Intracerebroventricular Administration of Mineralocorticoid Receptor Antisense Oligonucleotides Attenuates Salt Appetite in the Rat

The anterior ventral third ventricle (AV3V) region of the brain contains high concentrations of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) that are important in the maintenance of body fluid and electrolyte balance as well as other physiological processes. Daily intracerebroventricular pulse injections of MR antisense oligonucleotides significantly suppressed deoxycorticosterone acetate (DOCA) induced salt appetite in a dose-related manner. Similar administration of GR antisense or scrambled/sense oligonucleotide into the third ventricle failed to inhibit salt appetite. Salt appetite aroused after adrenalectomy was not suppressed by MR antisense oligonucleotide treatments but was suppressed by an antisense oligonucleotide directed against the angiotensin II AT1 receptor subtype. Receptor binding analysis demonstrated that MR and GR oligonucleotide treatments each reduced their respective receptor subtypes. Finally, although GR antisense oligonucleotide treatment was ineffective in suppressing DOCA-induced salt appetite, this treatment did increase stress induced corticosterone release as well as delayed the recovery of corticosterone to basal levels after stress.     

Career Experiences and Scientific Performance: A Study of Social,Physical, Life,and Health Sciences

The experiences people have over the course of their careers are commonly held to contribute to creative achievement. In this study, an attempt was made to identify the career events contributing to creative achievement in the sciences. Prior theoretical and empirical work was used to identify relevant career events in the areas of education, domain exposure, mentoring, adversity, work procedures, collaboration, laboratory leadership, and organizational influences. Obituaries were obtained for 499 scientists working in multiple fields in the social, physical, life, and health sciences and were used to assess whether these events were evident in scientists' careers. Comparisons of high achieving and low achieving scientists with regard to these events indicated that multiple events lying in each of these general areas contributed to career achievement. The nature of the events yielding significant differences were discussed regarding their implications for the development of creative potential in scientific fields.     

Workload history effects: A comparison of sudden increases and decreases on performance

The present study examined workload history effects by manipulating sudden changes in workload level, and was designed to enable a direct comparison between sudden increasing and decreasing in workload conditions. A sample of 149 undergraduates was randomly assigned to either a sudden decrease or a sudden increase in workload condition. Participants performed a Sternberg memory task while percent correct was recorded. Mixed-model ANOVA results indicated that performance was significantly impaired for both conditions. Findings supported previous research suggesting that either a sudden decrease (High to Medium) or increase (Low to Medium) workload could result in impaired performance (Cox-Fuenzalida, in press; Cox-Fuenzalida & Angie, in press; Cox-Fuenzalida, Swickert & Hittner, 2004). Furthermore, this study suggests that a sudden decrease may result in greater detrimental effects. The authors express their gratitude to the research team from the Personality and Human Performance Research Laboratory at the University of Oklahoma for their invaluable assistance in data planning and collection. Laura Sohl is currently employed with the Oklahoma Office of Personnel Management.     

A randomized controlled trial of expressive writing in breast cancer survivors with lymphedema

Objective: Breast cancer survivors who develop lymphedema report poorer quality of life (QoL) than those without lymphedema. Expressive writing is a potential intervention to address QoL.

Design: Adult women (N = 107) with breast cancer and chronic Stage II lymphedema were randomised to writing about thoughts and feelings specific to lymphedema and its treatment (intervention) or about daily activities (control) for four, 20-min sessions.

Main Outcome Measures: Outcome measures were several indicators of QoL assessed at baseline, one, three, and six months post-intervention (total scores and subscales of Upper Limb Lymphedema 27 and Functional Assessment of Cancer Therapy–Breast). Hypothesised moderators of change in QoL were dispositional optimism, avoidant behaviours, and time since lymphedema diagnosis.

Results: There was no statistically significant intent-to-treat main effects of expressive writing on QoL. Statistically significant moderating effects on change in different indicators of QoL were observed for all three moderators. Expressive writing was more effective for improving QoL in women who were higher on optimism, lower on avoidance and had less time since a lymphedema diagnosis.

Conclusion: These results provide further evidence that there are subsets of individuals for whom expressive writing is more effective. Future research may investigate targeting expressive writing based on identified moderators.     

The Impact of Cancer on Psychological and Social Outcomes

Cancer is now the biggest cause of mortality worldwide. Although the debilitating physical symptoms of cancer have long been known, the psychological and social impacts of cancer have become the subject of examination only relatively recently. The psychological outcomes that have been examined are primarily negative emotional variables, e.g., anxiety, but emerging research has focused on positive emotional variables, e.g., post‐traumatic growth, or cognitive outcomes. In this article, we provide a synthesis of reviews that have addressed the psychosocial impact of cancer. The framework for this synthesis is provided by a conceptualisation in which the presence of cancer impacts on psychosocial outcomes either directly or via mediating variables, including physical symptoms and treatment, and that this effect may be moderated by several variables, some characteristic of the person with cancer (demographic or personality‐related variables) and some characteristic of their environment (social support and medical variables). We also briefly examine the impact of cancer on the broader family unit following cancer diagnosis, treatment, survivorship and bereavement. We conclude that the heterogeneity of the cancer experience highlights the need for theoretically driven research and consistency in measurement approaches to determine mechanisms by which cancer exerts influence on psychosocial outcomes. This would allow development and delivery of targeted psychological interventions and a clearer delineation of the roles of the various parties, including clinical psychologists, family members and policymakers.