Defining Nano,Nanotechnology and Nanomedicine: Why Should It Matter?

Nanotechnology, which involves manipulation of matter on a ‘nano’ scale, is considered to be a key enabling technology. Medical applications of nanotechnology (commonly known as nanomedicine) are expected to significantly improve disease diagnostic and therapeutic modalities and subsequently reduce health care costs. However, there is no consensus on the definition of nanotechnology or nanomedicine, and this stems from the underlying debate on defining ‘nano’. This paper aims to present the diversity in the definition of nanomedicine and its impact on the translation of basic science research in nanotechnology into clinical applications. We present the insights obtained from exploratory qualitative interviews with 46 stakeholders involved in translational nanomedicine from Europe and North America. The definition of nanomedicine has implications for many aspects of translational research including: fund allocation, patents, drug regulatory review processes and approvals, ethical review processes, clinical trials and public acceptance. Given the interdisciplinary nature of the field and common interest in developing effective clinical applications, it is important to have honest and transparent communication about nanomedicine, its benefits and potential harm. A clear and consistent definition of nanomedicine would significantly facilitate trust among various stakeholders including the general public while minimizing the risk of miscommunication and undue fear of nanotechnology and nanomedicine.     

That’s not my place: The interacting effects of faultlines,subgroup size,and social competence on social loafing behaviour in work groups

Taking a social relations approach to team diversity, we propose that faultlines—hypothetical dividing lines that split a team into relatively homogeneous subgroups—impact the team members’ propensity to exhibit social loafing behaviour. We further propose that this individual-level reaction to the faultline structure of the team can differ among team members, depending on the size of their subgroup and on their individual social competence. We tested the assumptions with a sample of real teams working on an intellective task during which social loafing behaviour was video-coded. In partial support of the hypotheses, generalized mixed models revealed that social loafing behaviour was most common for team members who were part of a team with strong faultlines, who belonged to the larger subgroup in their team, and who exhibited low levels of social competence. The results therefore highlight the benefits of taking a multilevel approach to the effects of faultlines.     

Career counseling meets motivational interviewing: A sequential analysis of dynamic counselor–client interactions

Motivational Interviewing (MI) is a client-centered communication style with the aim to resolve client ambivalence within a change-related counseling. Its potential benefit for career counseling has been discussed by several scholars but no empirical research has investigated MI in this context so far. The current study used process measures from MI to investigate dynamic interactions within a career counseling intervention. Overall, we analyzed two videotaped sessions of 14 unique counselor–client dyads. Verbal behavior of counselors and clients were coded with two observational coding schemes from MI (one for counselors and one for clients, respectively). Behavior profiles of counselors were compared with benchmarks of good MI. Furthermore, client verbal ambivalence was compared between sessions. Finally, we conducted lag sequential analyses to analyze temporal dynamics between counselor behavior and immediate client verbal responses across N = 6883 behavioral events. Our results showed, first, behavior profiles of career counselors did significantly differ from recommended counseling benchmarks of good MI practice. Second, as assumed on the basis of past studies, client ambivalence decreased across sessions. Third, MI consistent counselor behaviors showed a positive sequential association with client positive career talk, whereas MI inconsistent counselor behaviors showed the reverse pattern. Our results suggest that counseling behaviors recommended from MI are facilitating career interventions. We discuss how trainings in MI could amend career counseling interventions and provide ethical implications when integrating MI into career counseling programs.     

The Career Development of Adolescent Mothers: A Review of 25 Years of Professional Literature

Twenty‐one articles from peer‐reviewed journals published over 25 years (1983–2008) were selected for inclusion in a review of the professional literature on adolescent mothers' career development. Findings identified that the selected literature included a variety of research methods and theoretical approaches, identified areas of need for this population, and discussed impediments to the career development of adolescent mothers. The most frequent recommendations, aside from the need for further research, were to develop and implement comprehensive programs for adolescent mothers that are strength based and responsive to their needs, and to foster career development skills/knowledge and resiliency.     

