Relationship between chronic stress and carotid intima-media thickness (IMT) in elderly Alzheimer's disease caregivers

The stress associated with providing care for a spouse diagnosed with Alzheimer's disease can have adverse effects on cardiovascular health. One potential explanation is that chronic caregiving stress may contribute to the development of atherosclerosis. The purpose of this study was to determine whether the duration that one has provided care is associated with the degree of atherosclerotic burden, as measured by carotid artery intima-media thickness (IMT). One hundred and ten Alzheimer caregivers [mean age 74?±?8 (SD) years, 69% female] underwent in-home assessment of carotid artery IMT via B-mode ultrasonography. Data regarding medical history, blood pressure, and multiple indicators of caregiving stress were also collected. Multiple regression indicated that duration of care was positively associated with IMT measured in the internal/bifurcation segments of the carotid artery (β?=?0.202, p?=?0.044) independent of risk factors such as age, gender, body mass index, smoking history, sleep quality, hypertension status, and caregiving stressors. Duration of care was positively associated with IMT in the common carotid artery, but the relationship was not significant. These findings provide more evidence of the link between chronic caregiving stress and cardiovascular disease and indicate that enduring the experience of caregiving over a period of years might be associated with atherosclerotic burden.     

Psychometric properties of the Spanish version of the Thougth-Shape Fusion Questionnaire

The objectives of the study were to analyze the psychometric properties, factor structure and internal consistency of the Spanish version of the Thought-Shape Fusion Questionnaire (TSF-Q), as well as to determine its validity by evaluating the relationship of the TSF-Q to different instruments. Two groups were studied: one comprising 146 patients with a diagnosis of anorexia (n = 82), bulimia (n = 33) or unspecified eating disorder (n = 31), and another group of 115 undergraduates with no history of psychological disorder. All participants completed the TSF-Q, TAF-Q, EDI-2, STAI, BDI and SCL-90-R. Differences in TSF-Q scores between the diagnostic subgroups were also analyzed. Two factors were obtained which coincided with the two sections indicated by the authors of the questionnaire: conceptual and interpretative. The internal consistency of the TSF-Q and its subscales was determined by means of Cronbach's alpha, with values ranging between .93 and .96. The correlations with other instruments reflected adequate validity. There were no significant differences between the diagnostic subgroups. The Spanish version of the TSF-Q meets the psychometric requirements for measuring thought-shape fusion and shows adequate internal consistency and validity.     

Development and validation of the theory of planned behavior questionnaire in physical activity

The Theory of Planned Behavior (TPB) is one of the main theoretical models in the study of the different variables, which influence in the practise of physical activity. The aim in this study was to develop a questionnaire based on TPB in physical activity context providing evidence for the validity of the obtained measures. The instrumental project included three independent studies. The first study entailed the construction and qualitative assessment of the items. In the second study, the analysis of factorial structure was performed by means of exploratory measures, and it showed that the reliability of measures was adequate. The third study provided evidence on the dimensionality of the scale. The confirmatory factorial analysis guaranteed the stability of factorial structure proposed by the TPB and provided evidence for the internal validity of the inventory. Moreover, this study provided evidence of its external validity.     

What Exactly Is It All About? Puzzled Comments from a French Legal Scholar on the NBIC Convergence

The techno-scientific development has no frontier, but the legal systems still take roots in local and cultural references. French Law is built on a continental model and conveys values and preferences of the French population, including an essential role given to the State and to textual requirements. Until now, French law has been modified to cope with new and emerging technologies issues with the idea that they can be taken one after the other, on the fringes of the classic legal problems. Do the announcement of a convergence between Nanotechnologies, Biotechnologies, the sciences of Information and Cognition (NBIC) change the situation? According to “converging technologies” partisans, a lot of other deep perturbations may occur. Therefore, it could be pertinent to assess the legal implications of NBIC convergence. But trying to do so, a French legal scholar may first feel (and express) perplexity. What is the “convergence NBIC”? To answer, do we have to wonder which reality hides behind the expression or is it necessary to admit that the speeches are here more important to analyze than a hypothetical realization? Does it imply new legal questions? Do we need new methods to enlighten what is at stake? Is it a new challenge, stimulating the imagination of lawyers and legal scholars, or, on the contrary, is it a new illustration of the Economy of the promises, revealing big risks of vain (or inappropriate) intellectual and normative production? This article is dedicated to enlighten the important difficulties which mark out the road towards the answers to the legal questions raised by the “NBIC convergence”.     

