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321.
Whitney G. Cole Simone V. Gill Beatrix Vereijken Karen E. Adolph 《Infant behavior & development》2014
The stability of a system affects how it will handle a perturbation: The system may compensate for the perturbation or not. This study examined how 14-month-old infants—notoriously unstable walkers—and adults cope with a perturbation to walking. We attached a platform to one of participants’ shoes, forcing them to walk with one elongated leg. At first, the platform shoe caused both age groups to slow down and limp, and caused infants to misstep and fall. But after a few trials, infants altered their gait to compensate for the platform shoe whereas adults did not; infants recovered symmetrical gait whereas adults continued to limp. Apparently, adult walking was stable enough to cope with the perturbation, but infants risked falling if they did not compensate. Compensation depends on the interplay of multiple factors: The availability of a compensatory response, the cost of compensation, and the stability of the system being perturbed. 相似文献
322.
Emiliano Santarnecchi Elisa Tatti Lucia Mencarelli Francesco Neri Davide Momi Giorgio Di Lorenzo Alvaro Pascual-Leone Simone Rossi Alessandro Rossi 《Cognitive, affective & behavioral neuroscience》2018,18(3):495-508
Coping abilities represent the individual set of mental and behavioral strategies adopted when facing stress or traumatic experiences. Coping styles related to avoidance have been linked to a disposition to develop psychiatric disorders such as PTSD, anxiety, and major depression, whereas problem-oriented coping skills have been positively correlated with well-being and high quality of life. Even though coping styles constitute an important determinant of resilience and can impact many aspects of everyday living, no study has investigated their brain functional connectivity underpinnings in humans. Here we analyzed both psychometric scores of coping and resting-state fMRI data from 102 healthy adult participants. Controlling for personality and problem-solving abilities, we identified significant links between the propensity to adopt different coping styles and the functional connectivity profiles of regions belonging to the default mode (DMN) and anterior salience (AS) networks—namely, the anterior cingulate cortex, left frontopolar cortex, and left angular gyrus. Also, a reduced negative correlation between AS and DMN nodes explained variability in one specific coping style, related to avoiding problems while focusing on the emotional component of the stressor at hand, instead of relying on cognitive resources. These results might be integrated with current neurophysiological models of resilience and individual responses to stress, in order to understand the propensity to develop clinical conditions (e.g., PTSD) and predict the outcomes of psychotherapeutic interventions. 相似文献
323.
Sarah M. Nielsen Lenika M. De Simone Olufunmilayo I. Olopade 《Journal of genetic counseling》2018,27(6):1405-1410
Prior to 2013, genetic testing for Ashkenazi Jewish (AJ) individuals primarily consisted of the three-site BRCA1/BRCA2 AJ panel, full sequencing of BRCA1/2, or the Lynch syndrome mismatch repair genes. Multigene panel testing became more widely available in 2013, but limited data are available regarding the impact of multigene panel testing for AJ individuals. Here, we report the frequency of cancer susceptibility gene mutations in a cohort of 427 AJ individuals seen in the Cancer Risk Clinic at The University of Chicago. We found that 29% of affected and 37% of unaffected individuals carried a pathogenic mutation (32% of overall cohort), primarily known familial mutations in BRCA1/2. A minority of mutations were identified in non-BRCA1/2 genes and consisted mainly of AJ founder mutations in CHEK2, APC, and the mismatch repair genes. A panel of AJ founder mutations would have identified the majority (94%) of mutations in clinically actionable genes in both affected and unaffected patients. Based on recent cost-effectiveness studies, offering all AJ individuals a founder mutation panel may be a cost-effective cancer prevention strategy. 相似文献
324.
Bizzi Fabiola Charpentier-Mora Simone Cavanna Donatella Borelli Jessica L. Ensink Karin 《Journal of child and family studies》2022,31(1):114-127
Journal of Child and Family Studies - Beginning with Ensink’s seminal study (2015), the field entered a new era in which we were able to measure mentalizing in school-aged children. The goal... 相似文献
325.