With the past behind and the future ahead: Back-to-front representation of past and future sentences

Several studies support the psychological reality of a mental timeline that runs from the left to the right and may strongly affect our thinking about time. Ulrich and Maienborn (Cognition 117:126–138, 2010) examined the linguistic relevance of this timeline during the processing of past- and future-related sentences. Their results indicate that the timeline is not activated automatically during sentence comprehension. While no explicit reference of temporal expressions to the left–right axis has been attested (e.g., *the meeting was moved to the left), natural languages refer to the back–front axis in order to encode temporal information (e.g., the meeting was moved forward). Therefore, the present study examines whether a back–frontal timeline becomes automatically activated during the processing of past- and future-related sentences. The results demonstrate a clear effect on reaction time that emerges from a time–space association along the frontal timeline (Experiment 1). However, this activation seems to be nonautomatic (Experiment 2), rendering it unlikely that this frontal timeline is involved in comprehension of the temporal content of sentences.     

Family functioning and socioaffective competencies of children in the beginning of schooling

The aim of this short-term longitudinal study, based on the system theory, was to test the association between different aspects of family functioning of preschoolers and their socioaffective competencies at the end of the first grade. The total sample included 278 children (137 boys and 141 girls) and their families. The analysis of variance results regarding the aspects of family cohesion and harmony showed that preschoolers from more cohesive families display more social skills, while those from more conflicting families display more externalizing behavior problems (aggression and irritability). With respect to the family's ability to resolve problems, it was observed that, especially for middle and upper class families, this aspect is associated with better social skills and fewer internalized behavior problems. Overall, results of the present study suggest that the family functioning at early stage might influence children's abilities to regulate their emotions and to establish/maintain important relationships with peers and teachers in their early school years.     

Space coding for sensorimotor transformations can emerge through unsupervised learning

The posterior parietal cortex (PPC) is fundamental for sensorimotor transformations because it combines multiple sensory inputs and posture signals into different spatial reference frames that drive motor programming. Here, we present a computational model mimicking the sensorimotor transformations occurring in the PPC. A recurrent neural network with one layer of hidden neurons (restricted Boltzmann machine) learned a stochastic generative model of the sensory data without supervision. After the unsupervised learning phase, the activity of the hidden neurons was used to compute a motor program (a population code on a bidimensional map) through a simple linear projection and delta rule learning. The average motor error, calculated as the difference between the expected and the computed output, was less than 3°. Importantly, analyses of the hidden neurons revealed gain-modulated visual receptive fields, thereby showing that space coding for sensorimotor transformations similar to that observed in the PPC can emerge through unsupervised learning. These results suggest that gain modulation is an efficient coding strategy to integrate visual and postural information toward the generation of motor commands.     

Psychological stigma costs as barriers to healthcare use in former soldiers of the German Armed Forces: A qualitative analysis

Individuals decide to use healthcare when the expected benefits outweigh the perceived costs. One of these cost factors in this decision can be stigma. So far, it has not been researched how former soldiers of the German Armed Forces with a service-induced mental illness perceive stigma and how it influences their healthcare use. As stigma is shaped by the socio-cultural context, the setting of the potential healthcare use must be considered. Narrative interviews were conducted with 33 former soldiers with mental health problems. The data were analyzed using a thematic analysis approach, in which codes were formed and emerging themes were systemized. The relationship between stigma and healthcare use was analyzed. Occupational discrimination and social exclusion were experienced in both in the military and civilian context, but stigma functioned differently in each context. In the military context, former soldiers’ self-stigma of mentally ill individuals being weak was in stark contrast to their internalized military standards. This contrast let them avoid disclosure and subsequent healthcare use. In civilian context, the participants perceived 2 different stigma costs: mental illness stigma and former soldier stigma (i.e., stigmatization because of their military past). Both were perceived as barriers to healthcare use. A model, illustrating these different stigma costs in the different contexts, was developed. Further research on the link between stigma and healthcare use of this group is urgently needed.     

The role of attention in processing configural and shape information in 3-D novel objects

Recent research suggests that there is an advantage for processing configural information in scenes and objects. The purpose of this study was to investigate the extent to which attention may account for this configural advantage. In Experiment 1, we found that cueing the location of change in single object displays improved detection performance for both configural and shape changes, yet cueing attention away from the location of change was detrimental only for shape change detection. A configural advantage was present for each cueing condition. Experiments 2A and 2B examined whether the configural advantage persisted in conditions where attention was distributed more widely, using a visual search paradigm. Although searches for configural changes were faster than those for shape changes across all set sizes, both types of information appeared to be processed with similar efficiency. Overall, these results suggest that the configural advantage is independent of the location or distribution of visual attention.