Psychophysics in the field: Perception and memory for labor pain

Separate groups of women estimated the painfulness of labor contractions either immediately (perceptual judgments) or at time intervals varying from 8 to 48 h after their completion (memorial judgments). The pain judgments of individual uterine contractions were related functionally to the biometrically measured magnitude of these contractions. Perceived and remembered painful sensations were related to referent intensities by power functions governed, as a rule, by exponents greater than unity. Exponents for the memory functions were consistently greater than those for the perceptual functions. Psychophysics done in the field can help decide theoretical issues in addition to providing useful practical information.     

Simulating the variability of actual outcomes

A method is described for simulating the variability of outcomes encountered in a variety of settings. Outcome values falling within a specified range are randomly generated and presented across subjects and trials, so that, over time, the average values seen by all subjects in a condition are the same. Randomly varying reinforcement dimensions (such as magnitude) over trials for each subject is recommended to enhance both the internal and the external validity of laboratory results. In addition, it can be used to study the effects of the variability or uncertainty of outcome dimensions such as magnitude and duration in investigations of behaviors such as matching, melioration, and behavioral momentum.     

Relations between approaches to studying and note-taking behaviour in lectures

Copies of notes taken during a lecture were obtained from first-year psychology students, and the relations examined between measures derived from these (the number of points recorded, the number of words written, and the number of words per point) and a number of variables measuring personality and approach to studying. Three variables were found to be related to the measures derived from the notes: older students, those scoring high on strategic learning (strategy component) and those scoring high on surface learning (motivational component), both measured by questions derived from Biggs (1979), produced longer notes and recorded more of the important points in the lecture. The results suggest that relations between approaches to studying and specific study behaviour are not straightforward and require more detailed investigation.     

Construction of monadic three-valued Łukasiewicz algebras

The notion of monadic three-valued ukasiewicz algebras was introduced by L. Monteiro ([12], [14]) as a generalization of monadic Boolean algebras. A. Monteiro ([9], [10]) and later L. Monteiro and L. Gonzalez Coppola [17] obtained a method for the construction of a three-valued ukasiewicz algebra from a monadic Boolea algebra. In this note we give the construction of a monadic three-valued ukasiewicz algebra from a Boolean algebra B where we have defined two quantification operations and ^* such that ^*x=^*x (where ^*x=-^*-x). In this case we shall say that and ^* commutes. If B is finite and is an existential quantifier over B, we shall show how to obtain all the existential quantifiers ^* which commute with .Taking into account R. Mayet [3] we also construct a monadic three-valued ukasiewicz algebra from a monadic Boolean algebra B and a monadic ideal I of B. The most essential results of the present paper will be submitted to the XXXIX Annual Meeting of the Unión Matemática Argentina (October 1989, Rosario, Argentina).     

The GABAergic effect of low doses of lorazepam on social behavior

The aim of this work was to test the antiaggressive effects of lorazepam and to determine whether these effects were mediated by benzodiazepine receptors. In a first experiment, male mice were injected with lorazepam in a range of low doses (0.05, 0.1, 0.2, and 0.6 mg/kg) or saline solution. In a second experiment, 1 mg/kg of Ro 15‐1788, a benzodiazepine receptor antagonist, and a saline solution were injected before the behavioral test. Results showed that 0.6 mg/kg of lorazepam was the only dose that decreased the total duration of threat (P < .01) and social investigation (P < .05) and that 1 mg/kg of Ro 15‐1788 had no effects. In the third experiment, animals received two injections: 0.6 mg/kg of lorazepam plus 1 mg/kg of Ro 15‐1788, 0.6 mg/kg of lorazepam plus saline solution, or saline solution plus saline solution. Those treated with lorazepam and saline solution spent less time digging (P < .001), threatening (P < .001), and attacking (P < .05) and more time avoiding the opponent (P < .01) or being immobile (P < .001) than the controls. Ro 15‐1788 was successful in completely antagonizing the behavior modulated by lorazepam. Aggr. Behav. 28:248–256, 2002. © 2002 Wiley‐Liss, Inc.