Making the case for objective performance metrics in newborn screening by tandem mass spectrometry

The expansion of newborn screening programs to include multiplex testing by tandem mass spectrometry requires understanding and close monitoring of performance metrics. This is not done consistently because of lack of defined targets, and interlaboratory comparison is almost nonexistent. Between July 2004 and April 2006 (N=176,185 cases), the overall performance metrics of the Minnesota program, limited to MS/MS testing, were as follows: detection rate 1:1,816, positive predictive value 37% (54% in 2006 till date), and false positive rate 0.09%. The repeat rate and the proportion of cases with abnormal findings actually been reported are new metrics proposed here as an objective mean to express the overall noise in a program, where noise is defined as the total number of abnormal results obtained using a given set of cut-off values. On the basis of our experience, we propose the following targets as evidence of adequate analytical and postanalytical performance: detection rate 1:3,000 or higher, positive predictive value>20%, and false positive rate<0.3%.     

The latent structure of trait curiosity: evidence for interest and deprivation curiosity dimensions

To evaluate Litman and Jimerson's (2004) Interest/Deprivation (I/D) model of curiosity, 355 students (269 women, 86 men) responded to 6 trait curiosity measures including the Curiosity/Interest in the World scale (C/IW; Peterson & Seligman, 2004), the Curiosity and Exploration Inventory (CEI; Kashdan, Rose, & Fincham, 2004), the Perceptual Curiosity scale (PC; Collins, Litman, & Spielberger, 2004), the Epistemic Curiosity scale (EC; Litman & Spielberger, 2003), and the Curiosity as a Feeling-of-Deprivation scales (CFD; Litman & Jimerson, 2004). Consistent with expectations, the results of confirmatory factor analyses demonstrated that the C/IW, CEI, PC, EC scales defined an Interest (I) curiosity factor, whereas the CFD scales formed a Deprivation (D) curiosity factor. However, as compared to the other interest-based curiosity measures, one of the EC subscales was found to be less differentiated from the CFD scales, presumably because these instruments assess overlapping aspects of Berlyne's (1954) concept of epistemic curiosity. The results of this study indicated that I and D curiosity are related but differentiated curiosity dimensions, providing evidence for the validity of the I/D model.     

How is the therapeutic relationship talked into being?

A review of the place of the therapeutic relationship within systemic approaches to therapy is provided. This serves to contextualize the findings of a research study that subjects therapy sessions to a discursive analysis. The purpose of the analysis is to learn more about the therapeutic relationship through an examination of what actually takes place in sessions. Moments in therapy where therapeutic engagement is stronger and moments when it is weaker are identified and analysed. The discursive contours of a robust therapeutic relationship are highlighted. A theoretical account of the constituents of a stronger therapeutic relationship is constructed from this analysis.

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Corporeal awareness and proprioceptive sense of the phantom

Phantom limb perception almost invariably follows limb amputation, and can be characterized by various corporeal and proprioceptive qualities. We report a study of 283 amputees, which administered a structured questionnaire to systematically determine the relative frequency and nature of various bodily aspects of phantom limb perception. These include the size, shape, posture, and telescoping of the phantom; exteroceptive sensations of itch, touch, pressure, vibration, temperature, and ‘electric’ sensations; and prosthesis embodiment. Phantom limbs were generally found to be characterized by properties that parallel those of the intact body, although with anatomically impossible configurations sometimes being perceived. We suggest that both the internal limb image and limb schemata play a significant role in the continued perception of phantom limbs.     

Two simple approximations to the distributions of quadratic forms

Many test statistics are asymptotically equivalent to quadratic forms of normal variables, which are further equivalent to with z_i being independent and following N(0,1). Two approximations to the distribution of T have been implemented in popular software and are widely used in evaluating various models. It is important to know how accurate these approximations are when compared to each other and to the exact distribution of T. The paper systematically studies the quality of the two approximations and examines the effect of the λ_i and the degrees of freedom d by analysis and Monte Carlo. The results imply that the adjusted distribution for T can be as good as knowing its exact distribution. When the coefficient of variation of the λ_i is small, the rescaled statistic is also adequate for practical model inference. But comparing T_R against will inflate type I errors when substantial differences exist among the λ_i, especially, when d is also large.     

Visual‐motor and executive functions in children born preterm: The Bender Visual Motor Gestalt Test revisited

Böhm, B., Lundequist, A. & Smedler, A.‐C. (2010). Visual‐motor and executive functions in children born preterm: The Bender Visual Motor Gestalt Test revisited. Scandinavian Journal of Psychology, 51, 376–384. Visual‐motor development and executive functions were investigated with the Bender Test at age 5½ years in 175 children born preterm and 125 full‐term controls, within the longitudinal Stockholm Neonatal Project. Assessment also included WPPSI‐R and NEPSY neuropsychological battery for ages 4–7 ( Korkman, 1990 ). Bender protocols were scored according to Brannigan & Decker (2003) , Koppitz (1963) and a complementary neuropsychological scoring system (ABC), aimed at executive functions and developed for this study. Bender results by all three scoring systems were strongly related to overall cognitive level (Performance IQ), in both groups. The preterm group displayed inferior visual‐motor skills compared to controls also when controlling for IQ. The largest group differences were found on the ABC scoring, which shared unique variance with NEPSY tests of executive function. Multiple regression analyses showed that hyperactive behavior and inattention increased the risk for visual‐motor deficits in children born preterm, whereas no added risk was seen among hyperactive term children. Gender differences favoring girls were strongest within the preterm group, presumably reflecting the specific vulnerability of preterm boys. The results indicate that preterm children develop a different neurobehavioral organization from children born at term, and that the Bender test with a neuropsychological scoring is a useful tool in developmental screening around school start.