Dopamine transporter gene moderates response to behavioral parent training in children with ADHD: a pilot study

There is great variability in the degree to which children with attention deficit/hyperactivity disorder (ADHD) improve through behavioral treatments. This study investigates the influence of the dopamine transporter gene (SCL6A3/DAT1) on outcome of behavioral parent training (BPT). Study subjects were a subsample (n = 50, for whom DAT1 genotypes were available) of a randomized controlled BPT effectiveness study (N = 94) comparing BPT plus ongoing routine clinical care (RCC) versus RCC alone in referred children (4-12 years old) with ADHD. Treatment outcome was based on parent-reported ADHD symptoms and behavioral problems. Presence of 2 versus no or 1 DAT1 10-repeat allele served as moderator variable. Time × Treatment × Genotype effect was analyzed with repeated-measures analysis of variance, controlling for baseline medication status. Results indicate that DAT1 moderated treatment response (p = .009). In children with no or 1 DAT1 10-repeat allele, superior treatment effects of BPT + RCC compared with RCC alone were present (p = .005), which was not the case in children with 2 DAT1 10-repeat alleles (p = .57). Our findings suggest that genetic differences in DAT1 in children with ADHD influence their susceptibility to a behavioral intervention directed at shaping their environment through their parents. The role of the dopamine system in motivation and learning and in the aberrant sensitivity to reinforcement in children with ADHD may explain this moderating effect, given that the management of contingencies is typically addressed in BPT.     

A network approach for distinguishing ethical issues in research and development

In this paper we report on our experiences with using network analysis to discern and analyse ethical issues in research into, and the development of, a new wastewater treatment technology. Using network analysis, we preliminarily interpreted some of our observations in a Group Decision Room (GDR) session where we invited important stakeholders to think about the risks of this new technology. We show how a network approach is useful for understanding the observations, and suggests some relevant ethical issues. We argue that a network approach is also useful for ethical analysis of issues in other fields of research and development. The abandoning of the overarching rationality assumption, which is central to network approaches, does not have to lead to ethical relativism.     

Some variables in the blue (red) phenomenon

The relation between spontaneous color choices and ratings of the prototypicality, conspicuousness, and pleasantness of colors was studied in a sample of Dutch college students. Pleasantness, not prototypicality or conspicuousness, determined the four most frequent spontaneous choices--red, blue, green, and purple. Subjects considered blue the most pleasant of the 12 colors studied, which suggests a pleasantness explanation for the "blue phenomenon" found in some countries. The predominance of red as a spontaneous choice replicated the results of previous studies in the Netherlands. Red also was rated highest in prototypicality but was not rated higher by red choosers than by choosers of other colors, so that a simple prototypicality explanation was rejected. Further analysis showed that the predominance of red as the spontaneous choice of Dutch subjects can be explained by an interaction between prototypicality and pleasantness: Subjects tended to choose red when they rated it highly on both variables.     

Sequential response bias in randomized response sequences: A computer simulation

In this study sequential bias in randomized response sequences is simulated by computer. The computer model assumes that response bias is composed of two components. The first is a repetition avoidance tendency, which is simulated by a memory search through the seven most recently produced responses, and the second is a repetition tendency for the two most recently produced responses. This repetition tendency is assumed to be related to the better availability of recently produced responses. Both processes together give a reasonable approximation of human subjects' data.The results can be explained by the assumption that subjects try to control perseveration tendencies by using a comparison-based memory search mechanism.     

Impact of responsibility for a misfortune on schadenfreude and sympathy: further evidence

The authors tested the hypothesis that the more individuals are responsible for their own misfortune, the more schadenfreude (i.e., pleasure derived from another's misfortune) and less sympathy the misfortune evokes in others. The results support the hypothesis, thereby providing further evidence for the role responsibility plays in emotional reactions to the misfortunes of others.     

Can repetition avoidance in randomization be explained by randomness concepts?

Summary A randomness concept hypothesis of repetition avoidance in socalled randomization tasks was studied. The alternative hypothesis proposed is the control hypothesis, which claims that repetition avoidance is caused by the attempts of the subjects to avoid perseveration. Three sequential response production tasks (number randomization, tone randomization, and production of a pleasing tone sequence), one randomness-judgement task, and four perseveration measures were presented to the subjects. Repetition avoidance was found in all three production tasks, including the tone productions in the pleasing condition. Correlations of the randomness judgements with repetition avoidance were generally not found. There was only slight evidence of correlations between the perseveration measures and repetition avoidance. The results suggest that randomness concepts do not contribute to repetition avoidance to any great extent. The control hypothesis is proposed to explain the results.     

Theological Implications of Possible Extraterrestrial Life

Bible and tradition remain silent on intelligent extraterrestrial life, and few modern theologians have expressed themselves on this topic. Scientific insight suggests the possibility, even likelihood, of the development of life on extrasolar earthlike planets. It is argued that such life forms would resemble earthly life (biochemistry, genetic system, neuronal processes) and also develop a religious and moral life. As creatures with free will they would be prone to sin and in need of salvation. It is argued that this would not require multiple incarnations, since Jesus is the cosmic Christ.