Individual,family, and societal dimensions of genetic discrimination: A case study analysis

Background. As the development and use of genetic tests have increased, so have concerns regarding the uses of genetic information. Genetic discrimination, the differential treatment of individuals based on real or perceived differences in their genomes, is a recently described form of discrimination. The range and significance of experiences associated with this form of discrimination are not yet well known and are investigated in this study. Methods. Individuals at-risk to develop a genetic condition and parents of children with specific genetic conditions were surveyed by questionnaire for reports of genetic discrimination. A total of 27,790 questionnaires were sent out by mail. Of 917 responses received, 206 were followed up with telephone interviews. The responses were analyzed regarding circumstances of the alleged discrimination, the institutions involved, issues relating to the redress of grievances, and strategies to avoid discrimination. Results. A number of institutions were reported to have engaged in genetic discrimination including health and life insurance companies, health care providers, blood banks, adoption agencies, the military, and schools. The alleged instances of discrimination were against individuals who were asymptomatic and sometimes impacted on other asymptomatic relatives. Few surveyed respondents knew of the existence of institutions such as state insurance commissions or the Medical Information Bureau, Inc., which may play roles in redress of grievances or correction of misinformation. Conclusions. Genetic discrimination is variable in form and cause and can have marked consequences for individuals experiencing discrimination and their relatives. The presence of abnormal genes in all individuals makes each person a potential victim of this type of discrimination. The increasing development and utilization of genetic tests will likely result in increased genetic discrimination in the absence of contravening measures. All authors contributed equally to this work. This work was supported by a grant from the U.S. Department of Energy and funding from the Department of Mental Retardation of the Commonwealth of Massachusetts.     

A single-subject approach to evaluating vehicle safety belt reminders: Back to basics

A single-subject ABA reversal design was applied to evaluate the effectiveness of a limited 8-s safety belt reminder system and two modified reminder systems (a delayed and second reminder) to increase the safety belt use of 13 drivers. The research was conducted with a specially equipped research vehicle that permitted the manipulation of different safety belt reminder stimuli and the unobtrusive recording of a driver's belt use. For 2 subjects, the limited 8-s reminder increased safety belt use. For another 2 subjects, the second reminder markedly increased belt use. Some subjects were uninfluenced by the reminder systems presented; others always buckled up during both baseline and intervention conditions. The approach and results are discussed with regard to the application of behavior analysis methodologies (e.g., cumulative records) and principles (e.g., schedules of reinforcement) to advance the utility and investigation of safety belt reminder systems.     

KNOWING WHEN TO SAY WHEN: A SIMPLE ASSESSMENT OF ALCOHOL IMPAIRMENT

The use of writing samples as indices of alcohol impairment was explored. Students at a campus fraternity party wrote a sentence and their signatures before and after consuming alcohol (in beer and mixed drinks). Later, undergraduate and graduate students attempted to discriminate between pre- and postparty handwriting samples. The average percentage of correct discriminations of entrance and exit writing samples was 83.7% for sentences and 67.5% for signatures, and the percentage of correct discriminations increased directly with the blood alcohol concentration of the partier who gave the writing sample. When a partier's blood alcohol concentration reached 0.15, all of the judges accurately discriminated 90% or more of the sentences, and 25 of the 28 judges correctly discriminated at least 80% of the signatures. All of the judges correctly discriminated at least 90% of the 18 sentences written by partiers with a blood alcohol concentration of 0.12 or more. Implications of these findings for reducing the risk of driving while intoxicated are discussed, as well as directions for follow-up research.     

Conditioned suppression in goldfish as a function of shock-reinforcement schedule

The conditioned suppression technique (Estes and Skinner, 1941) was employed to study the effects of partial-shock reinforcement in the goldfish. Lever-pressing behavior of hungry goldfish was suppressed in the presence of a flashing light that had been previously paired with electric shocks. Fish that acquired the suppression under 50% and 100% shock-reinforcement, respectively, were subjected to repeated presentations of the flashing light alone. This procedure revealed a more rapid extinction of the suppressed behavior in the 50% than in the 100% shocked group. The finding was compared with those from other experiments and possible reasons for the differences were examined.     

Contemporary ethics from an ambiguous past.

Kaveny recommends models drawn from the Gospel of John and the practices of the early church for modern Christians in their response to older women and their health needs. She draws upon a historical reconstruction of the early Christian Order of Widows to propose a normative standard of care for elderly women, one that attends seriously to their bodily needs but also to their needs for inclusion and engagement in the social and vocational world both as givers and recipients of care. This is also to serve as an overarching model for a bioethics that prizes the embodied existence of all women and rejects judgments of appropriate treatment based on their social utility. The following response raises questions about the exegetical and historical foundations of Kaveny's analysis. However, these caveats may not detract substantially from the normative usefulness of her work.     

Emotional-vulnerability and mindfulness: a preliminary test of associations among negative affectivity, anxiety sensitivity, and mindfulness skills

This study evaluated associations between general (negative affectivity) and specific (anxiety sensitivity) factors that may relate to the mindfulness skill domains assessed by the Kentucky Inventory of Mindfulness Skills. Participants were 154 young adults (88 females; M(age) = 22.4 years, SD = 7.9) recruited from the community. Partially consistent with predictions, higher levels of negative affectivity were significantly associated with lower levels of Awareness, Acceptance, and Describe mindfulness skills, and higher levels of anxiety sensitivity were significantly associated with lower levels of Awareness and Acceptance mindfulness skills. Additionally, negative affectivity and anxiety sensitivity each demonstrated unique relations to participants' ability to experience the present state without evaluating or judging its content (Accept factor), after accounting for their shared variance, but only anxiety sensitivity demonstrated a unique association to the Act with Awareness factor independent of variance explained by negative affectivity. Findings are discussed in relation to theory and research on mindfulness processes.