Some problems of Wilson's disease

The Leipzig Center for Wilson's Disease in the GDR is charged with the registration and diagnosis of all homozygous Wilson gene carriers, the clarification of all suspected cases, including the heterozygote test, and the co-ordination of long-term treatment. At present, there are 78 recorded Wilson gene carriers living. On the basis of our own comprehensive observations and investigations over prolonged periods of time, questions concerning pathogenesis, genetics, diagnosis and therapeutic measures, including their side-effects, are dealt with.     

A new Visual Aesthetic Sensitivity Test (VAST): II. cross-cultural comparison between England and Japan

A comparison was made of the scores of 171 Japanese boys and 156 Japanese girls, and of 204 English boys and 165 English girls, on the Visual Aesthetic Sensitivity Test. Also compared were 145 male and 163 female Japanese students, with 38 male and 73 female English students. Japanese children had scores significantly higher than English children, while Japanese students had scores significantly lower than English students. There was little evidence of age increments in score for either group of children. Difficulty levels of the 42 item-pairs were very similar in the two cultures, as were internal (split-half) reliabilities. It is concluded that cultural differences between the two countries, as far as visual aesthetic appreciation is concerned, seem at best minimal.     

Facial myokomias in brain stem tumors]

Four cases of brain-stem tumor were described, in which myokymias were electromyographically derived from the region of several cerebral nerves. An attempt is made to interpret the effects of twitching by reference to the electromyogram. Myokymias are a positive indication of organic brain stem damage. The use subtle techniques of electromyographic examination shows that this muscular hyperkinesis is not so infrequent a symptom as is generally believed.     

Problems and prospects in group psychotherapy research

The scientific basis of psychotherapeutic findings involves a number of difficulties which are above all connected with the insufficient state of basic research in this field. In this situation, significant advances can only be expected on the basis of a systematic long-term investigation and research programme. This applies in particular to the problems of personality and efficiency diagnostics and to group process research. On the basis of some intermediate results, it is shown that by the combined and systematic use of procedures a number of possibilities for the differentiated recording of the complex processes in therapeutic groups can be obtained.     

Time errors and differential sensation weighting

Sixteen pairs of successive tones, with different amplitude combinations, were presented with 16 combinations of tone duration and interstimulus interval. A separate group of 12 subjects was assigned to each presentation condition and made comparative loudness judgments for each of the pairs. Perceived within-pair loudness differences were scaled by a Thurstonian method using the subjective width of the "equal" category as the unit. The scale differences were well described by weighted linear combinations of the sensation magnitudes of the tones in the pairs. The time error can be regarded as an effect of this differential weighting. For the longer interstimulus intervals, the weight of the second tone was the greater, causing the usual inverse relation between time error and stimulus intensity level. For the shorter interstimulus intervals, these effects were reversed. An analysis of the pattern of weights led to the development of two models, one of which is a generalization of Michels and Helson's time error model. The weights could be interpreted as reflecting the differential efficiency of the loudness information from the two compared stimuli.     

Conflict play and its modification in the course of treating children

The authors report their experience with a special form of psychodrama for the treatment in small groups of neurotic children aged five to fifteen. The acting out of ambivalent, partly unconscious and restrained tendencies and inclinations by playing, i.e., by taking roles in spontaneous performances, is followed by alternation of identification in the group and, possibly, careful indirect verbalization by the therapeutist and/or group, of which the purpose is to arrive at a reorientation of the attitudes of patients and a consolidation of the newly won attitude.     

Cardiac autonomic reactivity and recovery in predicting carotid atherosclerosis: the cardiovascular risk in young Finns study.

The present study examined the association of cardiac autonomic task-induced reactivity and recovery to preclinical atherosclerosis. Thirty-three men and 33 women aged 24-39 years participated in the ongoing epidemiological Cardiovascular Risk in Young Finns study. The authors measured heart rate (HR), respiratory sinus arrhythmia (RSA), and preejection period (PEP) during the mental arithmetic and speech tasks in 1999. Carotid atherosclerosis was assessed by measuring the thickness of the common carotid artery intima-media complex (IMT) with ultrasound in 2001. Higher HR, RSA, and PEP reactivity were associated with lower IMT values even after adjusting for cardiovascular risk factors (lipid levels, obesity, and blood pressure). In addition, better HR recovery after the mental arithmetic task was associated with lower IMT values, and this association persisted after all adjustments. Thus, higher task-induced cardiac autonomic reactivity and better HR recovery were related to less preclinical atherosclerosis. The authors concluded that cardiac pattern of reactivity and quick recovery may be associated with better cardiovascular health, and therefore all reactivity occurring in challenging situations should not automatically be considered as potentially pathological.