The NK3 receptor agonist senktide ameliorates scopolamine-induced deficits in memory for object, place and temporal order

Senktide, a potent neurokinin-3 receptor (NK₃-R) agonist, increases acetylcholine (ACh) release in the striatum, the prefrontal cortex (Schäble et al., 2011), the amygdala and hippocampus, presumably via postsynaptic mechanisms. A promnestic action of NK₃-R agonists has been described in a variety of learning/memory tasks. The memory-enhancing effects of NK₃-R agonists and their activating influence on ACh suggest a possible role of the NK₃-R in learning and memory via cholinergic modulation. Deterioration of the cholinergic system in the basal forebrain has been associated with learning and memory deficits and cholinergic agents have promnestic effects in a variety of learning paradigms. The anticholinergic drug, scopolamine, a muscarinic ACh receptor antagonist, incurs deficits in a variety of learning tasks and provides a useful tool to investigate the role of the cholinergic systems in mechanisms underlying learning and memory. The aim of this study was to ascertain the effect of the NK₃-R agonist, senktide, in the scopolamine-induced deficit model. We hypothesized that senktide treatment would attenuate scopolamine-induced (subcutaneous – s.c. 0.75 mg/kg) memory impairment in three novelty preference paradigms based on spontaneous object exploration: namely object recognition, object–place recognition and object recognition for temporal order. Administration of senktide reversed the scopolamine-induced memory deficits by re-establishing object recognition (s.c. 0.2 mg/kg), object–place recognition (0.2 and 0.4 mg/kg), as well as object recognition for temporal order (0.4 mg/kg) in adult Wistar rats. These results indicate memory enhancing effects of senktide in animals subjected to scopolamine-induced memory impairments and indicate that the promnestic action of NK₃-R agonists is mediated by muscarinic cholinergic mechanisms.     

Disordered Eating in Women's Gymnastics: Perspectives of Athletes,Coaches, Parents,and Judges

This study examined the knowledge base and perspectives of current and retired gymnasts, parents, coaches and judges with respect to disordered eating in gymnasts. Surveys were designed for this study and included open-ended questions, Likert scales, and checklists. The results indicated that various discrepancies existed between the groups' reports. For example, the retired gymnasts reported more eating disorders and negative views of their experiences than did the current gymnasts. The coaches attributed the use of unhealthy weight control practices to other coaches but not to themselves. Gymnasts who received disparaging comments about their bodies or instructions to lose weight had significantly more disordered eating patterns than those who had not received such comments. The importance of one's social environment on eating and weight control practices is emphasized. Every group recommended further education about nutrition, adolescent development, body image, and psychological well-being. Limitations and future recommendations are addressed.     

Universal sex differences in the desire for sexual variety: tests from 52 nations, 6 continents,and 13 islands

Evolutionary psychologists have hypothesized that men and women possess both long-term and short-term mating strategies, with men's short-term strategy differentially rooted in the desire for sexual variety. In this article, findings from a cross-cultural survey of 16,288 people across 10 major world regions (including North America, South America, Western Europe, Eastern Europe, Southern Europe, Middle East, Africa, Oceania, South/Southeast Asia, and East Asia) demonstrate that sex differences in the desire for sexual variety are culturally universal throughout these world regions. Sex differences were evident regardless of whether mean, median, distributional, or categorical indexes of sexual differentiation were evaluated. Sex differences were evident regardless of the measures used to evaluate them. Among contemporary theories of human mating, pluralistic approaches that hypothesize sex differences in the evolved design of short-term mating provide the most compelling account of these robust empirical findings.     

Mixed models,random utilities,and the triangle inequality

A new probabilistic binary choice model, which we call the mixed model is proposed. This model is used to give an interpretation of probabilistic choice behavior in terms of complete and partial orders. The model is used as a guide to disprove Jacob Marschak's conjecture that the binary random utility model is equivalent to the triangle inequality. Another result is presented concerning the relation between moderate stochastic transitivity and the triangle inequality.     

Age-Related Hearing Loss: Implications for Counseling

As the U.S. population ages, counseling practitioners are working with increasing numbers of hearing-impaired older adults. Age-related hearing loss affects various dimensions of the counseling process, in which communication is of primary importance. More generally, hearing loss has consequences for the overall lifestyle of the client and for effective functioning in the workplace and in social and family contexts. This article examines adaptation strategies used by hearing-impaired listeners and the implications of age-related hearing loss for counseling, intervention, and self-management.     

Advancing Creativity Theory and Research: A Socio-cultural Manifesto

This manifesto, discussed by 20 scholars, representing diverse lines of creativity research, marks a conceptual shift within the field. Socio-cultural approaches have made substantial contributions to the concept of creativity over recent decades and today can provide a set of propositions to guide our understanding of past research and to generate new directions of inquiry and practice. These propositions are urgently needed in response to the transition from the Information Society to the Post-Information Society. Through the propositions outlined here, we aim to build common ground and invite the community of creativity researchers and practitioners to reflect up, study, and cultivate creativity as a socio-cultural phenomenon.     

Teaching reading and spelling: exclusion and stimulus equivalence

In Experiment 1, 7 nonreading children were exposed to a program designed to teach reading of 51 training words. The program featured an exclusion-based procedure in which the children (a) matched printed to dictated words and (b) constructed (copied) printed words with movable letters and named them. All children learned to read the training words. Five children also read generalization words and showed progress in spelling. Experiment 2 applied the program to 4 different children, omitting the word-construction task. They also learned to read the training words, but only 1 participant read generalization words. The data support a stimulus equivalence account of reading acquisition and suggest that reading generalization may be obtained, especially when the teaching program includes word construction.     

Reorganization of Equivalence Classes After Reversal of Baseline Relations

The Psychological Record - Pilgrim and Galizio (1995) reversed baseline conditional discriminations after the emergence of equivalence classes. College students’ performance was consistent...     

Negative affect as a predisposing factor for cortisol release after an acute stress--the impact of unpleasant priming

Glucocorticoids have a key role in stress responses. There are, however, substantial differences in cortisol reactivity among individuals. We investigated if affective trait and mood induction influence the reactivity to psychological stress in a group of 63 young adults, male (n=27) and female (n=36), aged ca. 21 years. On the experimental day the participants viewed either a block of pleasant or unpleasant pictures for 5 min to induce positive or negative mood, respectively. Then, they had 5 min to prepare a speech to be delivered in front of a video-camera. Saliva samples were collected to measure cortisol, and questionnaire-based affective scales were used to estimate emotional states and traits. Compared to basal levels, a cortisol response to the acute speech stressor was only seen for those who had first viewed unpleasant pictures and scored above the average on the negative affect scale. There were no sex differences. In conclusion, high negative affect associated with exposure to an unpleasant context increased sensitivity to an acute stressor, and was critical to stimulation of cortisol release by the speech stressor.     

Multideductive Logic And The Theoretic-Formal Unification Of Physical Theories

We present a kind of logic named multideductive logic and outline an application of it in the problem of theoretic-formal unification of physical theories dealing with the Bohr atom theory. This is just a preliminary study that will be developed in future papers.