Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function

Associations between uncoupling protein (UCP) expression and functional changes in myocardial mitochondrial bio-energetics have not been well studied during periods of starvation stress. Our aim was to study the effects of acute starvation, for 24 or 48 h, on combined cardiac mitochondrial function and UCP expression in mice. Isolated heart mitochondria from female mice starved for 48 h compared to that from mice fed revealed a significantly (p < 0.05) decreased adenosine diphosphate-to-oxygen ratio, a significantly increased proton leak and an increased GTP inhibition on palmitic acid-induced state 4 oxygen consumption (p < 0.05). These bio-energetic functional changes were associated with increases in mitochondrial UCP2 and UCP3 protein expression. In conclusion, our findings suggest that increased UCP2 and UCP3 levels may contribute to decreased myocardial mitochondrial bio-energetic function due to starvation.     

Mothers' representations of their relationships with their toddlers: links to adult attachment and observed mothering.

Mothers (N = 125) and their firstborn sons were studied over an 11-month period to examine relations between mothers' representations of their relationships with their children (measured at 15 months by using the Parent Development Interview [PDI]), adult representations of attachment (measured at 12 months by using the Adult Attachment Interview [AAI]), and observed mothering (measured at 15 and 21 months). Results indicate (a) that mothers classified as autonomous on the AAI scored highest on the joy-pleasure/coherence dimension of the PDI and mothers classified as dismissing on the AAI scored highest on the anger dimension of the PDI and (b) that mothers scoring higher on the joy-pleasure/coherence dimension of the PDI engaged in less negative and more positive mothering.     

Altruism Toward a Deviant in City and Small Town

A field experiment using the "Lost Letter Technique" tested the hypothesis that altruism would be higher in small towns than in cities, unless the person needing help was a social deviant. The hypothesis was derived from Milgram's (1970) overload theory, in which city dwellers are expected to become generally indifferent to, and make fewer differentiations between, unimportant others. A total of 216 letters to one of three addressees (control, somewhat deviant, highly deviant) were "lost", one-half in Tulsa, Oklahoma (population: 347,600) and one-half among 51 small, Oklahoma towns (× population: 2,002). Return rates supported the hypothesis. The data also suggest that a greater intolerance in small towns for social deviance might systematically overwhelm their generally higher levels of social responsibility. Implications are drawn regarding the danger of overgeneralizing negative attributions to urban centers.     

Development and preliminary validation of the body satisfaction scale (BSS)

Abstract

This paper describes the development of a simple paper-and-pencil test designed to measure satisfaction/dissatisfaction with 16 body parts. It is based on the body-cathexis scale of Secord and Jourard (1953) but takes only 2–3 minutes to complete. The factorial structure of the scale is described together with the three summative scales (“general,” “head parts” and “body parts” dissatisfaction) which are derived. The internal consistency of the scales was found to be acceptable. Significant positive correlations are also reported with the Body Shape Questionnaire (Cooper et al., 1987). The paper reports data for female comparison groups (college students, nursing students and female volunteers) and for samples of eating disorder patients and overweight subjects. The latter two groups report significantly higher body dissatisfaction than the comparison groups. Finally, it is argued that the scale is useful for work in health related fields and some current applications are briefly described.     

Cognitive processes in psychological adaptation to miscarriage: A preliminary report

Abstract

Twenty-two women who wished to continue their pregnancies were interviewed several months after their first miscarriage. Levels of anxiety and depression showed an extremely high degree of variability. Cognitive processes in the form of a search for meaning, mastery and self-enhancement hypothesised to be important in adaptation to negative events were assessed. Having an explanation for the miscarriage and the experience leading to a general reappraisal of values were associated with lower levels of intrusive thoughts. A belief in a medical cause was linked to lower anxiety. Women believed that neither they themselves nor their doctors could exert much influence over the outcome of future pregnancies. Stronger belief in personal control was associated with higher anxiety levels. There is a need to consider not only the emotional consequences of miscarriage but also the cognitive mediators influencing such responses and although based upon a small sample this study initiates that process.     

Neurological subtle signs and cognitive development: A study in late childhood and adolescence

Introduction and Aim: Neurological subtle signs (NSS) are often observed during the neurological examination of children and tend to disappear with age. Their persistence into late adolescence or young adulthood has been related to psychiatric and neurocognitive disorders. To provide a better understanding of their functional basis, a longitudinal correlational study with neurocognitive measurements was performed.

Method: We conducted multiple regression and correlation analyses of NSS with demographic and cognitive measures on a subset of 341 healthy children (56% males), taking part in a longitudinal dental study. Participants, whose ages ranged between 11–15 years, at first evaluation, undertook yearly, during 5 years, a 6-item NSS exam (producing a total score ranging between 0–18) and a comprehensive battery of neurocognitive tests. Effects of age, gender, IQ, and 7 neurocognitive factors on NSS were analyzed.

Results: Over the years, NSS scores correlated consistently with selective attention (Stroop test), motor speed (finger tapping), and visuomotor speed (pegboard speed).

Discussion: These results suggest that the disappearance of NSS in late childhood and adolescence occurs primarily in parallel with the development of motor and visuomotor functions and secondarily in relation to higher order functions such as selective attention (Stroop) and executive control (B-A Trails difference).     

Infant interest in their mother's face is associated with maternal psychological health

Early experience can alter infants’ interest in faces in their environment. This study investigated the relationship between maternal psychological health, mother–infant bonding, and infant face interest in a community sample. A visual habituation paradigm was used to independently assess 3.5-month old infants’ attention to a photograph of their mother's face and a stranger's face. In this sample of 54 healthy mother–infant pairs, 57% of mothers (N = 31) reported symptoms of at least one of stress response to trauma, anxiety, or depression. Interest in the mother-face, but not stranger-face, was positively associated with the mother's psychological health. In regression analyses, anxiety and depression predicted 9% of the variance in looking to the mother-face. Anxiety was the only significant predictor within the model. No direct associations were found between mother–infant bonding and infants’ face interest. Taken together, these findings indicate that infant's visual engagement with their mother's face varies with maternal symptoms of emotional distress, even within a community sample.