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101.
Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration 总被引:8,自引:0,他引:8
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Self DW Choi KH Simmons D Walker JR Smagula CS 《Learning & memory (Cold Spring Harbor, N.Y.)》2004,11(5):648-657
Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydroxylase levels in the nucleus accumbens (NAc) shell, an effect that could help ameliorate dysphoria and depression associated with withdrawal from chronic cocaine use. Extinction training also increases levels of GluR1 and GluR2/3 AMPA receptor subunits, while normalizing deficits in NR1 NMDA receptor subunits, in a manner consistent with long-term potentiation of excitatory synapses in the NAc shell. Our results suggest that extinction-induced increases in AMPA and NMDA receptors may restore deficits in cortico-accumbal neurotransmission in the NAc shell and facilitate inhibitory control over cocaine-seeking behavior. Other changes identified by gene expression profiling, including up-regulation in the AMPA receptor aggregating protein Narp, suggest that extinction training induces extensive synaptic reorganization. These studies highlight potential benefits for extinction training procedures in the treatment of drug addiction. 相似文献
102.
Craske MG Lang AJ Rowe M DeCola JP Simmons J Mann C Yan-Go F Bystritsky A 《Journal of abnormal psychology》2002,111(1):53-62
This study examined the role of presleep attributions about physiological events during sleep in nocturnal panic attacks. Patients who regularly experienced nocturnal panic were physiologically monitored as audio signals were presented during sleep. They were randomly assigned to 1 of 3 conditions: expected, in which signals of intense physiological changes were expected; unexpected, in which signals of intense physiological changes were not expected; or control, involving distinctly different signals unrelated to physiological responses. The unexpected condition led to substantially more self-reported distress and panic attacks. The experimental conditions did not elicit different autonomic reactions, but those who panicked showed stronger physiological responses than those who did not panic. The findings are consistent with a cognitive model of nocturnal panic attacks. 相似文献
103.
This study was done to explore how perceived scores for leader-member exchange varies among temporary employees and permanent employees. Study of 158 subordinates indicated no significant difference between the two member groups. 相似文献
104.
The purpose of this study was to evaluate the immediate and subsequent effects of fixed-time (FT) food presentations on mouthing. The effects of FT food presentations were analyzed within a three-component multiple schedule in which baseline conditions were implemented during the first and third components and treatment conditions were implemented during the second component. Results indicated that FT food reduced mouthing and that levels of mouthing during post-FT components were reliably lower than pre-FT components. Behavioral mechanisms responsible for treatment effects are discussed. 相似文献
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What are the social psychological processes likely to lead individuals to commit antisocial behaviour? Two experiments are presented showing that students experiencing a publicly degrading situation (a failure on a fictitious test) agreed more often than non-degraded students to participate in a theft to the detriment of a fellow student or even to the detriment of a teacher. We were able to exclude an interpretation in terms of imitation or revenge and suggest that a publicly degrading situation places subjects in a kind of social dependency state which is expressed by a vulnerability to influence. These results are discussed with due regard to the criminological and social psychological literature. 相似文献
107.
Ernest L. Simmons 《Dialog》2007,46(3):189-198
Abstract : The purpose of this article is to provide background overview and contemporary context for the theme of this issue of Dialog, the role of science within theology. Over the last fifty years, this role has primarily involved dialogue and the drive to mutual understanding. That discussion has now reached a new stage seeking to move beyond dialogue toward what some are referring to as hypothetical consonance. One of the most serious constructive proposals moving beyond dialogue is Creative Mutual Interaction (CMI), proposed by Robert John Russell. The first five ways he discusses in CMI specifically address the role of science in theological reflection. It is argued that these five ways will assist the reader in contextualing the discussion found in the articles in this issue. Elaboration of each way is given, concluding with a constructive theological example of the heuristic use of scientific concepts found in quantum field theory. 相似文献
108.
M D Weiler D K Bellinger E K Simmons L K Rappaport D K Urion W J Mitchell N J Bassett P J Burke J Marmor D Waber 《Child neuropsychology》2000,6(1):3-23
The Diagnostic Rating Scale (DRS) was completed by the parents and teachers of 82 children referred for clinical evaluations, 73 referred children seen twice, and 218 non-referred children from the community. The DRS, which uses a categorical rather than a dimensional rating approach, was 70% to 90% sensitive to diagnoses of Attention Deficit/Hyperactivity Disorder (ADHD) made by blind clinical teams. In research and clinical applications, the DRS could improve screening efficiency, especially in situations where it would be desirable to exclude all children who might have ADHD or identify all children with Hyperactive-Impulsive symptoms. Because of its objectivity and consistency with the Diagnostic and Statistical Manual (DSM)-IV criteria, the DRS could facilitate comparison of participant samples across studies. 相似文献
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