Inflammation in white matter: clinical and pathophysiological aspects

While the central nervous system (CNS) is generally thought of as an immunopriviledged site, immune-mediated CNS white matter damage can occur in both the perinatal period and in adults, and can result in severe and persistent neurological deficits. Periventricular leukomalacia (PVL) is an inflammatory white matter disease of premature infants that frequently results in cerebral palsy (CP). Clinical and experimental studies show that both hypoxic/ischemic and innate immune mechanisms contribute to the destruction of immature oligodendroglia and of axons in the deep cerebral white matter in PVL. No data are yet available as to whether there is any genetic predisposition to PVL or to its neurological sequelae. Multiple sclerosis (MS) is an inflammatory white matter disease that often begins in young adulthood, causes multifocal destruction of mature oligodendroglia and of axons, and eventually leads to substantial cumulative neurological disability. Certain genetic polymorphisms contribute to susceptibility to MS, and adaptive immune responses to myelin-associated self antigens, or to exogenous antigens that mimic these self antigens, play a central role in the pathophysiology of this disease.     

A qualitative examination of the relationships that serve a mentoring function for Mexican American older adolescents

This exploratory study was an in-depth examination of Mexican American adolescents' relationships with nonparental adults. Qualitative interviews with 10 Mexican American adolescents revealed 23 nonparental adults who served a mentoring function in their lives. Six of these nonparental adults were also interviewed. Data analyses were conducted using a grounded theory approach so that the relationships were described in participants' words and experiences. The nonparental adults identified by adolescents included siblings, extended family members, older peers, and institutional figures. The support provided took many different forms, from emotional to informational/experiential support, to modeling behavior, for example. Further, adolescents were supported in eight different areas of their lives. Participants also discussed the perceived benefits of these relationships for adolescents. Future research directions and implications for youth programming are discussed.     

Empirical validation of values in action-inventory of strengths (VIA-IS) in Indian context

This study uses self-report measures completed by one hundred and twenty three (123) undergraduate technology students to investigate the validity of Peterson and Seligman’s (2004) classification system of 24 character strengths embodied in six core virtues. Using exploratory factor analyses we found, that an exact convergence of the character strengths was explicitly absent with the six-virtues. In our study, a five-factor solution was more comprehensive and well representing the resultant factor loadings upon analyzing the data which is further compared to a similar empirical study available for analyzing structural dynamics. In this paper, we have discussed the five-factor solution and renamed the dimensions to show a legitimate picture of the classification system, which requires further justification, and in addition, advocates reanalysis and reinterpretation of the originally propounded values in action (VIA) classification as a recommendation for future research.     

Cervical Cancer Survivors: Meaning in Life

This study endeavors to understand the meaning in life of cervical cancer survivors in India using narrative analysis. Cervical Cancer survivor participants were interviewed to obtain a holistic view of their experiences in their own words, which was followed by administration of Thematic Apperception Test. Interview data was analyzed using Narrative Analysis. The narratives indicated that the participants viewed life being predestined and guided by fate. In some cases the realization of immortality resulted in peace and satisfaction. This renewed meaning was strongly mediated by faith in God and increased religiosity which facilitated hope and resilience. Strong support systems further enhanced meaning in their lives. However, underlying factors like fatigue, fear of recurrence of the disease and perceived burden continue to be distressing factors. On the other hand, some participants who experienced a preoccupation with somatic complaints and ambivalent feelings toward God experienced a sense of meaninglessness, lack of purpose and diminished hope. The most frequently used defense mechanisms were sublimation, reaction formation, undoing, displacement and projection.