Studies on gene–environment interactions suggest that some individuals may be more susceptible to life adversities than others due to their genetic profile. This study assesses whether or not children with an extra X chromosome are more vulnerable to the negative impact of early life stress on cognitive functioning than typically-developing children.
A total of 50 children with an extra X chromosome and 103 non-clinical controls aged 9 to 18 years participated in the study. Cognitive functioning in domains of language, social cognition and executive functioning were assessed. Early life stress was measured with the Questionnaire of Life Events. High levels of early life stress were found to be associated with compromised executive functioning in the areas of mental flexibility and inhibitory control, irrespective of group membership. In contrast, the children with an extra X chromosome were found to be disproportionally vulnerable to deficits in social cognition on top of executive dysfunction, as compared to typically-developing children. Within the extra X group the number of negative life events is significantly correlated with more problems in inhibition, mental flexibility and social cognition. It is concluded that children with an extra X chromosome are vulnerable to adverse life events, with social cognition being particularly impacted in addition to the negative effects on executive functioning. The findings that developmental outcome is codependent on early environmental factors in genetically vulnerable children also underscores opportunities for training and support to positively influence the course of development. 相似文献
This article explores the matching process at micro-, meso-, and macro-levels in health services in order to arrive at culturally competent and gender-sensitive health care. We provide a brief overview of sex, gender, ethnicity, and health, specifically in terms of sex and ethnic matching at micro-, meso-, and macro-levels. Throughout the article we raise some controversial elements surrounding matching by providing a discussion of studies conducted in this field. In conclusion we examine the challenges to sex and ethnic matching in order to provide recommendations and alternative strategies toward the achievement of culturally competent and gender-sensitive health care. 相似文献
Social Psychology of Education - A longitudinal science intervention with students from ethnic-racial underrepresented groups in an urban area examined the roles of intervention participation and... 相似文献
Continental Philosophy Review - The paper investigates phenomenology’s possibilities to describe, reflect and critically analyse political and legal orders. It presents a... 相似文献
It has been proposed that, whilst implicit attitudes, alike beliefs, are propositionally structured (Mandelbaum Noûs, 50(3), 629–658, 2016), the former respond to evidence and modulate other attitudes in a fragmented manner, and so constitute a sui generis class, the “patchy endorsements” (Levy Noûs, 49(4), 800–823, 2015). In the following, I demonstrate that the patchy endorsements theorist is committed to the truth of two claims: (i) no implicit attitude is responsive to content to the same extent as any belief; and (ii) there is a significant gap between the most responsive implicit attitude and the least responsive belief. I argue that both (i) and (ii) fail to hold. Many implicit attitudes respond to evidence and modulate other attitudes. Meanwhile, at least some ordinary beliefs exhibit lower evidence-responsiveness and inferential efficacy than at least some implicit attitudes, defeating (i) and (ii). A better interpretation is that attitudes may be ordered along a continuum according to their responsiveness to content. At one extreme end, we find attitudes usually identified as implicit, and at the other, attitudes usually identified as beliefs, but in the middle, there is an area of overlap. I consider the consequences of the continuum view for existing folk psychological concepts.
Human voices are extremely variable: The same person can sound very different depending on whether they are speaking, laughing, shouting or whispering. In order to successfully recognise someone from their voice, a listener needs to be able to generalize across these different vocal signals (‘telling people together’). However, in most studies of voice-identity processing to date, the substantial within-person variability has been eliminated through the use of highly controlled stimuli, thus focussing on how we tell people apart. We argue that this obscures our understanding of voice-identity processing by controlling away an essential feature of vocal stimuli that may include diagnostic information. In this paper, we propose that we need to extend the focus of voice-identity research to account for both “telling people together” as well as “telling people apart.” That is, we must account for whether, and to what extent, listeners can overcome within-person variability to obtain a stable percept of person identity from vocal cues. To do this, our theoretical and methodological frameworks need to be adjusted to explicitly include the study of within-person variability.
