Renatus renatus: the Cartesian tradition in British neuroscience and the neurophilosophy of John Carew Eccles

J. C. Eccles (1903-1997) had a highly distinguished career in neurophysiology, being awarded the Nobel Prize for Medicine or Physiology in 1963. This paper sets him within the Cartesian tradition of British neurophysiology initiated by Thomas Henry Huxley in the mid-19th century. It shows how the mind-brain problematique of the Cartesian tradition troubled him throughout his career, leading him finally to a solution in terms of quantum microphysics and microphysiology. This position, which has subsequently become fashionable, is discussed and shown (at least in the form Eccles espoused) to provide no solution to the problem posed by Descartes in the early 17th century.     

Sigmund Koch as critical humanist

Just as Sigmund Koch was a good scientist without succumbing to scientism, he was a good humanist without succumbing to the popular distortions trading on the name of humanism. When humanistic psychology was seduced by the touchy-feely encounter group movement, Koch derided its technology of authenticity as shamelessly meretricious. Later, when postmodern humanists of deconstruction and textual analysis began to be heard in psychology, Koch wryly expressed his preference for the old-fashioned kind of humanism. Koch's interests and his conception of the domain of psychology thus transcended scientific and humanistic labels and boundaries. To be good science, human psychological studies have to start with and be guided by openness to all aspects of being human. No less in the present and future than during his lifetime, the implications of Koch's vision of psychological inquiry warrant discerning and disciplined attention.     

The connubial crucible: newlywed years as predictors of marital delight, distress, and divorce

This study showed that couples' newlywed marriages and changes in their union over the first 2 years foreshadow their long-term marital fate after 13 years. Consistent with the enduring dynamics model, differences in the intensity of newlyweds' romance as well as the extent to which they expressed negative feelings toward each other predicted (a) whether or not they were happy 13 years later (among those who stayed married) and (b) how long their marriage lasted prior to separation (for those who divorced). The results provide little support for the idea that emergence of distress (e.g., increasing negativity) early in marriage leads to marital failure but instead show that disillusionment--as reflected in an abatement of love, a decline in overt affection, a lessening of the conviction that one's spouse is responsive, and an increase in ambivalence--distinguishes couples headed for divorce from those who establish a stable marital bond.     

Effects of LY354740, a novel glutamatergic metabotropic agonist, on nonhuman primate hypothalamic-pituitary-adrenal axis and noradrenergic function

The search for novel anxiolytics and antidepressants has focused on compounds with the potential to reduce excessive hypothalamic-pituitary-adrenal (HPA) axis activity. L-glutamate, an excitatory neurotransmitter ubiquitously present within the central nervous system, conceivably plays an important role in activating the neural sites involved in stress modulation. Deactivation of the HPA axis by glutamatergic neurotransmission modulation may represent a novel therapeutic approach. Accordingly, the acute intravenous effects of the novel metabotropic (mGlu2/3) agonist LY354740 were tested on bonnet macaques (Macaca radiata) undergoing acute infusions of yohimbine, a noradrenergic stimulant. Dependent measures were the magnitude of the increase of plasma cortisol and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) customarily elicited by yohimbine. Next, the effects of 6 weeks of chronic oral administration of LY354740 on baseline (postcapture) plasma cortisol and MHPG levels in comparison to the identical measure in untreated controls were assessed. Subjects chronically treated with LY354740 received yohimbine infusions which were compared to yohimbine infusions and saline infusions in non-LY354740-treated subjects. Preliminary evidence supports the view that acute LY354740 infusion resulted in a marked diminution of yohimbine-induced stress response, as manifest by a substantial attenuation of cortisol and MHPG response observed in comparison to the saline-treated yohimbine condition. Chronic oral administration of LY354740 led to postcapture baseline cortisol levels which were markedly reduced (approximately 50 percent) in comparison to untreated control subjects; however, there were no significant parallel differences in MHPG levels. Yohimbine infusions elicited an increase in cortisol and MHPG levels in both LY354740-treated and non-LY354740-treated subjects, in comparison to declines in cortisol values observed following vehicle infusions (group X time interaction; P<.0001). Chronic LY354740-treated subjects failed to achieve cortisol levels comparable in range to those of untreated subjects primarily because of their low baseline cortisol levels. In contrast, despite equivalent baselines, yohimbine-induced MHPG values were increased overall in the chronically treated group compared to the saline and yohimbine-alone groups. Thus, LY354740 markedly reduced the acute corticoid and noradrenergic response elicited by yohimbine infusion. Chronic administration of LY354740 appears to present a safe and effective mechanism to markedly down-modulate the HPA axis while retaining noradrenergic responsivity.     

Health and educational outcomes of children who experienced severe neonatal medical complications.

