggests that anti-epileptic drug polytherapy in children and seizure burden at all ages may constitute risk factors for psychopathology. Findings highlight the importance of early screening so as not to overlook early or developing symptoms of psychopathology.     

The NK3 receptor agonist senktide ameliorates scopolamine-induced deficits in memory for object, place and temporal order

Senktide, a potent neurokinin-3 receptor (NK₃-R) agonist, increases acetylcholine (ACh) release in the striatum, the prefrontal cortex (Schäble et al., 2011), the amygdala and hippocampus, presumably via postsynaptic mechanisms. A promnestic action of NK₃-R agonists has been described in a variety of learning/memory tasks. The memory-enhancing effects of NK₃-R agonists and their activating influence on ACh suggest a possible role of the NK₃-R in learning and memory via cholinergic modulation. Deterioration of the cholinergic system in the basal forebrain has been associated with learning and memory deficits and cholinergic agents have promnestic effects in a variety of learning paradigms. The anticholinergic drug, scopolamine, a muscarinic ACh receptor antagonist, incurs deficits in a variety of learning tasks and provides a useful tool to investigate the role of the cholinergic systems in mechanisms underlying learning and memory. The aim of this study was to ascertain the effect of the NK₃-R agonist, senktide, in the scopolamine-induced deficit model. We hypothesized that senktide treatment would attenuate scopolamine-induced (subcutaneous – s.c. 0.75 mg/kg) memory impairment in three novelty preference paradigms based on spontaneous object exploration: namely object recognition, object–place recognition and object recognition for temporal order. Administration of senktide reversed the scopolamine-induced memory deficits by re-establishing object recognition (s.c. 0.2 mg/kg), object–place recognition (0.2 and 0.4 mg/kg), as well as object recognition for temporal order (0.4 mg/kg) in adult Wistar rats. These results indicate memory enhancing effects of senktide in animals subjected to scopolamine-induced memory impairments and indicate that the promnestic action of NK₃-R agonists is mediated by muscarinic cholinergic mechanisms.     

Processing of representations in declarative and procedural working memory

The article investigates the relation between declarative and procedural working memory (WM; Oberauer, 2009). Two experiments test the assumption that representations in the two subsystems are selected for processing in analogous ways. Participants carried out a series of decisions on memorized lists of digits. For each decision, they had to select declarative and procedural representations. Regarding declarative representations, participants selected a memory set and a digit within this set as the input to each decision. With respect to the procedural representations, they selected a task set to be applied to the selected digit and a response within that task set. We independently manipulated the number of lists and the number of tasks to be switched among (one, two, or three; Experiment 1) and preparation time for a list switch (Experiment 2). For three effects commonly observed in task-switch studies, analogues in declarative WM were found: list-switch costs, mixing costs, and residual switch costs. List- and task-switch costs were underadditive, suggesting that declarative and procedural representations are selected separately and in parallel. The findings support the hypothesis of two analogous WM subsystems.     

Disordered Eating in Women's Gymnastics: Perspectives of Athletes,Coaches, Parents,and Judges

This study examined the knowledge base and perspectives of current and retired gymnasts, parents, coaches and judges with respect to disordered eating in gymnasts. Surveys were designed for this study and included open-ended questions, Likert scales, and checklists. The results indicated that various discrepancies existed between the groups' reports. For example, the retired gymnasts reported more eating disorders and negative views of their experiences than did the current gymnasts. The coaches attributed the use of unhealthy weight control practices to other coaches but not to themselves. Gymnasts who received disparaging comments about their bodies or instructions to lose weight had significantly more disordered eating patterns than those who had not received such comments. The importance of one's social environment on eating and weight control practices is emphasized. Every group recommended further education about nutrition, adolescent development, body image, and psychological well-being. Limitations and future recommendations are addressed.