Two experiments using different procedures were performed in which newborns’ ability to process information about object shape with their hands was explored. In the first experiment, a haptic fixed‐trial procedure was used and a decrease in holding times was found for both right and left hands. In the second experiment, discrimination between objects was studied in which a shifted procedure associated to an infant‐control procedure followed by a dishabituation procedure was used. Habituation to an object and a reaction to the novelty of a new object were shown for both right and left hands, showing that neonates are able to process and encode some information about object shape and then to discriminate between different shapes. It is the first evidence of such an ability in neonates. Methodological procedure and haptic cognition with regard to sensory symmetry are discussed and some developmental perspectives are proposed. 相似文献
Schreuder and Baayen (Schreuder. R., & Baayen, R. H. (1997). How complex simplex words can be. Journal of Memory and Language 37, 118-139) report that lexical decision times to nouns are not sensitive to the cumulative frequency of the noun's morphological derivatives in its "morphological family", even though such a cumulative frequency effect is obtained in the domain of inflection. Under a decomposition view of derivational morphology, this constitutes a puzzling exception to the robust finding that lexical frequency is one of the major determinants of behavioral response latencies. If morphologically complex words are decomposed, each occurrence of a member of a noun's morphological family should add to its root-frequency. We investigated the effects of morphological family frequency on the magnetoencephalographic response component M350, which shows sensitivity to factors affecting early stages of lexical processing, including lexical frequency. We hypothesized that high morphological family frequency should have a facilitory effect on the M350, even though no such effect can be seen in response time, presumably due to competition among possible root-affix combinations. Contrary to this hypothesis, we found that high family frequency elicits an M350 inhibition, suggesting that competition among morphological family members occurs at the M350. The result is significant, since there is evidence that competition among phonologically similar words occurs after, not at, the M350. Thus, our results suggest that competition within a morphological family precedes competition within a phonological similarity neighborhood. 相似文献
Spatial information processing takes place in different brain regions that receive converging inputs from several sensory modalities. Because of our own movements—for example, changes in eye position, head rotations, and so forth—unimodal sensory representations move continuously relative to one another. It is generally assumed that for multisensory integration to be an orderly process, it should take place between stimuli at congruent spatial locations. In the monkey posterior parietal cortex, the ventral intraparietal (VIP) area is specialized for the analysis of movement information using visual, somatosensory, vestibular, and auditory signals. Focusing on the visual and tactile modalities, we found that in area VIP, like in the superior colliculus, multisensory signals interact at the single neuron level, suggesting that this area participates in multisensory integration. Curiously, VIP does not use a single, invariant coordinate system to encode locations within and across sensory modalities. Visual stimuli can be encoded with respect to the eye, the head, or halfway between the two reference frames, whereas tactile stimuli seem to be prevalently encoded relative to the body. Hence, while some multisensory neurons in VIP could encode spatially congruent tactile and visual stimuli independently of current posture, in other neurons this would not be the case. Future work will need to evaluate the implications of these observations for theories of optimal multisensory integration.Edited by: Marie-Hélène Giard and Mark Wallace 相似文献
Close links exist between the processing of numbers and the processing of space: relatively small numbers are preferentially associated with a left-sided response while relatively large numbers are associated with a right-sided response (the SNARC effect). Previous work demonstrated that the SNARC effect is triggered in an automatic manner and is highly flexible. Besides the left-right dimension, numbers associate with other spatial response mappings such as close/far responses, where small numbers are associated with a close response and large numbers with a far response. In two experiments we investigate the nature of this association. Associations between magnitude and close/far responses were observed using a magnitude-irrelevant task (Experiment 1: automaticity) and using a variable referent task (Experiment 2: flexibility). While drawing a strong parallel between both response mappings, the present results are also informative with regard to the question about what type of processing mechanism underlies both the SNARC effect and the association between numerical magnitude and close/far response locations. 相似文献