老年甲状腺结节的诊治经验

介绍笔者及科室老年甲状腺结节的诊治经验,对2003年1月至2009年12月期间共收治的144例年龄大于60岁的老年甲状腺结节患者进行分析和总结。老年甲状腺结节以多发为主;压迫症状、异物和不适感、继发性甲状腺功能亢进是老年甲状腺结节患者主要的手术指证;术中发现喉返神经和甲状旁腺有脂肪沉着;病理方面良性结节的钙化率较高;患者术后切口水肿比较明显;暂时性低钙血症的发生率较高;虽然术前麻醉ASA评分较低,但术后心肺并发症的发生率并未上升。老年甲状腺结节患者以全麻为宜,最好采用双甲近全切除术,这不仅可避免术后复发和再次手术率,更可减少甲状腺素制剂的用量,减少药物副作用。     

安德瑞·高兹哲学思想研究评述

对于中国学界来说,安德瑞·高兹(AndréGorz,1924—)绝对算不上是一个陌生的名字。早在1982年出版的《“西方马克思主义”》一书中,徐崇温先生就对高兹做过介绍,在他稍后的另一本著作《“西方马克思主义”论丛》(1989年)中,徐先生也有一篇专门介绍高兹思想的长文。并且,在一年后出版的由罗伯特·戈尔曼编的《“新马克思主义”传记辞典》的中译本中也有“高兹”这一词条,并有相关的论述。1990年出版的《马克思主义哲学史》(8卷本)中也有对高兹的论述。同年出版的李青宜先生的《“西方马克思主义”的当代资本主义理论》一书中用两节的篇幅对…     

Do behavioural self-blame and stigma predict positive health changes in survivors of lung or head and neck cancers?

Survivors of lung or head and neck cancers often change tobacco and alcohol consumption after diagnosis, but few studies have examined other positive health changes (PHCs) or their determinants in these groups. The present study aims to: (a) document PHCs in survivors of lung (n?=?107) or head and neck cancers (n?=?99) and (b) examine behavioural self-blame and stigma as determinants of PHCs. We hypothesised that: (a) survivors would make a variety of PHCs; (b) behavioural self-blame for the disease would positively predict making PHCs; and (c) stigma would negatively predict making PHCs.

Methods: Respondents self-administered measures of PHC, behavioural self-blame, and stigma. Hierarchical multiple regression analysis tested the hypotheses.

Results: More than 65% of respondents reported making PHCs, the most common being changes in diet (25%), exercise (23%) and tobacco consumption (16.5%). Behavioural self-blame significantly predicted PHCs but stigma did not. However, both behavioural self-blame and stigma significantly predicted changes in tobacco consumption.

Conclusions: Many survivors of lung or head and neck cancers engage in PHCs, but those who do not attribute the disease to their behaviour are less likely to do so. Attention to this problem and additional counselling may help people to adopt PHCs.     

社会应激对成年后进行群体隔离的大白鼠的行为的影响

本文观察了在成年后进行群体隔离的大白鼠与群居鼠在摄食、饮水、睡眠等方面的行为差异。着重观察了社会应激对成年后进行群体隔离的动物的行为的影响,以研究群体隔离时动物的年龄与过去生活经验是不是动物在社会应激时发生的行为改变的关键因素。 结果表明:群居与隔离两种环境对动物摄食、饮水和体重无明显影响,但隔离动物睡眠时间较群居动物短。即使在成年后进行群体隔离、社会应激对隔离动物的摄食、饮水、睡眠和攻击性行为的影响也比群居组明显。但进行群体隔离时动物的年龄和隔离前有较长时间的群居生活经验可大大减轻社会应激时行为反应的强度,也可使适应过程发生得快些。这说明早期环境和过去生活经验的重要性。社会应激影响饮水和摄食的方式随年龄而改变,年龄较大的群居鼠对社会应激的适应可能比年龄较轻的群居鼠差。     

Assessing intentional binding with the method of constant stimuli

Intentional binding describes the phenomenon that actions and their effects are perceived to be temporally approximated. We introduced a new method of duration estimation to the research field, the method of constant stimuli. Participants freely chose to press one of two keys or experienced passive key presses. After an interval of 250ms or 600ms a visual effect occurred. In Experiment 1, each key produced an effect after a specific interval. In Experiment 2, both keys produced an effect after the same interval that varied between sessions. Participants compared the duration of the action-effect interval with a tone of varying duration. To assess intentional binding, we compared the perceived duration of the action-effect interval between the active and passive condition. We showed intentional binding for 600ms, but not for 250ms action-effect intervals in both experiments. Thus, the method of constant stimuli is suitable to assess intentional binding.     

Neural correlates of establishing, maintaining, and switching brain states

Although the study of brain states is an old one in neuroscience, there has been growing interest in brain state specification owing to MRI studies tracing brain connectivity at rest. In this review, we summarize recent research on three relatively well-described brain states: the resting, alert, and meditation states. We explore the neural correlates of maintaining a state or switching between states, and argue that the anterior cingulate cortex and striatum play a critical role in state maintenance, whereas the insula has a major role in switching between states. Brain state may serve as a predictor of performance in a variety of perceptual, memory, and problem solving tasks. Thus, understanding brain states is critical for understanding human performance.     

Associative memory or algorithmic search: a comparative study on learning strategies of bats and shrews

Two common strategies for successful foraging are learning to associate specific sensory cues with patches of prey ("associative learning") and using set decision-making rules to systematically scan for prey ("algorithmic search"). We investigated whether an animal's life history affects which of these two foraging strategies it is likely to use. Natterer's bats (Myotis nattereri) have slow life-history traits and we predicted they would be more likely to use associative learning. Common shrews (Sorex araneus) have fast life-history traits and we predicted that they would rely more heavily on routine-based search. Apart from their marked differences in life-history traits, these two mammals are similar in body size, brain weight, habitat, and diet. We assessed foraging strategy, associative learning ability, and retention time with a four-arm maze; one arm contained a food reward and was marked with four sensory stimuli. Bats and shrews differed significantly in their foraging strategies. Most bats learned to associate the sensory stimuli with the reward and remembered this association over time. Most shrews searched the maze using consistent decision-making rules, but did not learn or remember the association. We discuss these results in terms of life-history traits and other key differences between these species. Our results suggest a link between an animal's life-history strategy and its use of associative learning.