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291.
Strength of scopolamine-induced amnesia as a function of time between training and testing 总被引:1,自引:0,他引:1
Variations in the strength of scopolamine-induced amnesia as a function of age of the habit were studied in Swiss Webster mice. Animals were trained in an active avoidance task to a criterion of 9/10 avoidances and immediately following training injected with scopolamine hydrochloride (1.0 mg/kg) or saline. Retention of the avoidance learning was evaluated by testing different groups of animals 1, 3, 7, 10, 14, and 28 days following training. The retention test consisted of five trials in which the CS but not the UCS was presented. Results indicated that saline-treated mice exhibited near-perfect retention up to 14 days post-training with forgetting beginning to be apparent at 28 days. Scopolamine treatment produced strong amnesia in animals tested 1 and 3 days post-training but normal retention in animals tested 7 and 10 days after learning. The amnesia abruptly reappeared at 14 days after which time it remained stable. The marked similarity of the scopolamine retention curve to changes in the strength of memory of discrimination learning in undertrained rats reported by Deutsch suggested that scopolamine resulted in the storage of a weak memory of the avoidance response. To explore this idea further we trained mice to a criterion (4/5) which would result in a weak avoidance response and tested different groups 1, 3, 10, 14, and 28 days following learning. Results showed that strength of the memory of avoidance learning increased up to 10 days and then decreased abruptly at 14 days thus replicating the general shape of the retention curve produced by injecting scopolamine following strong training. These data suggest that scopolamine disrupts processes essential for the formation of durable memories. 相似文献
292.
The development of the understanding of affective meaning in music was investigated. Subjects aged 4, 5, 6, and 19 assigned verbal labels to musical segments previously determined by adults to be representative of one of four affects (happy, sad, angry, afraid). Analysis of correct interpretations and errors revealed a pattern of interactions among age, sex, and affect indicating that the ability to verbalize an understanding of affective meaning in music consistent with that of adult subjects is present during the preschool years. Age-related similarities in performance, as well as differences favoring both younger and older subjects, were observed and were discussed in relation to recent research in, and theories of, affective development and communication.The authors thank H. Julia Hannay, Edward Kemery, Shiela MacDonald, and Robert McGrath for their assistance in this research. The conceptual inspiration of Joseph Intrieri is gratefully acknowledged. We also thank Leslie Brody, Robin Hornik, and several anonymous reviewers for their comments on an earlier draft of the paper. Portions of this research were presented at the Southeastern Conference on Human Development, Baltimore, April 1982. 相似文献
293.
294.
A right-handed man suffered a left parieto-occipital cerebral infarction, causing agraphia with Gerstmann's syndrome but without major aphasia, alexia, or apraxia. Oral spelling was superior to written spelling. Experiments were performed involving (1) analysis of errors in writing, (2) tasks of visual imagery, and (3) identifying letters drawn without leaving a visual trace. The results suggest that the agraphia and Gerstmann's syndrome are due to a dissociation of language skills and visuospatial skills caused by a dominant parieto-occipital lesion. 相似文献
295.
296.
Developmental dyslexia and word retrieval deficits 总被引:5,自引:1,他引:4
Developmental dyslexics, selected on the basis of very slow naming rates on the Rapid Automatic Naming Tasks (RAN), were compared to normal readers on oral language, picture categorization, and reading tasks. Findings indicated that the dyslexics' word retrieval deficits were one symptom of a more generalized, however subtle, oral language deficit which involved both receptive and expressive oral language functioning. The dyslexics' word retrieval problem also seemed chiefly related to language processing and not to deficits in semantic memory as there were no significant differences between dyslexics and controls on a nonverbal semantic memory task (picture categorization). In naming and identifying printed words, the dyslexics appeared to rely considerably upon the "indirect" or "assembly-of-phonology" route; they were slower in naming irregularly spelled words compared to regularly spelled words and on a lexical decision task, the dyslexics were slower in making negative decisions for "pseudohomophones" (e.g., "braik") than for other matched nonwords. Results are discussed in terms of the logogen model with some consideration of a developmental model as well. 相似文献
297.
The ability of right-brain-damaged (RBD) subjects to correctly insert a word into a well-formed stimulus sentence was tested. Subjects also performed three evaluative tasks designed to establish their degree of general cognitive impairment. The performance of RBD subjects on these tasks was compared to that of left-brain-damaged (LBD) and non-brain-damaged (NBD) subjects. Although RBD subjects outperformed LBD subjects on the language-related evaluative tasks, the RBD group was significantly more impaired on a subset of the insertion task. This subset included items which required reassignment of the syntactic status of elements in the stimulus sentence in order for the insertion to be carried out. The results of this study permit refinement of the common characterization of RBD individuals as rigid in their interpretation of meaning and indicate right-hemisphere involvement in aspects of the grammar previously thought to be inaccessible to it. 相似文献
298.
A pediatric auditory version of the Stroop procedure was developed and administered to 48 normal children from 3 to 6 years of age. Our purpose was to define the developmental course characterizing interaction between auditory and semantic speech dimensions in young children. The procedure was a reaction time (RT) task that required children to respond as quickly and as accurately as possible to words spoken by a male or a female voice. Children were instructed to ignore what was said and to push the "Mommy" button if Mommy was talking or the "Daddy" button if Daddy was talking. Performance was obtained for words with neutral, congruent, and conflicting semantic content. Preschool children manifested processing dependencies that were similar to those observed in adults on the visual Stroop procedure. Conflict between semantic and auditory dimensions significantly increased RT and congruence between the two dimensions significantly decreased RT relative to the neutral condition. The pattern of results indicated that the meaning of words was processed automatically in the normal children. The magnitude of the Stroop effect reflected developmental change with increasing age. 相似文献
299.
300.
M J Nissen J L Ross D B Willingham T B Mackenzie D L Schacter 《Brain and cognition》1988,8(1):117-134
We studied an individual with multiple personality disorder in whom each of several personalities claimed to have no direct awareness of the others and to be unable to consciously remember the experiences of other personalities. A broad selection of implicit and explicit memory tests was used to determine the extent to which one personality had access to knowledge acquired by another and the circumstances in which that knowledge would be expressed. The implicit assessment of memory was a necessary but not sufficient condition for demonstrating interpersonality access. The degree of compartmentalization of knowledge in this patient depended largely on whether the interpretation of presented information was likely to differ across personalities. 相似文献