To determine the long-term developmental and educational outcomes of a sample of low birthweight infants with intraventricular hemorrhage (IVH), the authors conducted developmental assessments and interviews 8 years after the initiation of an early intervention project. At the time of the follow-up, 62% of the children were experiencing some developmental or behavior problems, with visual impairments, cerebral palsy, and attention deficits occurring most frequently. Grade of IVH and the number of days spent in the neonatal intensive care unit were the best predictors of later developmental delays. The sample also scored below average on school achievement; approximately 30% of those in school were eligible for special education services. These findings corroborate results from investigations with similar populations whose birth characteristics put them at risk for subsequent developmental delay.     

Do self-fulfilling prophecies accumulate, dissipate, or remain stable over time?

The authors examined whether self-fulfilling prophecies accumulate, dissipate, or remain stable over time by using data from more than 500 6th- through 12th-grade students in public school math classes. The authors used multiple regression analyses to assess the extent to which teacher perceptions predicted students' final math marks and standardized math-test scores from 6th through 12th grade. Control variables included 5 measures of student motivation and 2 measures of previous achievement. The results were consistent with both the dissipation and stability hypotheses. Implications for understanding the extent to which social perception creates social reality and the role of expectations in social problems are discussed.     

Brain mechanisms in fatal cardiac arrhythmia.

Intravenous injection of histamine to rabbits was used as a prototype in an investigation of the mechanism of sudden death due to anaphylaxis and other causes. The "dive" reflex, bradycardia due to activation of the ophthalmic branch of the fifth cranial nerve, was induced in thirty-seven of the animals while they inhaled a very small amount of cigarette smoke. Associated with the resulting bradycardia were lowered blood pH and increased serum content of lactic acid and potassium and increased peripheral arterial constriction with elevation of diastolic blood pressure. Intravenous injection of 1 ml of histamine in the presence of the dive reflex induced potentially fatal ventricular arrhythmia, but no cardiac disturbance when administered while the dive reflex was inactive, thereby strongly suggesting that sudden death in anaphylaxis may involve an overzealous response to a normally protective neural reflex.     

Do infants possess innate knowledge structures? The con side

The central question of development is how new forms are made, how some structure, or behavior, or competence that was not there before, arises. This essay argues for a mechanistic answer to the question of the origins of new forms. And, in so doing, the essay argues that the so-called ‘innate versus learned’ dichotomy is logically flawed since ‘innate’ has no specifiable and mechanistic meaning. The essay considers first, a clear case of ‘innate’ structure: the origins of fingers and toes in embryology. The real-time mechanisms which create fingers and toes, however, are general, probabilistic, emergent and distributed across several levels of analyses. The idea of ‘innate’– even though certainly applicable – has no substantive content and yields no predictions about the nature of these mechanisms. The essay considers second, a clear case of a ‘learned’ structure: the origins of the shape bias in children’s early noun learning. Again, the developmental mechanisms are general, probabilistic, emergent and distributed across several levels of analyses. Several criticisms of the argument against ‘innate ideas’ are considered and rebutted.     

A remote-controlled device for long-term blood collection from freely moving, socially housed animals

A remote-controlled device was developed for injection of fluids and collection of blood samples from freely moving, socially housed animals via an indwelling catheter. Samples are collected at times chosen by the investigator, and the animal is not aware that sampling is occurring. This technique allows measurement of plasma catecholamines and other substances that fluctuate rapidly, are affected by psychosocial stimuli, and are altered by capture and other stressful activities that often accompany sample collection. Rapid retrieval of samples is facilitated by remote-controlled injection of an anesthetic. The device has been used to collect blood from dominant and subordinate male baboons before and during events such as chases and presentation of food treats. Heart rate and blood pressure were measured via radio telemetry, and behavior was recorded on videotapes. This technique allowed construction of multifaceted physiological profiles of social roles and behaviors.     

Research on the Internet: Validation of a World-Wide Web mediated personality scale

Two studies were performed to assess the validity of a World-Wide Web (WWW) measure of self-monitoring. In Study 1, Usenet Newsgroups likely to be read by high and low self-monitors were identified and a comparison was made of the extent to which contributors engaged in a form of self-presentation (use ofhandles orscreen names) likely to be influenced by self-monitoring tendencies. Handles were used significantly more frequently in thehigh self-monitoring Newsgroups, supporting the distinction made. In Study 2, participants recruited through these sets of Newsgroups completed the WWW-mediated test. Those from the high self-monitoring groups scored significantly higher. Self-reports of self-monitoring behavior also reflected scores on the scale. The results are interpreted as demonstrating the construct validity of the instrument used and the viability of criterion-group-oriented methods in Internet-mediated research.