Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ 1-42 oligomer injection

Soluble oligomeric forms of amyloid beta (AβO) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer’s disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of AβO (10 μM) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50 mg/kg/day, 5 days, p.o.) improved AβO-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented AβO-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD.     

Demanding kin relations and depressive symptoms among low-income African American women: mediating effects of self-esteem and optimism

Association of demanding kin relations, depressive symptoms, self-esteem, and optimism was assessed among 130 low-income African American women. Demanding relations with kin were positively associated with depressive symptoms and negatively linked to self-esteem and optimism. Self-esteem and optimism were negatively associated with depressive symptoms and mediated the association of demanding relations with kin and women's depressive symptoms. Findings were discussed in terms of the detrimental effects of demanding social relations with kin and the possible role that other relationships may play in compensating for poor relations with extended family.     

Differential priming effect for subliminal fear and disgust facial expressions

Compared to neutral or happy stimuli, subliminal fear stimuli are known to be well processed through the automatic pathway. We tried to examine whether fear stimuli could be processed more strongly than other negative emotional stimuli using a modified subliminal affective priming paradigm. Twenty-six healthy subjects participated in two separated sessions. Fear, disgust and neutral facial expressions were adopted as primes, and 50% happy facial stimuli were adopted as a target to let only stronger negative primes reveal a priming effect. Participants were asked to appraise the affect of target faces in the affect appraisal session and to appraise the genuineness of target faces in the genuineness appraisal session. The genuineness instruction was developed to help participants be sensitive to potential threats. In the affect appraisal, participants judged 50% happy target faces significantly more 'unpleasant' when they were primed by fear faces than primed by 50% happy control faces. In the genuineness appraisal, participants judged targets significantly more 'not genuine' when they were primed by fear and disgust faces than primed by controls. These findings suggest that there may be differential priming effects between subliminal fear and disgust expressions, which could be modulated by a sensitive context of potential threat.     

Culture-specific patterns in the prediction of life satisfaction: roles of emotion, relationship quality, and self-esteem

This study was conducted to explore the culture-specific roles of emotion, relationship quality, and self-esteem in determining life satisfaction. It was hypothesized that maintaining good interpersonal relationships would make individuals in collectivistic cultures not only feel good about their lives but also feel better about themselves. Furthermore, two emotion variables--emotional expression and emotion differentiation--were proposed as possible determinants of relationship quality. It was hypothesized that emotional expressiveness would be more important for maintaining good interpersonal relationships in individualistic societies but emotion differentiation would be more important in collectivistic cultures. These hypotheses were tested with Euro-American, Asian American, Korean, and Chinese groups using multigroup analyses in a structural equation model. Results supported all proposed hypotheses and indicated that emotion differentiation contributes to maintaining good interpersonal relationships in collectivistic cultures, which contributes to self-esteem and satisfaction with life.     

Young children are more likely to cheat after overhearing that a classmate is smart

Research on moral socialization has largely focused on the role of direct communication and has almost completely ignored a potentially rich source of social influence: evaluative comments that children overhear. We examined for the first time whether overheard comments can shape children's moral behavior. Three‐ and 5‐year‐old children (N = 200) participated in a guessing game in which they were instructed not to cheat by peeking. We randomly assigned children to a condition in which they overheard an experimenter tell another adult that a classmate who was no longer present is smart, or to a control condition in which the overheard conversation consisted of non‐social information. We found that 5‐year‐olds, but not 3‐year‐olds, cheated significantly more often if they overheard the classmate praised for being smart. These findings show that the effects of ability praise can spread far beyond the intended recipient to influence the behavior of children who are mere observers, and they suggest that overheard evaluative comments can be an important force in shaping moral development.     

Managing job seekers' organizational image beliefs: the role of media richness and media credibility

In this article, the authors assessed job seekers' organizational image beliefs before and after they experienced 3 recruitment media. The authors examined whether perceptions of media richness and credibility were related to improvements in the correspondence between job seekers' image beliefs and firms' projected images. Both media richness and credibility perceptions were associated with correspondence between job seekers' image beliefs and firms' projected images. However, results revealed that richness and credibility perceptions were likely to enhance job seekers' initial beliefs about firms' images when their beliefs were positive but did not diminish job seekers' beliefs about firms' images when their initial impressions were too positive.     

Neuropsychological findings of extrapontine myelinolysis without central pontine myelinolysis

Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to the rapid correction of hyponatremia, which are reported to show brain stem signs and various movement disorders. Cognitive dysfunction and neuropsychological findings, however, have seldom been reported. Cognitive manifestations in osmotic myelinolysis may have been underestimated due to the prominent brain stem symptoms and movement disorders. We report a case of EPM without CPM and describe the neuropsychological findings of EPM. The absence of CPM in this case made it possible to test neuropsychological function in the acute stage. Neuropsychological testing showed severe impairment of attention, verbal and visual memory, visuospatial function, and frontal/executive function. Language and language-related functions were normal except naming.     

242例吸毒女性自尊及背景资料的调查与分析

运用自尊量表和背景资料调查问卷对甘肃省两大戒毒所242例吸毒女性进行测查,结果表明：（1）年龄、婚姻状况、文化程度、经济收入水平等因素与吸毒女性自尊评分无显著相关;（2）回归分析显示,人际关系因子对吸毒女性自尊评分有显著影响,认知、行为因子对其自尊评分的影响没有达到显著性水平;（3）文化程度不高,无固定的经济收入,失恋或离婚等因素是吸毒或吸毒成瘾的重要关联因素。     

Social transmission of disinhibition in young children

The present study examined whether young children's behaviors in the Dimensional Change Card Sorting task can be influenced by their observation of another person performing the task. Experiment 1 showed that after children watched an adult sorting cards according to one rule, although the children were instructed to sort the cards according to a new rule, most 3-year-olds made perseverative errors and used the observed, old rule to sort the cards instead of the new rule. However, only some 4-year-olds and few 5-year-olds made the same mistake. Experiments 2, 3 and 4 showed that the younger children took into consideration social pragmatic information displayed by the adult model when deciding to use the old rule or the new rule. When the model appeared to know that she sorted the cards incorrectly (Experiments 2 and 3), or was uncertain whether she sorted cards correctly (Experiment 4), most 3-year-olds no longer committed perseverative errors. When the adult model was confident about her sorting or oblivious to her sorting errors, most 3-year-olds made perseverative errors. These results taken together suggest that social observation can lead to disinhibitions. In other words, disinhibition can be transmitted socially from one person to another.     

Social grooming in the kindergarten: the emergence of flattery behavior

The present study examined the emergence of flattery behavior in young children and factors that might affect whether and how it is displayed. Preschool children between the ages of 3 and 6 years were asked to rate drawings produced by either a present or absent adult stranger (Experiments 1 and 2), child stranger (Experiments 2 and 3), classmate, or the children's own teacher (Experiment 3). Young preschoolers gave consistent ratings to the same drawing by the person regardless of whether the person was absent or present. In contrast, many older preschoolers gave more flattering ratings to the drawing when the person was present than in the person's absence. Also, older preschoolers displayed flattery regardless of whether the recipient was an adult or a child. However, they displayed flattery to a greater extent towards familiar individuals than unfamiliar ones, demonstrating an emerging sensitivity to social contexts in which flattery is used. These findings suggest that preschoolers have already learned not to articulate bluntly their true feelings and thoughts about others. Rather, they are able to manipulate their communications according to social context.