Infant hypotonia, obesity, hypogenitalism and oligophrenia--new viewpoints on the etiology and symptoms of Prader-Willi syndrome

We present four cases of Prader-Willi syndrome. Two of them have an abnormality of a chromosome 15, the other both show different chromosomal abnormalities. Translocations or deletions were found recently in the bands 15q11/12 in about 60% of the cases of Prader-Willi syndrome. The consequences for diagnosis, symptomatology and genetic counselling of the syndrome are discussed.     

Social categorization,visual cues,and social judgements

Recent research on social cognition suggests that lifelike visual and vocal information about a person may strongly mediate the impact of prior social categorical knowledge on social judgements. Other research, however, on the contribution of visual cues to impression formation, suggests that they have relatively little impact. This study sought to resolve these conflicting findings by examining the effect of visual cues on social judgements when subjects possess prior social categorical knowledge varying in salience to the experimental task. Videotaped target interviews were monitored by observers in either sound and vision or sound only, and measures were taken of the targets' perceived personality, their ‘actual’ and ‘predicted’ social performance, and social acceptance by observers. Whilst salience of categorization strongly influenced the quality of judgements, visual cues had little if any effect. However, visual cues strongly influenced subjects' confidence in all three sets of judgements, sound and vision subjects being consistently more confident than their sound only counterparts. The findings are discussed in relation to previous research in both social cognition and visual cues.     

Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 micrograms/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.     

Effects of social isolation in adulthood on odor preferences and urine-marking in male rats

Male rats isolated for 60 days in adulthood spent less time investigating odors of females and urine-marked less over these odors than did males kept in groups of three. Isolated males did not differ from grouped males in their responses to odors of unfamiliar males or their own odors. After social experience the isolated males showed an increase in urine-marking but no change in odor preferences. Individual housing therefore appears to alter olfactory communication in the same way that it does other social behaviors and these changes may be mediated by the same mechanisms.     

Conceptual,methodological, and clinical issues in cognitive-behavioral assessment

This article reviews cognitive-behavioral assessment principles and procedures. The functions of such assessments are noted, and issues and advances in cognitive assessment are discussed. The need for integrated cognitive, behavioral, and affective assessments is then explored. Finally, conceptual methodological, and clinical issues in the integration of assessments and study of reciprocal determinants are presented.Preparation of this paper was supported in part by a General Research Board Faculty Research Award from the University of Maryland. The author would like to thank Steve Graham, Donald Meichenbaum, Barbara Keogh, and Bernice Wong for their feedback during the preparation of this paper.     

When selective adaptation and contrast effects are distinct: a reply to Diehl, Kluender, and Parker

Two alternative conceptualizations of selective adaptation with speech have recently received attention. The adaptation level theory (AL) outlined by Diehl (1981) and a two-stage model outlined by Sawusch and Jusczyk (1981) can both account for much of the adaptation and paired-comparison data. Recently, Diehl, Kluender, and Parker (1985) proposed that all adaptation and contrast data can be accounted for by AL theory. They reported the results of a study that showed evidence of streaming in selective adaptation and claimed that their results provide a counterdemonstration to recent studies that have argued against the AL approach. In the present article, an outline of how the Diehl et al. results can be accounted for by both the two-stage model and AL theory is presented. In addition, a new set of results comparing adaptation and paired-comparison procedures is presented. These results are precisely as predicted by the two-stage model, but they can not be handled by AL theory.     

Treatment of chronic global aphasia with a nonverbal communication system

Four chronic global aphasics were treated with Blissymbols (C. K. Bliss, 1965, Semantography-Blissymbolics, Sydney: Semantography Pub.). As soon as possible the therapeutic communication was based solely on the use of the symbols. Three patients seemed to benefit from therapy. In one case therapy had to be discontinued because of massive perseveration. In one patient expression of needs relied solely on the use of the symbols. In another, expressive speech could be restored to such an extent that communication by the use of symbols was discontinued.