Young adults with severe congenital hypothyroidism: cognitive event related potentials (ERPs) and the significance of an early start of thyroxine treatment

Congenital hypothyroidism (CH) has devastating effects upon brain development if left untreated. Despite early start of thyroxine treatment, patients still show subtle cognitive deficits compared to controls. We aimed to study auditory event related potentials (ERPs) in young CH adults (N = 12) to verify previous reports of normal attention functions measured by P3 in CH children. We also include ERP components (P1, N1, P2) allowing assessment of a wider range of auditory processing functions. No significant change in P3 latency or amplitude was found in the CH group, but a more subtle change in amplitude topography. A later start of thyroxine treatment was related to increased P3 latency and reduced amplitude. Group differences were found in early ERP components tapping sensory processing, sensory gating and selective attention. The results suggest persisting abnormalities in auditory processing and selective attention that may have influenced cognitive development.     

Families and therapists achieve clinical outcomes,systems of care mediate the process

Conclusion The values articulated in the system of care philosophy (Stroul & Friedman, 1994) have been necessary elements of local, state, and national efforts to reform mental health care for children. The importance of the values of family collaboration, cultural competence, interagency coordination, individualized care, and use of the least restrictive treatment setting articulated by the system of care philosophy has been affirmed by practitioners, policy makers, and mental health services researchers. Such values, however, are likely not sufficient to achieve clinical outcome. Clinical outcomes are more likely to be achieved by family members and therapists when clinical practices are changed to reflect the demanding and comprehensive work of changing child and family social ecologies.     

The effect of question type on resistance to misinformation about present and absent details

The typical misinformation effect shows that accuracy is lower for details about which people received misleading compared to non-misleading (control) information. In two experiments, we examined the misinformation effect for non-witnessed details (i.e., absent). Three question types introduced control, misleading, and absent details (closed, closed-detailed, and open questions) about a mock burglary video. On this misinformation test, participants' reports of absent details were less accurate than control details only when they were introduced using open questions. Misinformation effects in a subsequent recognition test were present for misleading details in both experiments, but for absent details only in Experiment 2. Experiment 2 also revealed that participants who avoided answering open questions containing misleading and absent details had more accurate memories for these details on the subsequent recognition test than participants who answered these questions. In both experiments, confidence was lowest for absent details. Implications for theory and practice are discussed.     

Becoming happier takes both a will and a proper way: an experimental longitudinal intervention to boost well-being

An 8-month-long experimental study examined the immediate and longer term effects of regularly practicing two assigned positive activities (expressing optimism and gratitude) on well-being. More important, this intervention allowed us to explore the impact of two metafactors that are likely to influence the success of any positive activity: whether one self-selects into the study knowing that it is about increasing happiness and whether one invests effort into the activity over time. Our results indicate that initial self-selection makes a difference, but only in the two positive activity conditions, not the control, and that continued effort also makes a difference, but, again, only in the treatment conditions. We conclude that happiness interventions are more than just placebos, but that they are most successful when participants know about, endorse, and commit to the intervention.     

The cognitive and hedonic costs of dwelling on achievement-related negative experiences: implications for enduring happiness and unhappiness

Increasing evidence suggests that multiple cognitive and motivational processes underlie individual differences in happiness (Lyubomirsky, 2001, 2008). One behavior that is associated with (un)happiness is self-reflection or dwelling. We hypothesized that unhappy individuals would be inclined to dwell about themselves, and that this behavior would have a variety of adverse consequences. Three studies tested the prediction that, unlike their happier peers, unhappy participants would be sensitive to unfavorable achievement feedback, likely to dwell about its implications and, hence, show impaired attention during important academic tasks. The results of Studies 1 and 2 showed that unhappy participants who had "failed" relative to peers subsequently displayed increased interfering thoughts; spent the most time performing a portion of the graduate record examination; and later demonstrated impaired reading comprehension. Study 3 experimentally induced versus inhibiting dwelling and found that the manipulation only impacted unhappy students. Implications of our results for the consequences of dwelling for work and social functioning, as well as for detracting from enduring happiness, are discussed.     

Beyond the right hemisphere: brain mechanisms mediating vocal emotional processing

Vocal perception is particularly important for understanding a speaker's emotional state and intentions because, unlike facial perception, it is relatively independent of speaker distance and viewing conditions. The idea, derived from brain lesion studies, that vocal emotional comprehension is a special domain of the right hemisphere has failed to receive consistent support from neuroimaging. This conflict can be reconciled if vocal emotional comprehension is viewed as a multi-step process with individual neural representations. This view reveals a processing chain that proceeds from the ventral auditory pathway to brain structures implicated in cognition and emotion. Thus, vocal emotional comprehension appears to be mediated by bilateral mechanisms anchored within sensory, cognitive and emotional processing systems.     

What’s Human Rights Got to Do with It? On the Proposed Changes to SSHRC Ethics Research Policy

What’s human rights got to do with it? That is, what’s human rights got to do with the June 2004 report of the Social Sciences and Humanities Research Ethics Special Working Committee to the Inter-Agency Advisory Panel on Research Ethics. The disturbing answer is “not enough.” Certain key recommendations of the working committee, it is suggested, would unacceptably weaken the researcher’s legal and moral accountability to research participants. Those particular recommendations rely on misguided references to academic freedom and the nature of the non-medical research context. In fact, universal human rights, and the legal instruments in which they are embodied ought to inform the research endeavor at every stage; from problem selection to analysis and conclusions. This will lead us closer to shared truths rather than simply to the academic elite’s vision of truth. Without sufficient regard for the human rights of research participants academic freedom itself is not possible.     

A cell-permeable phospholipase Cgamma1-binding peptide transduces neurons and impairs long-term spatial memory

Growth factor-mediated signaling has emerged as an essential component of memory formation. In this study, we used a phospholipase C gamma 1 (PLCgamma1) binding, cell-penetrating peptide to sequester PLCgamma1 away from its target, the phosphotyrosine residues within the activated growth factor receptor. Peptides appear to transduce neurons but not astrocytes or oligodendrocytes. The presence of the peptides in the hippocampus during training in the Morris water maze significantly impaired long-term memory, but not memory acquisition. These results, along with previous studies on extracellular signal-regulated kinase (ERK) and phosphoinositide-3 kinase (PI3K), implicate all three key growth factor receptor-activated intracellular signaling pathways in memory storage.     

“From natural function to indeterminate content”

In his recent bookExplaining Behavior, Fred Dretske has outlined a naturalized theory of intentionality. Several philosophers, including Dretske himself, view his theory as lending credence to the claim that mental state content should be construed widely. In this paper I argue that careful analysis of his theory reveals that this view is mistaken. In Dretske's theory, the notion of the function of a state plays a central role in the determination of content. It will be my contention that this notion of function cannot be used in Dretske's theory to distinguish between the wide construal of the content of an intentional state and the narrow or individualistic construal. This inability of his notion of function to discriminate between wide content and individualistic content undermines any claim that Dretske's theory endorses wide content. Instead, we are lead to the conclusion that Dretske's theory entails pervasive content indeterminacy.