Journal of Happiness Studies - This naturalistic observation study investigated the influence of broad societal events such as the COVID-19 pandemic on public expressions of gratitude.... 相似文献
326.
A verbal protocol technique, adopted for a web usability evaluation, requires that the users are able to perform a double
task: surfing and talking. Nevertheless, when blind users surf by using a screen reader and talk about the way they interact
with the computer, the evaluation is influenced by a structural interference: users are forced to think aloud and listen to
the screen reader at the same time. The aim of this study is to build up a verbal protocol technique for samples of visual
impaired users in order to overcome the limits of concurrent and retrospective protocols. The technique we improved, called
partial concurrent thinking aloud (PCTA), integrates a modified set of concurrent verbalization and retrospective analysis.
One group of 6 blind users and another group of 6 sighted users evaluated the usability of a website using PCTA. By estimating
the number of necessary users by the means of an asymptotic test, it was found out that the two groups had an equivalent ability
of identifying usability problems, both over 80%. The result suggests that PCTA, while respecting the properties of classic
verbal protocols, also allows to overcome the structural interference and the limits of concurrent and retrospective protocols
when used with screen reader users. In this way, PCTA reduces the efficiency difference of usability evaluation between blind
and sighted users. 相似文献
327.
328.
Some researchers have argued that children's earliest symbols are based on their sensorimotor experience and that arbitrary symbol-referent mapping poses a challenge for them. If so, exposure to iconic symbols (such as one-finger-for-one-object manual gestures) might help children in a difficult domain such as number. We assessed 44 preschoolers’ processing of number gestures and number words on two tasks: give-a-number and how-many. Children were generally more accurate when mapping number words than number gestures onto a number of toys, suggesting that the iconicity of number gestures does not help children map symbols to numbers. We argue that children learn number gestures as arbitrary symbols and do not take advantage of their iconicity. 相似文献
329.
A new look at sensory attenuation. Action-effect anticipation affects sensitivity, not response bias
The systematic association of an action that a person performs with its sensory effects is thought to attenuate that person's perception of the effect of the action. However, whether learned sensorimotor contingencies truly affect perception, rather than just inducing a response bias, has yet to be determined. The experiment presented in this article comprised two parts: an action-effect association phase and a test phase, during which the actions' perceptual effects were tested. During the association phase, specific actions (left-key and right-key presses) were associated with specific visual effects (tilted Gabor patches). In the test phase, participants' left-key presses and right-key presses triggered the onset of a low-contrast tilted Gabor patch in 50% of trials (no stimulus was presented on the remaining 50% of trials). Participants were required to report the presence or absence of this tilted Gabor patch. Our results showed that participants' sensitivity (d') to the Gabor patches was reduced by 10% when the patches were triggered by the action they had previously been associated with. This finding indicates that a person's action does not induce a response bias (c), but changes the perception (d') of the learned action effect. 相似文献
330.
Stephanie Spengler Marcel Brass Simone Kühn Simone Schütz-Bosbach 《Consciousness and cognition》2010,19(1):98-106
Ideomotor theory of human action control proposes that activation of a motor representation can occur either through internally-intended or externally-perceived actions. Critically, sometimes these alternatives of eliciting a motor response may be conflicting, for example, when intending one action and perceiving another, necessitating the recruitment of enhanced action-control to avoid motor mimicry. Based on previous neuroimaging evidence, suggesting that reduced mimicry is associated with self-related processing, we aimed to experimentally enhance these action-control mechanisms during motor contagion by inducing self-focus. In two within-subjects experiments, participants had to enforce their action intention against an external motor contagion tendency under heightened and normal self-focus. During high self-focus participants showed reduced motor mimicry, induced either by mirror self-observation or self-referential judgments. This indicates that a self-focus provoking situation can enhance online action-control mechanisms, needed to resist unintentional motor contagion tendencies and thereby enables a modulation of automatic mirroring responses. 相似文献