Synthetic Biology and the Translational Imperative

Science and Engineering Ethics - Advances at the interface between the biological sciences and engineering are giving rise to emerging research fields such as synthetic biology. Harnessing the...     

Initial perceptions in negotiations: evaluation and response to ‘logrolling’ offers

In negotiations, where several issues are under consideration and parties have different priorities among these issues, integrative agreements can be reached through ‘logrolling’: concessions on low priority issues in exchange for gains on higher priority issues. The present research focuses on the potential role of initial offers in the development of integrative agreements. We show first, that in a simulated competitive market the specific composition of initial offers influences the final agreements, beyond the effect predicted by their overall value. In order to obtain some insight into the judgmental processes that might play a role, we explore the way in which inexperienced negotiators presented with a hypothetical negotiation context evaluate and respond to logrolling versus distributive initial offers. Three hypotheses were tested: logrolling offers convey an implicit message of cooperation, logrolling offers promote understanding of the mutual interest structure of the task, and, finally, logrolling offers establish within‐issue anchors. Results do not support the first two hypotheses: logrolling offers were not necessarily judged more attractive than distributive ones, and they did not seem to affect the deeply rooted fixed‐pie assumption. However, initial offers did establish within‐issue anchors: counter‐offers were affected by the specific composition of the initial offers beyond the effect of their overall value. This anchoring process resulted in logrolling offers yielding a higher profit for their initiator, as well as higher combined profits for both parties. Copyright © 2002 John Wiley & Sons, Ltd.     

A Simon effect with stationary moving stimuli

To clarify whether motion information per se has a separable influence on action control, the authors investigated whether irrelevant direction of motion of stimuli whose overall position was constant over time would affect manual left-right responses (i.e., reveal a motion-based Simon effect). In Experiments 1 and 2, significant Simon effects were obtained for sine-wave gratings moving in a stationary Gaussian window. In Experiment 3, a direction-based Simon effect with random-dot patterns was replicated, except that the perceived direction of motion was based on the displacement of single elements. Experiments 4 and 5 studied motion-based Simon effects to point-light figures that walked in place--displays requiring high-level analysis of global shape and local motion. Motion-based Simon effects occurred when the displays could be interpreted as an upright human walker, showing that a high-level representation of motion direction mediated the effects. Thus, the present study establishes links between high-level motion perception and action.     

Representation of grammatical properties of Italian verbs in the mental lexicon

The present study focuses on the representation of verbs in the Italian mental lexicon and investigates some grammatical properties: inflectional class, mood, tense, and person. Two experiments based on free recall of single inflected forms are reported. The patterns of recall and error are taken as evidence for the grammatical and morphological information exploited in the access to the verb forms. The pattern of results provides support for the hypothesis that in the mental lexicon the information about conjugation and mood is an organizational criterion for the representation of verbal forms. An interaction between mood and conjugation, likely to arise from the difference in productivity between conjugations, is also observed.     

Time course of melody recognition: a gating paradigm study

Recognizing a well-known melody (e.g., one's national anthem) is not an all-or-none process. Instead, recognition develops progressively while the melody unfolds over time. To examine which factors govern the time course of this recognition process, the gating paradigm, initially designed to study auditory word recognition, was adapted to music. Musicians and nonmusicians were presented with segments of increasing duration of familiar and unfamiliar melodies (i.e., the first note, then the first two notes, then the first three notes, and so forth). Recognition was assessed after each segment either by requiring participants to provide a familiarity judgment (Experiment 1) or by asking them to sing the melody that they thought had been presented (Experiment 2). In general, the more familiar the melody, the fewer the notes required for recognition. Musicians judged music's familiarity within fewer notes than did nonmusicians, whereas the reverse situation (i.e., musicians were slower than nonmusicians) occurred when a sung response was requested. However, both musicians and nonmusicians appeared to segment melodies into the same perceptual units (i.e., motives) in order to access the correct representation in memory. These results are interpreted in light of the cohort model (Marslen-Wilson, 1987), as applied to the music domain.     

You Name It: Interpersonal Affect Labeling Diminishes Distress in Romantic Couples

Although it is increasingly acknowledged that social interactions may provide support at times of adversity, whether or how such interactions can buffer distress remains unclear. The objective of the present study was to examine whether naming the emotions of our partner in aversive situations can effectively reduce distress and whether the regulator’s empathy contributes to its effectiveness. We utilized a novel performance-based interpersonal affect labeling (IAL) paradigm. Seventy-four romantic couples were randomly divided into targets and regulators. The targets watched aversive pictures with low and high intensity and rated their level of distress after: (1) simply viewing the picture (control trials) (2) choosing a label that describes their emotional reaction (self-labeling trials), (3) viewing a label chosen for them by the regulator, their partner (IAL trials). It was found that IAL significantly reduced distress compared to self-labeling. Moreover, the effectiveness of IAL increased as a function of the regulator’s level of empathy. The results highlight the importance of empathy in social support and suggest that as simple an action as naming our partner’s emotions may be effective in reducing their distress. Moreover, it emphasizes the potential contribution of nonprofessional help in emotion regulation.     

Expansion of Sidman's theory: The inclusion of prompt stimuli in equivalence classes

Stimulus equivalence is defined as the ability to relate stimuli in novel ways after training in which not all of the stimuli had been directly linked to one another. Sidman (2000) suggested all elements of conditional discrimination training contingencies that result in equivalence potentially become class members. Research has demonstrated the inclusion of samples, comparisons, responses, and reinforcers in equivalence classes. Given the evidence that all elements of a conditional discrimination become part of the class, the purpose of this study was to determine if class-specific prompts would also enter into their relevant equivalence classes. Experiment 1 investigated the inclusion of prompts in an equivalence class using abstract stimuli with neurotypical students enrolled in higher education courses. Experiment 2 systematically replicated Experiment 1 using meaningful stimuli and individuals diagnosed with autism spectrum disorder. The results of both experiments demonstrated that class-specific prompts became part of equivalence classes with the other positive elements of the contingency. The results are discussed in terms of class expansion and the potential impact on equivalence-based instruction.     

Psychological Treatments for Symptoms of Posttraumatic Stress Disorder in Children,Adolescents, and Young Adults: A Meta-Analysis

Meta-analyses of the treatment of posttraumatic stress disorder (PTSD) in childhood and adolescence are restricted to specific trauma, selected interventions, and methodologically rigorous studies. This large meta-analysis quantifies the effects of psychological treatments for PTSD symptoms in children and adolescents. An extensive literature search yielded a total of 13,040 articles; 135 studies with 150 treatment conditions (N = 9562 participants) met the inclusion criteria (psychological interventions with children and/or adolescents with PTSD symptoms that report quantitative measures of symptom change). The mean effect sizes (ESs) for PTSD symptoms ranged from large to small, depending on the control condition. Cognitive behavioral therapy (CBT) yielded the highest ESs. Age and caretaker involvement were identified as moderators. CBT, especially when conducted in individual treatment with the inclusion of parents, is a highly effective treatment for trauma symptoms. Psychological treatments need to be modified to address younger patients’ specific needs.